Association of Implementation of Operating Room-Based Parathyroid Hormone Testing with Operative Time and Cost.


Journal

Journal of the American College of Surgeons
ISSN: 1879-1190
Titre abrégé: J Am Coll Surg
Pays: United States
ID NLM: 9431305

Informations de publication

Date de publication:
01 12 2022
Historique:
pubmed: 15 9 2022
medline: 19 11 2022
entrez: 14 9 2022
Statut: ppublish

Résumé

Intraoperative parathyroid hormone (IOPTH) testing facilitates focused parathyroidectomy to establish biochemical cure but may be time-consuming. A dedicated immunoassay machine was relocated to the operating room for IOPTH. These data seek to determine association of operating room-based IOPTH with operative time, laboratory turnaround time (TAT), and cost. Patients who underwent parathyroidectomy from June 2017 to February 2020 were reviewed. Clinical and demographic data, operative time, and TAT were collected. Patients were compared by operation dates pre- or post-machine acquisition. A cost model was created to evaluate cost of care before and after operating room-based testing. A total of 285 patients were included. Post-machine, median operative time decreased from 69 minutes (interquartile range [IQR] 60 to 84) to 57 minutes (IQR 50 to 84.5), p 0.03. Additionally, median TAT for IOPTH values (preoperative, 0, 5, 10, and 15 minutes) decreased post-machine: time preoperative, 29 minutes (IQR 23 to 40) vs 18 minutes (IQR 17 to 23.5), p < 0.001; time 0, 33 minutes (IQR 27 to 39) vs 18.5 minutes (17.5 to 21), p < 0.001; time 5 minutes, 31 minutes (IQR 26 to 36) vs 20 minutes (IQR 18.5 to 21), p < 0.001; time 10 minutes, 32 minutes (IQR 27 to 39) vs 20 minutes (IQR 18.5 to 22.5), p < 0.001; and time 15 minutes, 30 minutes (IQR 26 to 36) vs 19 minutes (IQR 17 to 21), p < 0.001. Total costs pre- and post-machine were $4,442 and $4,111, respectively. With $331 cost reduction per operation and 127 operations per year, the IOPTH machine pays for itself in 3 years, or 378 surgeries, and saves $168,589 in the machine's remaining 4-year life span. Operating room-based parathyroid hormone testing results in improved operating productivity by decreasing result TAT and operative time and reduces cost.

Sections du résumé

BACKGROUND
Intraoperative parathyroid hormone (IOPTH) testing facilitates focused parathyroidectomy to establish biochemical cure but may be time-consuming. A dedicated immunoassay machine was relocated to the operating room for IOPTH. These data seek to determine association of operating room-based IOPTH with operative time, laboratory turnaround time (TAT), and cost.
METHODS
Patients who underwent parathyroidectomy from June 2017 to February 2020 were reviewed. Clinical and demographic data, operative time, and TAT were collected. Patients were compared by operation dates pre- or post-machine acquisition. A cost model was created to evaluate cost of care before and after operating room-based testing.
RESULTS
A total of 285 patients were included. Post-machine, median operative time decreased from 69 minutes (interquartile range [IQR] 60 to 84) to 57 minutes (IQR 50 to 84.5), p 0.03. Additionally, median TAT for IOPTH values (preoperative, 0, 5, 10, and 15 minutes) decreased post-machine: time preoperative, 29 minutes (IQR 23 to 40) vs 18 minutes (IQR 17 to 23.5), p < 0.001; time 0, 33 minutes (IQR 27 to 39) vs 18.5 minutes (17.5 to 21), p < 0.001; time 5 minutes, 31 minutes (IQR 26 to 36) vs 20 minutes (IQR 18.5 to 21), p < 0.001; time 10 minutes, 32 minutes (IQR 27 to 39) vs 20 minutes (IQR 18.5 to 22.5), p < 0.001; and time 15 minutes, 30 minutes (IQR 26 to 36) vs 19 minutes (IQR 17 to 21), p < 0.001. Total costs pre- and post-machine were $4,442 and $4,111, respectively. With $331 cost reduction per operation and 127 operations per year, the IOPTH machine pays for itself in 3 years, or 378 surgeries, and saves $168,589 in the machine's remaining 4-year life span.
CONCLUSIONS
Operating room-based parathyroid hormone testing results in improved operating productivity by decreasing result TAT and operative time and reduces cost.

