Pulse-Echo Quantitative US Biomarkers for Liver Steatosis: Toward Technical Standardization.

Humans Fatty Liver / diagnostic imaging Liver / diagnostic imaging Ultrasonography / methods Biomarkers Reference Standards Non-alcoholic Fatty Liver Disease Magnetic Resonance Imaging

Journal

Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260

Informations de publication

Date de publication:
11 2022
Historique:
pubmed: 14 9 2022
medline: 27 10 2022
entrez: 13 9 2022
Statut: ppublish

Résumé

Excessive liver fat (steatosis) is now the most common cause of chronic liver disease worldwide and is an independent risk factor for cirrhosis and associated complications. Accurate and clinically useful diagnosis, risk stratification, prognostication, and therapy monitoring require accurate and reliable biomarker measurement at acceptable cost. This article describes a joint effort by the American Institute of Ultrasound in Medicine (AIUM) and the RSNA Quantitative Imaging Biomarkers Alliance (QIBA) to develop standards for clinical and technical validation of quantitative biomarkers for liver steatosis. The AIUM Liver Fat Quantification Task Force provides clinical guidance, while the RSNA QIBA Pulse-Echo Quantitative Ultrasound Biomarker Committee develops methods to measure biomarkers and reduce biomarker variability. In this article, the authors present the clinical need for quantitative imaging biomarkers of liver steatosis, review the current state of various imaging modalities, and describe the technical state of the art for three key liver steatosis pulse-echo quantitative US biomarkers: attenuation coefficient, backscatter coefficient, and speed of sound. Lastly, a perspective on current challenges and recommendations for clinical translation for each biomarker is offered.

Identifiants

DOI: 10.1148/radiol.212808 PMID: 36098640 PMC: PMC9613608
pubmed: 36098640
doi: 10.1148/radiol.212808
pmc: PMC9613608
mid: NIHMS1838325
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

265-276

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK119860
Pays : United States

Informations de copyright

© RSNA, 2022.

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Auteurs

David T Fetzer (DT)

From the Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (D.T.F.); Departments of Medical Physics (I.M.R.M., T.J.H.) and Radiology (I.M.R.M.), University of Wisconsin, Institutes for Medical Research, 1111 Highland Ave, Room 1005, Madison, WI 53705; General Electric Healthcare, Milwaukee, Wis (M.W.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.O.); U.S. Food and Drug Administration, Silver Spring, Md (K.A.W.); Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY (J.O.); Department of Natural Sciences, Kettering University, Flint, Mich (T.A.S.); Departments of Biomedical Engineering and Radiology, University of Michigan, Ann Arbor, Mich (J.B.F.); RSNA Quantitative Imaging Biomarkers Alliance (T.J.H.); and Center for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.E.S.).
ORCID: 0000-0002-2420-082X

Ivan M Rosado-Mendez (IM)

From the Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (D.T.F.); Departments of Medical Physics (I.M.R.M., T.J.H.) and Radiology (I.M.R.M.), University of Wisconsin, Institutes for Medical Research, 1111 Highland Ave, Room 1005, Madison, WI 53705; General Electric Healthcare, Milwaukee, Wis (M.W.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.O.); U.S. Food and Drug Administration, Silver Spring, Md (K.A.W.); Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY (J.O.); Department of Natural Sciences, Kettering University, Flint, Mich (T.A.S.); Departments of Biomedical Engineering and Radiology, University of Michigan, Ann Arbor, Mich (J.B.F.); RSNA Quantitative Imaging Biomarkers Alliance (T.J.H.); and Center for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.E.S.).
ORCID: 0000-0003-0778-1260

Michael Wang (M)

From the Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (D.T.F.); Departments of Medical Physics (I.M.R.M., T.J.H.) and Radiology (I.M.R.M.), University of Wisconsin, Institutes for Medical Research, 1111 Highland Ave, Room 1005, Madison, WI 53705; General Electric Healthcare, Milwaukee, Wis (M.W.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.O.); U.S. Food and Drug Administration, Silver Spring, Md (K.A.W.); Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY (J.O.); Department of Natural Sciences, Kettering University, Flint, Mich (T.A.S.); Departments of Biomedical Engineering and Radiology, University of Michigan, Ann Arbor, Mich (J.B.F.); RSNA Quantitative Imaging Biomarkers Alliance (T.J.H.); and Center for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.E.S.).
ORCID: 0000-0002-5784-8550

Michelle L Robbin (ML)

From the Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (D.T.F.); Departments of Medical Physics (I.M.R.M., T.J.H.) and Radiology (I.M.R.M.), University of Wisconsin, Institutes for Medical Research, 1111 Highland Ave, Room 1005, Madison, WI 53705; General Electric Healthcare, Milwaukee, Wis (M.W.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.O.); U.S. Food and Drug Administration, Silver Spring, Md (K.A.W.); Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY (J.O.); Department of Natural Sciences, Kettering University, Flint, Mich (T.A.S.); Departments of Biomedical Engineering and Radiology, University of Michigan, Ann Arbor, Mich (J.B.F.); RSNA Quantitative Imaging Biomarkers Alliance (T.J.H.); and Center for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.E.S.).
ORCID: 0000-0003-4456-5081

Arinc Ozturk (A)

From the Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (D.T.F.); Departments of Medical Physics (I.M.R.M., T.J.H.) and Radiology (I.M.R.M.), University of Wisconsin, Institutes for Medical Research, 1111 Highland Ave, Room 1005, Madison, WI 53705; General Electric Healthcare, Milwaukee, Wis (M.W.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.O.); U.S. Food and Drug Administration, Silver Spring, Md (K.A.W.); Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY (J.O.); Department of Natural Sciences, Kettering University, Flint, Mich (T.A.S.); Departments of Biomedical Engineering and Radiology, University of Michigan, Ann Arbor, Mich (J.B.F.); RSNA Quantitative Imaging Biomarkers Alliance (T.J.H.); and Center for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.E.S.).
ORCID: 0000-0002-5335-3737

