Factors related to cognitive function in type-2 diabetes and neuropathic pain patients, the role of mood and sleep disorders in this relationship.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 09 2022
14 09 2022
Historique:
received:
10
03
2022
accepted:
22
08
2022
entrez:
14
9
2022
pubmed:
15
9
2022
medline:
17
9
2022
Statut:
epublish
Résumé
To compare cognitive function in patients with diabetes mellitus type-2 (T2DM) both with and without diabetic neuropathic pain (DNP). To analyse the relationship between mood and sleep disorders, quality of life and cognitive function in patients with DNP. Cross-sectional study conducted in patients with T2DM and neuropathy. The presence of DNP, cognitive function, mood status, sleep quality, health-related quality of life, pain intensity and phenotype of pain were measured. Descriptive, bivariate and multivariate analyses were performed. A total of 149 patients (71 with DNP) were included. Patients with and without DNP presented similar scores on the TYM (41.46; SD = 6.70 vs. 41.97; SD = 5.50) and those with DNP had a slightly higher frequency of cognitive impairment (TYM score ≤ 41: 40.8% vs. 43.6%). The patients without DNP performed better in the verbal fluency dimension (mean = 3.53; SD = 0.98 vs. mean = 3.82; SD = 0.66). Being older (B = - 0.258) and under treatment with insulin (B = - 2.919) were related with greater cognitive impairment. Obesity (OR = 17.277) and a longer duration of diabetes (OR = 1.317) were also related to greater risk of cognitive impairment. Impaired cognitive function in patients with DNP is more related to T2DM factors than pain factors. The presence of depression and a worse quality of life were related to a greater risk of cognitive impairment. Identifying and controlling these factors should be an essential intervention for maintaining the cognitive function in patients with T2DM and DNP.
Identifiants
pubmed: 36104367
doi: 10.1038/s41598-022-18949-4
pii: 10.1038/s41598-022-18949-4
pmc: PMC9472177
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
15442Informations de copyright
© 2022. The Author(s).
Références
Jongsiriyanyong, S. & Limpawattana, P. Mild cognitive impairment in clinical practice: A review article. Am. J. Alzheimer’s Dis. Demen. 33, 500–507 (2018).
doi: 10.1177/1533317518791401
Vega-Alonso, T. et al. Prevalence of cognitive impairment in Spain: The Gómez de Caso study in health sentinel networks. Neurologia 33, 491–498 (2018).
pubmed: 27939116
Jongsiriyanyong, S. & Limpawattana, P. Mild cognitive impairment in clinical practice: A review article. Am. J. Alzheimer’s Dis. Other Demen. 33, 500–507 (2018).
doi: 10.1177/1533317518791401
van Sloten, T. T., Sedaghat, S., Carnethon, M. R., Launer, L. J. & Stehouwer, C. D. A. Cerebral microvascular complications of type 2 diabetes: Stroke, cognitive dysfunction, and depression. Lancet Diabetes Endocrinol. 8, 325–336 (2020).
pubmed: 32135131
doi: 10.1016/S2213-8587(19)30405-X
Li, W., Sun, L., Li, G. & Xiao, S. Prevalence, influence factors and cognitive characteristics of mild cognitive impairment in type 2 diabetes mellitus. Front. Aging Neurosci. 10, 1–7 (2019).
Whitlock, E. L. et al. Association between persistent pain and memory decline and dementia in a longitudinal cohort of elders. JAMA Intern. Med. 177, 1146–1153 (2017).
pubmed: 28586818
pmcid: 5588896
doi: 10.1001/jamainternmed.2017.1622
Bell, T., Franz, C. E. & Kremen, W. S. Persistence of pain and cognitive impairment in older adults. J. Am. Geriatr. Soc. 70, 1–10. https://doi.org/10.1111/jgs.17542 (2021).
Achterberga, W., Lautenbacherb, S., Huseboc, B., Erdalc, A. & Herr, K. Pain in dementia. Pain 1, e803 (2020).
Shillo, P. et al. Painful and painless diabetic neuropathies: What is the difference?. Curr. Diab. Rep. 19, 32 (2019).
pubmed: 31065863
pmcid: 6505492
doi: 10.1007/s11892-019-1150-5
Rosenberger, D. C., Blechschmidt, V., Timmerman, H., Wolff, A. & Treede, R. D. Challenges of neuropathic pain: Focus on diabetic neuropathy. J. Neural Transm. 127, 589–624 (2020).
pubmed: 32036431
doi: 10.1007/s00702-020-02145-7
Pop-Busui, R. et al. Diabetic neuropathy: A position statement by the American diabetes association. Diabetes Care 40, 136–154 (2017).
pubmed: 27999003
doi: 10.2337/dc16-2042
Sloan, G. et al. A new look at painful diabetic neuropathy. Diabetes Res. Clin. Pract. 144, 177–191 (2018).
pubmed: 30201394
doi: 10.1016/j.diabres.2018.08.020
Elsharkawy, R. E. et al. Peripheral polyneuropathy and cognitive impairment in Type II diabetes mellitus. Neuropsychiatr. Dis. Treat. 17, 627–635 (2021).
