Glutamine energy substrate anaplerosis increases bone density in the Pah

Pahenu2 glutamine osteopenia oxidative phosphorylation phenylketonuria

Journal

JIMD reports
ISSN: 2192-8304
Titre abrégé: JIMD Rep
Pays: United States
ID NLM: 101568557

Informations de publication

Date de publication:
Sep 2022
Historique:
received: 19 04 2022
revised: 25 05 2022
accepted: 30 05 2022
entrez: 14 9 2022
pubmed: 15 9 2022
medline: 15 9 2022
Statut: epublish

Résumé

Osteopenia is an under-investigated clinical presentation of phenylalanine hydroxylase (PAH)-deficient phenylketonuria (PKU). While osteopenia is not fully penetrant in human PKU, the Pah

Identifiants

pubmed: 36101821
doi: 10.1002/jmd2.12308
pii: JMD212308
pmc: PMC9458609
doi:

Types de publication

Journal Article

Langues

eng

Pagination

446-452

Subventions

Organisme : BLRD VA
ID : I01 BX002490
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR076146
Pays : United States

Informations de copyright

© 2022 The Authors. JIMD Reports published by John Wiley & Sons Ltd on behalf of SSIEM.

Déclaration de conflit d'intérêts

No authors have competing interests related to these studies.

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Auteurs

Steven F Dobrowolski (SF)

Department of Pathology University of Pittsburgh, School of Medicine Pittsburgh Pennsylvania USA.

Yu Leng Phua (YL)

Division of Medical Genetics and Genomics Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA.
Present address: Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York USA.

Irina L Tourkova (IL)

Department of Pathology University of Pittsburgh, School of Medicine Pittsburgh Pennsylvania USA.
Pittsburgh Veteran's Affairs Medical Center Pittsburgh Pennsylvania USA.

Cayla Sudano (C)

Department of Pathology University of Pittsburgh, School of Medicine Pittsburgh Pennsylvania USA.

Jerry Vockley (J)

Division of Medical Genetics and Genomics Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA.

Quitterie C Larrouture (QC)

Department of Pathology University of Pittsburgh, School of Medicine Pittsburgh Pennsylvania USA.
Pittsburgh Veteran's Affairs Medical Center Pittsburgh Pennsylvania USA.

Harry C Blair (HC)

Department of Pathology University of Pittsburgh, School of Medicine Pittsburgh Pennsylvania USA.
Pittsburgh Veteran's Affairs Medical Center Pittsburgh Pennsylvania USA.

Classifications MeSH