Silk proteins in reconstructive surgery: Do they possess an inherent antibacterial activity? A systematic review.
antibacterial properties
reconstructive surgery
regenerative medicine
silk fibroin
Journal
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
ISSN: 1524-475X
Titre abrégé: Wound Repair Regen
Pays: United States
ID NLM: 9310939
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
revised:
25
08
2022
received:
31
05
2022
accepted:
06
09
2022
pubmed:
16
9
2022
medline:
25
1
2023
entrez:
15
9
2022
Statut:
ppublish
Résumé
The field of reconstructive surgery encompasses a wide range of surgical procedures and regenerative approaches to treat various tissue types. Every surgical procedure is associated with the risk of surgical site infections, which are not only a financial burden but also increase patient morbidity. The surgical armamentarium in this area are biomaterials, particularly natural, biodegradable, biocompatible polymers, including the silk proteins fibroin (SF) and sericin (SS). Silk is known to be derived from silkworms and is mainly composed of 60-80% fibroin, which provides the structural form, and 15-35% sericin, which acts as a glue-like substance for the SF threads. Silk proteins possess most of the desired properties for biomedical applications, including biocompatibility, biodegradability, minimal immunogenicity, and tunable biomechanical behaviour. In an effort to alleviate or even prevent infections associated with the use of biomaterials in surgery, antibacterial/antimicrobial properties have been investigated in numerous studies. In this systematic review, the following question was addressed: Do silk proteins, SF and SS, possess an intrinsic antibacterial property and how could these materials be tailored to achieve such a property?
Substances chimiques
Anti-Bacterial Agents
0
Biocompatible Materials
0
Fibroins
9007-76-5
Sericins
0
Types de publication
Systematic Review
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-110Informations de copyright
© 2022 The Authors. Wound Repair and Regeneration published by Wiley Periodicals LLC on behalf of The Wound Healing Society.
Références
Sun W, Gregory DA, Tomeh MA, Zhao X. Silk fibroin as a functional biomaterial for tissue engineering. Int J Mol Sci. 2021;22(3):1499.
CDC. Surgical Site Infection Event (SSI). Center for Disease Control and Prevention; 2021.
Chouhan D, Mandal BB. Silk biomaterials in wound healing and skin regeneration therapeutics: from bench to bedside. Acta Biomater. 2020;103:24-51.
Jao D, Mou X, Hu X. Tissue regeneration: a silk road. J Funct Biomater. 2016;7(3):22.
van Turnhout A, Franke CJJ, Vriens-Nieuwenhuis EJC, van der Sluis WB. The use of SERI™ surgical scaffolds in direct-to-implant reconstruction after skin-sparing mastectomy: a retrospective study on surgical outcomes and a systematic review of current literature. J Plast Reconstr Aesthet Surg. 2018;71(5):644-650.
Kunz RI, Brancalhão RM, Ribeiro LF, Natali MR. Silkworm sericin: properties and biomedical applications. Biomed Res Int. 2016;2016:8175701.
Tao G, Wang Y, Cai R, et al. Design and performance of sericin/poly(vinyl alcohol) hydrogel as a drug delivery carrier for potential wound dressing application. Mater Sci Eng C Mater Biol Appl. 2019;101:341-351.
Zhang W, Chen L, Chen J, et al. Silk fibroin biomaterial shows safe and effective wound healing in animal models and a randomized controlled clinical trial. Adv Healthc Mater. 2017;6(10):1700121.
Ghensi P, Bettio E, Maniglio D, et al. Dental implants with anti-biofilm properties: a pilot study for developing a new Sericin-based coating. Materials (Basel). 2019;12(15):2429.
Napavichayanun S, Ampawong S, Harnsilpong T, Angspatt A, Aramwit P. Inflammatory reaction, clinical efficacy, and safety of bacterial cellulose wound dressing containing silk sericin and polyhexamethylene biguanide for wound treatment. Arch Dermatol Res. 2018;310(10):795-805.
Gogoi D, Choudhury AJ, Chutia J, et al. Development of advanced antimicrobial and sterilized plasma polypropylene grafted muga (Antheraea assama) silk as suture biomaterial. Biopolymers. 2014;101(4):355-365.
Li Z, Jiang Y, Cao G, Li J, Xue R, Gong C. Construction of transgenic silkworm spinning antibacterial silk with fluorescence. Mol Biol Rep. 2015;42(1):19-25.
Saviane A, Romoli O, Bozzato A, et al. Intrinsic antimicrobial properties of silk spun by genetically modified silkworm strains. Transgenic Res. 2018;27(1):87-101.
Babu PJ, Doble M, Raichur AM. Silver oxide nanoparticles embedded silk fibroin spuns: microwave mediated preparation, characterization and their synergistic wound healing and anti-bacterial activity. J Colloid Interface Sci. 2018;513:62-71.
Cao F, Zeng B, Zhu Y, et al. Porous ZnO modified silk sutures with dual light defined antibacterial, healing promotion and controlled self-degradation capabilities. Biomater Sci. 2020;8(1):250-255.
