Improving obesity and lipid metabolism using conjugated linoleic acid.
lipid metabolism
nutrition
obesity
Journal
Veterinary medicine and science
ISSN: 2053-1095
Titre abrégé: Vet Med Sci
Pays: England
ID NLM: 101678837
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
pubmed:
16
9
2022
medline:
23
11
2022
entrez:
15
9
2022
Statut:
ppublish
Résumé
Conjugated linoleic acid (CLA) can prevent fatty acid accumulation induced by a high-fructose diet and improve lipid metabolism disorders in patients. We aimed to investigate the effect of CLA on obesity and lipid metabolism and its possible mechanism. Eight-month-old male BKS.Cg-Dock7 CLA treatment notably reduced the dietary and water intake of db/db mice, effectively reduced body weight, and decreased serum TG and TC levels (p < 0.05). Increased expression of PPARα (p < 0.05) and decreased expression of CD36 (p < 0.001) were observed in the liver of mice that were fed CLA. CLA increased PPARα expression (p < 0.001) and decreased PPARγ (p < 0.001) and CD36 expression (p < 0.01) in HepG2 cells. Our results showed that CLA can improve lipid metabolism in obese mice through upregulation of PPARα expression and downregulation of CD36 expression.
Sections du résumé
BACKGROUND
Conjugated linoleic acid (CLA) can prevent fatty acid accumulation induced by a high-fructose diet and improve lipid metabolism disorders in patients.
OBJECTIVES
We aimed to investigate the effect of CLA on obesity and lipid metabolism and its possible mechanism.
METHODS
Eight-month-old male BKS.Cg-Dock7
RESULTS
CLA treatment notably reduced the dietary and water intake of db/db mice, effectively reduced body weight, and decreased serum TG and TC levels (p < 0.05). Increased expression of PPARα (p < 0.05) and decreased expression of CD36 (p < 0.001) were observed in the liver of mice that were fed CLA. CLA increased PPARα expression (p < 0.001) and decreased PPARγ (p < 0.001) and CD36 expression (p < 0.01) in HepG2 cells.
CONCLUSIONS
Our results showed that CLA can improve lipid metabolism in obese mice through upregulation of PPARα expression and downregulation of CD36 expression.
Identifiants
pubmed: 36104831
doi: 10.1002/vms3.921
pmc: PMC9677407
doi:
Substances chimiques
Linoleic Acids, Conjugated
0
PPAR alpha
0
PPAR gamma
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2538-2544Informations de copyright
© 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd.
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