Effects of biological sex mismatch on neural progenitor cell transplantation for spinal cord injury in mice.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
14 09 2022
14 09 2022
Historique:
received:
05
03
2022
accepted:
02
09
2022
entrez:
14
9
2022
pubmed:
15
9
2022
medline:
17
9
2022
Statut:
epublish
Résumé
Despite advancement of neural progenitor cell transplantation to spinal cord injury clinical trials, there remains a lack of understanding of how biological sex of transplanted cells influences outcomes after transplantation. To address this, we transplanted GFP-expressing sex-matched, sex-mismatched, or mixed donor cells into sites of spinal cord injury in adult male and female mice. Biological sex of the donor cells does not influence graft neuron density, glial differentiation, formation of the reactive glial cell border, or graft axon outgrowth. However, male grafts in female hosts feature extensive hypervascularization accompanied by increased vascular diameter and perivascular cell density. We show greater T-cell infiltration within male-to-female grafts than other graft types. Together, these findings indicate a biological sex-specific immune response of female mice to male donor cells. Our work suggests that biological sex should be considered in the design of future clinical trials for cell transplantation in human injury.
Identifiants
pubmed: 36104357
doi: 10.1038/s41467-022-33134-x
pii: 10.1038/s41467-022-33134-x
pmc: PMC9474813
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5380Subventions
Organisme : NINDS NIH HHS
ID : R01 NS116404
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM138098
Pays : United States
Informations de copyright
© 2022. The Author(s).
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