pubmed: 33658784
pmcid: 7917357
doi: 10.2147/NDT.S284308
Naranjo, C., Ortega-Jiménez, P., del Reguero, L., Moratalla, G. & Failde, I. Relationship between diabetic neuropathic pain and comorbidity. Their impact on pain intensity, diabetes complications and quality of life in patients with type-2 diabetes mellitus. Diabetes Res. Clin. Pract. 165, 1082 (2020).
doi: 10.1016/j.diabres.2020.108236
Selvarajah, D. et al. Magnetic resonance neuroimaging study of brain structural differences in diabetic peripheral neuropathy. Diabetes Care 37, 1681–1688 (2014).
pubmed: 24658391
doi: 10.2337/dc13-2610
Naranjo, C. et al. Anxiety, depression and sleep disorders in patients with diabetic neuropathic pain: A systematic review. Expert Rev. Neurother. 19, 1201–1209 (2019).
pubmed: 31393191
doi: 10.1080/14737175.2019.1653760
Kioskli, K., Scott, W., Winkley, K., Kylakos, S. & McCracken, L. M. Psychosocial factors in painful diabetic neuropathy: A systematic review of treatment trials and survey studies. Pain Med. (US) 20, 1756–1773 (2019).
doi: 10.1093/pm/pnz071
Bobo, W. V. et al. Association of depression and anxiety with the accumulation of chronic conditions. JAMA Netw. Open 5, e229817 (2022).
pubmed: 35499825
pmcid: 9062691
doi: 10.1001/jamanetworkopen.2022.9817
Haack, M., Simpson, N., Sethna, N., Kaur, S. & Mullington, J. Sleep deficiency and chronic pain: Potential underlying mechanisms and clinical implications. Neuropsychopharmacology 45, 205–216 (2020).
pubmed: 31207606
doi: 10.1038/s41386-019-0439-z
Orgeta, V. et al. Psychological treatments for depression and anxiety in dementia and mild cognitive impairment. Cochrane Datab. Syst. Rev. 2022, 4 (2022).
American Diabetes Association. 2. Classification and diagnosis of diabetes: Standards of medical care in diabetes-2021. Diabetes Care 44, S15–S33 (2021).
Association, A. D. 2. Classification and diagnosis of diabetes. Diabetes Care 39, S13–S22 (2016).
doi: 10.2337/dc16-S005
Zhang, Q. et al. Easier operation and similar power of 10 g monofilament test for screening diabetic peripheral neuropathy. J. Int. Med. Res. 46, 3278–3284 (2018).
pubmed: 29808737
pmcid: 6134636
doi: 10.1177/0300060518775244
Perez, C. et al. Validity and reliability of the Spanish version of the DN4 (Douleur Neuropathique 4 questions) questionnaire for differential diagnosis of pain syndromes associated to a neuropathic or somatic component. Health Qual. Life Outcomes 5, 1–10 (2007).
doi: 10.1186/1477-7525-5-66
Brown, J., Pengas, G., Dawson, K., Brown, L. A. & Clatworthy, P. Self administered cognitive screening test (TYM) for detection of Alzheimer’s disease: Cross sectional study. BMJ 338, 1426–1428 (2009).
doi: 10.1136/bmj.b2030
Brown, J. et al. Test Your Memory (TYM test): Diagnostic evaluation of patients with non-Alzheimer dementias. J. Neurol. 266, 2546–2553 (2019).
pubmed: 31267204
pmcid: 6765477
doi: 10.1007/s00415-019-09447-1
Ojeda, B. et al. Assessing the construct validity and internal reliability of the screening tool test your memory in patients with chronic pain. PLoS ONE 11, 1–16 (2016).
doi: 10.1371/journal.pone.0154240
Ojeda, B., Salazar, A., Dueñas, M. & Failde, I. Traducción y adaptación al castellano del Cuestionario de Detección de Trastorno Cognitivo Leve. Med. Clin. 138, 429–434. https://doi.org/10.1016/j.medcli.2011.08.007 (2012).
doi: 10.1016/j.medcli.2011.08.007
Selvarajah, D. et al. The contributors of emotional distress in painful diabetic neuropathy. Diab. Vasc. Dis. Res. 11, 218–225 (2014).
pubmed: 24821753
doi: 10.1177/1479164114522135
Herrero, M. J. et al. A validation study of the hospital anxiety and depression scale (HADS) in a Spanish population. Gen. Hosp. Psychiatry 25, 277–283 (2003).
pubmed: 12850660
doi: 10.1016/S0163-8343(03)00043-4
Quintana, J. M. et al. Evaluation of the psychometric characteristics of the Spanish version of the Hospital Anxiety and Depression Scale. Acta Psychiatr. Scand. 107, 216–221 (2003).
pubmed: 12580829
doi: 10.1034/j.1600-0447.2003.00062.x
Viala-Danten, M., Martin, S., Guillemin, I. & Hays, R. D. Evaluation of the reliability and validity of the Medical Outcomes Study sleep scale in patients with painful diabetic peripheral neuropathy during an international clinical trial. Health Qual. Life Outcomes 6, 1–12 (2008).
