Long-Term Protective Effect of Serial Infections with H5N8 Highly Pathogenic Avian Influenza Virus in Wild Ducks.


Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
28 09 2022
Historique:
pubmed: 14 9 2022
medline: 1 10 2022
entrez: 13 9 2022
Statut: ppublish

Résumé

Highly pathogenic avian influenza viruses (HPAIVs) of the Goose/Guangdong (Gs/Gd) lineage are an emerging threat to wild birds. In the 2016-2017 H5N8 outbreak, unexplained variability was observed in susceptible species, with some reports of infected birds dying in high numbers and other reports of apparently subclinical infections. This experimental study was devised to test the hypothesis that previous infection with a less-virulent HPAIV (i.e., 2014 H5N8) provides long-term immunity against subsequent infection with a more-virulent HPAIV (i.e., 2016 H5N8). Therefore, two species of wild ducks-the more-susceptible tufted duck (Aythya fuligula) and the more-resistant mallard (Anas platyrhynchos)-were serially inoculated, first with 2014 H5N8 and after 9 months with 2016 H5N8. For both species, a control group of birds was first sham inoculated and after 9 months inoculated with 2016 H5N8. Subsequent infection with the more-virulent 2016 H5N8 caused no clinical signs in tufted ducks that had previously been infected with 2014 H5N8 (

Identifiants

pubmed: 36098512
doi: 10.1128/jvi.01233-22
pmc: PMC9517725
doi:

Substances chimiques

Antibodies, Viral 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0123322

Subventions

Organisme : NIAID NIH HHS
ID : HHSN272201400008C
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93021C00014
Pays : United States

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Auteurs

Valentina Caliendo (V)

Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.

Lonneke Leijten (L)

Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.

Marco W G van de Bildt (MWG)

Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.

Marjolein J Poen (MJ)

Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.

Adinda Kok (A)

Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.

Theo Bestebroer (T)

Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.

Mathilde Richard (M)

Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.

Ron A M Fouchier (RAM)

Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.

Thijs Kuiken (T)

Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.

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Classifications MeSH