Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds.

Animals Anti-Bacterial Agents / pharmacology Biofilms Cattle Humans Keratinocytes Mice Phorbols Wound Healing

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
14 09 2022
Historique:
entrez: 14 9 2022
pubmed: 15 9 2022
medline: 17 9 2022
Statut: ppublish

Résumé

The management of antibiotic-resistant, bacterial biofilm infections in chronic skin wounds is an increasing clinical challenge. Despite advances in diagnosis, many patients do not derive benefit from current anti-infective/antibiotic therapies. Here, we report a novel class of naturally occurring and semisynthetic epoxy-tiglianes, derived from the Queensland blushwood tree (

Identifiants

DOI: 10.1126/scitranslmed.abn3758 PMID: 36103515
pubmed: 36103515
doi: 10.1126/scitranslmed.abn3758
doi:

Substances chimiques

Anti-Bacterial Agents 0
Phorbols 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabn3758

Auteurs

Lydia C Powell (LC)

Advanced Therapies Group, Cardiff University School of Dentistry, Cardiff CF14 4XY, UK.
Centre for Nanohealth, Swansea University Medical School, Swansea University, Swansea SA2 8PP, UK.
ORCID: 0000-0002-8641-0160

Jason K Cullen (JK)

Drug Discovery Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland 4072, Australia.
ORCID: 0000-0003-4961-1673

Glen M Boyle (GM)

Drug Discovery Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland 4072, Australia.
ORCID: 0000-0002-1385-529X

Tom De Ridder (T)

QBiotics Group Limited Yungaburra, Queensland 4884, Australia.
ORCID: 0000-0003-2628-5684

Pei-Yi Yap (PY)

Drug Discovery Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
ORCID: 0000-0002-5824-5591

Wenya Xue (W)

Advanced Therapies Group, Cardiff University School of Dentistry, Cardiff CF14 4XY, UK.
ORCID: 0000-0002-6842-1288

Carly J Pierce (CJ)

Drug Discovery Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.

Manon F Pritchard (MF)

Advanced Therapies Group, Cardiff University School of Dentistry, Cardiff CF14 4XY, UK.
ORCID: 0000-0002-5135-4744

Georgina E Menzies (GE)

School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.
ORCID: 0000-0002-6600-6507

Muthanna Abdulkarim (M)

School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.
ORCID: 0000-0001-5753-7261

Jennifer Y M Adams (JYM)

Advanced Therapies Group, Cardiff University School of Dentistry, Cardiff CF14 4XY, UK.
ORCID: 0000-0002-0339-9032

Joana Stokniene (J)

Advanced Therapies Group, Cardiff University School of Dentistry, Cardiff CF14 4XY, UK.
ORCID: 0000-0002-8836-4209

Lewis W Francis (LW)

Centre for Nanohealth, Swansea University Medical School, Swansea University, Swansea SA2 8PP, UK.

Mark Gumbleton (M)

School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.

Jenny Johns (J)

Drug Discovery Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.

Katja E Hill (KE)

Advanced Therapies Group, Cardiff University School of Dentistry, Cardiff CF14 4XY, UK.
ORCID: 0000-0002-8590-0117

Adam V Jones (AV)

Oral Pathology, Cardiff and Vale University Health Board , Cardiff CF14 4XY, UK.

Peter G Parsons (PG)

Drug Discovery Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
ORCID: 0000-0002-0473-3346

Paul Reddell (P)

QBiotics Group Limited Yungaburra, Queensland 4884, Australia.
ORCID: 0000-0002-0993-8957

David W Thomas (DW)

Advanced Therapies Group, Cardiff University School of Dentistry, Cardiff CF14 4XY, UK.
ORCID: 0000-0001-7319-5820

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Topical, immunomodulatory epoxy-tiglianes...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Topical, immunomodulatory epoxy-tiglianes...
questionsmedicales.fr › Phénomènes microbiologiques › Biofilms › Topical, immunomodulatory epoxy-tiglianes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Topical, immunomodulatory epoxy-tiglianes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Topical, immunomodulatory epoxy-tiglianes...
questionsmedicales.fr › Cellules › Cellules épithéliales › Kératinocytes › Topical, immunomodulatory epoxy-tiglianes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Topical, immunomodulatory epoxy-tiglianes...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Phorbols › Topical, immunomodulatory epoxy-tiglianes...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Cicatrisation de plaie › Topical, immunomodulatory epoxy-tiglianes...