doi: 10.1186/1477-7525-6-113
Schmidt, S. et al. Normas de referencia para el Cuestionario de Salud SF-12 versión 2 basadas en población general de Cataluña. Med. Clin. 139, 613–625 (2012).
doi: 10.1016/j.medcli.2011.10.024
Villoria, J., Rodríguez, M., Berro, M. J., Stern, A. & Sánchez-Magro, I. Psychometric validation of the neuropathic pain symptom inventory for its use in Spanish. J. Pain Symptom. Manag 42, 134–146 (2011).
doi: 10.1016/j.jpainsymman.2010.09.018
Gylfadottir, S. S. et al. Diabetic polyneuropathy and pain, prevalence, and patient characteristics: A cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes. Pain 161, 574–583 (2020).
pubmed: 31693539
doi: 10.1097/j.pain.0000000000001744
Zhang, X., Yang, X., Sun, B. & Zhu, C. Perspectives of glycemic variability in diabetic neuropathy: A comprehensive review. Commun. Biol. 4, 1–9 (2021).
doi: 10.1038/s42003-021-02896-3
Chou, P. H. et al. Reduced frontal activity during a verbal fluency test in fibromyalgia: A near-infrared spectroscopy study. J. Clin. Neurosci. 50, 35–40 (2018).
pubmed: 29426783
doi: 10.1016/j.jocn.2018.01.030
Sharma, G. et al. Cognitive impairments in type 2 diabetes, risk factors and preventive strategies. J. Basic Clin. Physiol. Pharmacol. 31, 1–14 (2020).
doi: 10.1515/jbcpp-2019-0105
Palomo-Osuna, J., de Sola, H., Dueñas, M., Moral-Munoz, J. A. & Failde, I. Cognitive function in diabetic persons with peripheral neuropathy: A systematic review and meta-analysis. Expert Rev. Neurotherapeut. 22, 1–13 (2022).
doi: 10.1080/14737175.2022.2048649
Ojeda, B., Dueñas, M., Salazar, A., Mico, J. & Torres, L. Factors influencing cognitive impairment in neuropathic and musculoskeletal pain and fibromyalgia. Pain Med. 19, 1–12 (2017).
Calatayud, E., Salavera, C. & Gómez-Soria, I. Cognitive differences in the older adults living in the general community: Gender and mental occupational state study. Int. J. Environ. Res. Public Health 18, 1–12 (2021).
doi: 10.3390/ijerph18063106
Moran, C., Beare, R., Wang, W., Callisaya, M. & Srikanth, V. Type 2 diabetes mellitus, brain atrophy, and cognitive decline. Neurology 92, E823–E830 (2019).
pubmed: 30674592
pmcid: 7987953
doi: 10.1212/WNL.0000000000006955
Almigbal, T. H. et al. Association of health literacy and self-management practices and psychological factor among patients with type 2 diabetes mellitus in Saudi Arabia. Saudi Med. J. 40, 1158–1166 (2019).
pubmed: 31707414
pmcid: 6901769
doi: 10.15537/smj.2019.11.24585
RobatSarpooshi, D. et al. The relationship between health literacy level and self-care behaviors in patients with diabetes. Patient Relat. Outcome Meas. 11, 129–135 (2020).
pubmed: 32440244
pmcid: 7211311
doi: 10.2147/PROM.S243678
Mandolesi, L. et al. Effects of physical exercise on cognitive functioning and wellbeing: Biological and psychological benefits. Front. Psychol. 9, 5 (2018).
doi: 10.3389/fpsyg.2018.00509
Bai, A., Tao, L., Huang, J., Tao, J. & Liu, J. Effects of physical activity on cognitive function among patients with diabetes in China: A nationally longitudinal study. BMC Public Health 21, 1 (2021).
doi: 10.1186/s12889-021-10537-x
Iadecola, C. & Gottesman, R. F. Neurovascular and cognitive dysfunction in hypertension: Epidemiology, pathobiology, and treatment. Circ. Res. 124, 1025–1044 (2019).
pubmed: 30920929
pmcid: 6527115
doi: 10.1161/CIRCRESAHA.118.313260
Ruitenberg, A. et al. Blood pressure and risk of dementia: Results from the Rotterdam study and the Gothenburg H-70 study. Dement. Geriatr. Cogn. Disord. 12, 33–39 (2001).
pubmed: 11125239
doi: 10.1159/000051233
den Heijer, T. et al. Association between blood pressure levels over time and brain atrophy in the elderly. Neurobiol. Aging 24, 307–313 (2003).
pubmed: 12498964
doi: 10.1016/S0197-4580(02)00088-X
Buysse-Charles, F., Reynolds-Ill, D. J., Monk, T. H., Berman, S. R. & Kupfer, D. J. The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Res. 28, 193 (1988).
doi: 10.1016/0165-1781(89)90047-4
Burke, S. L. et al. Mild cognitive impairment: Associations with sleep disturbance, apolipoprotein e4, and sleep medications. Sleep Med. 52, 168–176 (2018).
pubmed: 30359892
pmcid: 6800075
doi: 10.1016/j.sleep.2018.09.001