Keith A Wear (KA)

From the Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (D.T.F.); Departments of Medical Physics (I.M.R.M., T.J.H.) and Radiology (I.M.R.M.), University of Wisconsin, Institutes for Medical Research, 1111 Highland Ave, Room 1005, Madison, WI 53705; General Electric Healthcare, Milwaukee, Wis (M.W.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.O.); U.S. Food and Drug Administration, Silver Spring, Md (K.A.W.); Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY (J.O.); Department of Natural Sciences, Kettering University, Flint, Mich (T.A.S.); Departments of Biomedical Engineering and Radiology, University of Michigan, Ann Arbor, Mich (J.B.F.); RSNA Quantitative Imaging Biomarkers Alliance (T.J.H.); and Center for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.E.S.).
ORCID: 0000-0003-0318-4821

Juvenal Ormachea (J)

From the Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (D.T.F.); Departments of Medical Physics (I.M.R.M., T.J.H.) and Radiology (I.M.R.M.), University of Wisconsin, Institutes for Medical Research, 1111 Highland Ave, Room 1005, Madison, WI 53705; General Electric Healthcare, Milwaukee, Wis (M.W.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.O.); U.S. Food and Drug Administration, Silver Spring, Md (K.A.W.); Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY (J.O.); Department of Natural Sciences, Kettering University, Flint, Mich (T.A.S.); Departments of Biomedical Engineering and Radiology, University of Michigan, Ann Arbor, Mich (J.B.F.); RSNA Quantitative Imaging Biomarkers Alliance (T.J.H.); and Center for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.E.S.).
ORCID: 0000-0003-2481-8133

Timothy A Stiles (TA)

From the Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (D.T.F.); Departments of Medical Physics (I.M.R.M., T.J.H.) and Radiology (I.M.R.M.), University of Wisconsin, Institutes for Medical Research, 1111 Highland Ave, Room 1005, Madison, WI 53705; General Electric Healthcare, Milwaukee, Wis (M.W.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.O.); U.S. Food and Drug Administration, Silver Spring, Md (K.A.W.); Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY (J.O.); Department of Natural Sciences, Kettering University, Flint, Mich (T.A.S.); Departments of Biomedical Engineering and Radiology, University of Michigan, Ann Arbor, Mich (J.B.F.); RSNA Quantitative Imaging Biomarkers Alliance (T.J.H.); and Center for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.E.S.).
ORCID: 0000-0002-2113-1697

J Brian Fowlkes (JB)

From the Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (D.T.F.); Departments of Medical Physics (I.M.R.M., T.J.H.) and Radiology (I.M.R.M.), University of Wisconsin, Institutes for Medical Research, 1111 Highland Ave, Room 1005, Madison, WI 53705; General Electric Healthcare, Milwaukee, Wis (M.W.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.O.); U.S. Food and Drug Administration, Silver Spring, Md (K.A.W.); Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY (J.O.); Department of Natural Sciences, Kettering University, Flint, Mich (T.A.S.); Departments of Biomedical Engineering and Radiology, University of Michigan, Ann Arbor, Mich (J.B.F.); RSNA Quantitative Imaging Biomarkers Alliance (T.J.H.); and Center for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.E.S.).
ORCID: 0000-0002-4536-3919

Timothy J Hall (TJ)

From the Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (D.T.F.); Departments of Medical Physics (I.M.R.M., T.J.H.) and Radiology (I.M.R.M.), University of Wisconsin, Institutes for Medical Research, 1111 Highland Ave, Room 1005, Madison, WI 53705; General Electric Healthcare, Milwaukee, Wis (M.W.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.O.); U.S. Food and Drug Administration, Silver Spring, Md (K.A.W.); Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY (J.O.); Department of Natural Sciences, Kettering University, Flint, Mich (T.A.S.); Departments of Biomedical Engineering and Radiology, University of Michigan, Ann Arbor, Mich (J.B.F.); RSNA Quantitative Imaging Biomarkers Alliance (T.J.H.); and Center for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.E.S.).
ORCID: 0000-0001-9850-6031

Anthony E Samir (AE)

From the Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (D.T.F.); Departments of Medical Physics (I.M.R.M., T.J.H.) and Radiology (I.M.R.M.), University of Wisconsin, Institutes for Medical Research, 1111 Highland Ave, Room 1005, Madison, WI 53705; General Electric Healthcare, Milwaukee, Wis (M.W.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (M.L.R.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.O.); U.S. Food and Drug Administration, Silver Spring, Md (K.A.W.); Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY (J.O.); Department of Natural Sciences, Kettering University, Flint, Mich (T.A.S.); Departments of Biomedical Engineering and Radiology, University of Michigan, Ann Arbor, Mich (J.B.F.); RSNA Quantitative Imaging Biomarkers Alliance (T.J.H.); and Center for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.E.S.).
ORCID: 0000-0002-7801-8724

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pulse-Echo Quantitative US Biomarkers for...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Pulse-Echo Quantitative US Biomarkers for...
questionsmedicales.fr › Système digestif › Foie › Pulse-Echo Quantitative US Biomarkers for...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Échographie › Pulse-Echo Quantitative US Biomarkers for...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Pulse-Echo Quantitative US Biomarkers for...
questionsmedicales.fr › Techniques d'investigation › Poids et mesures › Normes de référence › Pulse-Echo Quantitative US Biomarkers for...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Stéatose hépatique non alcoolique › Pulse-Echo Quantitative US Biomarkers for...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Pulse-Echo Quantitative US Biomarkers for...