Identifiants

pubmed: 36102508
doi: 10.1097/XCS.0000000000000362
pii: 00019464-202212000-00013
doi:

Substances chimiques

Parathyroid Hormone 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

906-912

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.

Références

Lafferty FW. Differential diagnosis of hypercalcemia. J Bone Miner Res. 1991;6(suppl 2):S51–S59; discussion S61.
Mallick R, Chen H. Diagnosis and management of hyperparathyroidism. Adv Surg. 2018;52:137–153.
Jüppner H, Potts JT Jr. Immunoassays for the detection of parathyroid hormone. J Bone Miner Res. 2002;17(suppl 2):N81–N86.
Sokoll LJ, Wians FH Jr, Remaley AT. Rapid intraoperative immunoassay of parathyroid hormone and other hormones: a new paradigm for point-of-care testing. Clin Chem. 2004;50:1126–1135.
Leiker AJ, Yen TW, Eastwood DC, et al. Factors that influence parathyroid hormone half-life: determining if new intraoperative criteria are needed. JAMA Surg. 2013;148:602–606.
Carneiro DM, Solorzano CC, Nader MC, et al. Comparison of intraoperative iPTH assay (QPTH) criteria in guiding parathyroidectomy: which criterion is the most accurate? Surgery. 2003;134:973–979; discussion 979.
Terris DJ, Weinberger PM, Farrag T, et al. Restoring point-of-care testing during parathyroidectomy with a newer parathyroid hormone assay. Otolaryngol Head Neck Surg. 2011;145:557–560.
Cabot JC, Lee CR, Brunaud L, et al. Robotic and endoscopic transaxillary thyroidectomies may be cost prohibitive when compared to standard cervical thyroidectomy: a cost analysis. Surgery. 2012;152:1016–1024.
Link RE, Bhayani SB, Kavoussi LR. A prospective comparison of robotic and laparoscopic pyeloplasty. Ann Surg. 2006;243:486–491.
Anderson GF, Hussey P, Petrosyan V. It’s still the prices, stupid: why the US spends so much on health care, and a tribute to Uwe Reinhardt. Health Aff (Millwood). 2019;38:87–95.
Crawford DA, Lombardi AV Jr, Berend KR. Improving operating room efficiency with single-use disposable instruments for total knee arthroplasty. Surg Technol Int. 2022;40:353–356.
Adamczyk A, Kim P, Beaule P, et al. The SLIM study: economic, energy, and waste savings through lowering of instrumentation mass in total hip arthroplasty. J Arthroplasty. 2022;37(8 suppl):S796–S802.e2.
Leung EKY, Lee CC, Angelos P, et al. Analytical differences in intraoperative parathyroid hormone assays. J Appl Lab Med. 2019;3:788–798.
Zawawi F, Mlynarek AM, Cantor A, et al. Intraoperative parathyroid hormone level in parathyroidectomy: which patients benefit from it? J Otolaryngol Head Neck Surg. 2013;42:56.

Auteurs

Steven Xie (S)

From the Department of Surgery (Xie, Kuriakose, Beninato, Trooskin, Libutti, Laird), Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

Jonathan Kuriakose (J)

From the Department of Surgery (Xie, Kuriakose, Beninato, Trooskin, Libutti, Laird), Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

Toni Beninato (T)

From the Department of Surgery (Xie, Kuriakose, Beninato, Trooskin, Libutti, Laird), Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
the Division of Surgical Oncology, Section of Endocrine Surgery, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ ( Beninato, Trooskin, Libutti, Laird).

Mary Carayannopoulos (M)

Department of Pathology and Laboratory Medicine (Carayannopoulos), Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

Stanley Z Trooskin (SZ)

From the Department of Surgery (Xie, Kuriakose, Beninato, Trooskin, Libutti, Laird), Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
the Division of Surgical Oncology, Section of Endocrine Surgery, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ ( Beninato, Trooskin, Libutti, Laird).

Steven K Libutti (SK)

From the Department of Surgery (Xie, Kuriakose, Beninato, Trooskin, Libutti, Laird), Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
the Division of Surgical Oncology, Section of Endocrine Surgery, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ ( Beninato, Trooskin, Libutti, Laird).

Amanda M Laird (AM)

From the Department of Surgery (Xie, Kuriakose, Beninato, Trooskin, Libutti, Laird), Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
the Division of Surgical Oncology, Section of Endocrine Surgery, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ ( Beninato, Trooskin, Libutti, Laird).

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