Homologous recombination-deficient mutation cluster in tumor suppressor

Adenosine Triphosphate / metabolism DNA-Binding Proteins / genetics Female Homologous Recombination Humans Mutation Ovarian Neoplasms / genetics Rad51 Recombinase / genetics Tumor Suppressor Proteins / genetics
DNA repair Homologous recombination RAD51 paralog RAD51C Variants of unknown significance

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
20 09 2022
Historique:
entrez: 13 9 2022
pubmed: 14 9 2022
medline: 16 9 2022
Statut: ppublish

Résumé

Mutations in homologous recombination (HR) genes, including

Identifiants

DOI: 10.1073/pnas.2202727119 PMID: 36099300 PMC: PMC9499524
pubmed: 36099300
doi: 10.1073/pnas.2202727119
pmc: PMC9499524
doi:

Substances chimiques

DNA-Binding Proteins 0
RAD51C protein, human 0
Tumor Suppressor Proteins 0
XRCC2 protein, human 0
Adenosine Triphosphate 8L70Q75FXE
Rad51 Recombinase EC 2.7.7.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2202727119

Subventions

Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : F31 CA264889
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA015083
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA241801
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES031796
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES007061
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA253174
Pays : United States

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Auteurs

Rohit Prakash (R)

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.

Yashpal Rawal (Y)

Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
ORCID: 0000-0001-9209-788X

Meghan R Sullivan (MR)

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
ORCID: 0000-0003-4304-0566

McKenzie K Grundy (MK)

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.

Hélène Bret (H)

Institute for Integrative Biology of the Cell, Université Paris-Saclay, CEA, CNRS, Gif-sur-Yvette, 91198 France.
ORCID: 0000-0003-2899-3625

Michael J Mihalevic (MJ)

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.

Hayley L Rein (HL)

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
ORCID: 0000-0001-8939-3442

Jared M Baird (JM)

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
ORCID: 0000-0002-2628-9485

Kristie Darrah (K)

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.

Fang Zhang (F)

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853.
ORCID: 0000-0002-6018-0790

Raymond Wang (R)

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.

Tiffany A Traina (TA)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
ORCID: 0000-0003-3597-0050

Marc R Radke (MR)

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195.

Scott H Kaufmann (SH)

Departments of Oncology and Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905.
ORCID: 0000-0002-4900-7145

Elizabeth M Swisher (EM)

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195.
ORCID: 0000-0003-2331-0434

Raphaël Guérois (R)

Institute for Integrative Biology of the Cell, Université Paris-Saclay, CEA, CNRS, Gif-sur-Yvette, 91198 France.
ORCID: 0000-0001-5294-2858

Mauro Modesti (M)

Cancer Research Center of Marseille, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille Université, Marseille, 13273 France.
ORCID: 0000-0002-4964-331X

Patrick Sung (P)

Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.

Maria Jasin (M)

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
ORCID: 0000-0002-7976-2379

Kara A Bernstein (KA)

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
ORCID: 0000-0003-2247-6459

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Homologous recombination-deficient mutation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Homologous recombination-deficient mutation...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Recombinaison homologue › Homologous recombination-deficient mutation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Homologous recombination-deficient mutation...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Homologous recombination-deficient mutation...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › Homologous recombination-deficient mutation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines des groupes de complémentation de l'anémie de Fanconi › Rad51 Recombinase › Homologous recombination-deficient mutation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Homologous recombination-deficient mutation...