Dhas SP, Anbarasan S, Mukherjee A, Chandrasekaran N. Biobased silver nanocolloid coating on silk fibers for prevention of post-surgical wound infections. Int J Nanomedicine. 2015;10(Suppl 1):159.
Fei X, Jia M, Du X, et al. Green synthesis of silk fibroin-silver nanoparticle composites with effective antibacterial and biofilm-disrupting properties. Biomacromolecules. 2013;14(12):4483-4488.
Huang X-W, Wei J-J, Liu T, Zhang X-L, Bai S-M, Yang H-H. Silk fibroin-assisted exfoliation and functionalization of transition metal dichalcogenide nanosheets for antibacterial wound dressings. Nanoscale. 2017;9(44):17193-17198.
Patil S, Singh N. Antibacterial silk fibroin scaffolds with green synthesized silver nanoparticles for osteoblast proliferation and human mesenchymal stem cell differentiation. Colloids Surf B Biointerfaces. 2019;176:150-155.
Mehta AS, Singh BK, Singh N, et al. Chitosan silk-based three-dimensional scaffolds containing gentamicin-encapsulated calcium alginate beads for drug administration and blood compatibility. J Biomater Appl. 2015;29(9):1314-1325.
Sheikh FA, Woo JH, Mi Moon B, et al. Facile and highly efficient approach for the fabrication of multifunctional silk nanofibers containing hydroxyapatite and silver nanoparticles. J Biomed Mater Res A. 2014;102(10):3459-3469.
Arpaçay P, Türkan U. Development of antibiotic-loaded silk fibroin/hyaluronic acid polyelectrolyte film coated CoCrMo alloy. Biomed Tech (Berl). 2016;61(5):463-474.
Choudhury AJ, Gogoi D, Chutia J, et al. Controlled antibiotic-releasing Antheraea assama silk fibroin suture for infection prevention and fast wound healing. Surgery. 2016;159(2):539-547.
Dadras Chomachayi M, Solouk A, Akbari S, Sadeghi D, Mirahmadi F, Mirzadeh H. Electrospun nanofibers comprising of silk fibroin/gelatin for drug delivery applications: thyme essential oil and doxycycline monohydrate release study. J Biomed Mater Res A. 2018;106(4):1092-1103.
Hassani Besheli N, Mottaghitalab F, Eslami M, et al. Sustainable release of vancomycin from silk fibroin nanoparticles for treating severe bone infection in rat tibia osteomyelitis model. ACS Appl Mater Interfaces. 2017;9(6):5128-5138.
Liu Z, Zhu X, Tang R. Electrospun scaffold with sustained antibacterial and tissue-matched mechanical properties for potential application as functional mesh. Int J Nanomedicine. 2020;15:4991-5004.
Ojah N, Deka J, Haloi S, et al. Chitosan coated silk fibroin surface modified by atmospheric dielectric-barrier discharge (DBD) plasma: a mechanically robust drug release system. J Biomater Sci Polym Ed. 2019;30(13):1142-1160.
Sharma S, Bano S, Ghosh AS, et al. Silk fibroin nanoparticles support in vitro sustained antibiotic release and osteogenesis on titanium surface. Nanomed Nanotechnol Biol Med. 2016;12(5):1193-1204.
Shi C, Pu X, Zheng G, et al. An antibacterial and absorbable silk-based fixation material with impressive mechanical properties and biocompatibility. Sci Rep. 2016;6(1):1-12.
Zhou W, Jia Z, Xiong P, et al. Bioinspired and biomimetic AgNPs/gentamicin-embedded silk fibroin coatings for robust antibacterial and osteogenetic applications. ACS Appl Mater Interfaces. 2017;9(31):25830-25846.
Cai Z-X, Mo X-M, Zhang K-H, et al. Fabrication of chitosan/silk fibroin composite nanofibers for wound-dressing applications. Int J Mol Sci. 2010;11(9):3529-3539.
Çalamak S, Erdoğdu C, Özalp M, Ulubayram K. Silk fibroin based antibacterial bionanotextiles as wound dressing materials. Mater Sci Eng C. 2014;43:11-20.
Jo Y-Y, Kim D-W, Choi J-Y, Kim S-G. 4-Hexylresorcinol and silk sericin increase the expression of vascular endothelial growth factor via different pathways. Sci Rep. 2019;9(1):1-11.
Khan AUR, Nadeem M, Bhutto MA, et al. Physico-chemical and biological evaluation of PLCL/SF nanofibers loaded with oregano essential oil. Pharmaceutics. 2019;11(8):386.
Lv X, Li Z, Chen S, et al. Structural and functional evaluation of oxygenating keratin/silk fibroin scaffold and initial assessment of their potential for urethral tissue engineering. Biomaterials. 2016;84:99-110.
Patil PP, Bohara RA, Meshram JV, Nanaware SG, Pawar SH. Hybrid chitosan-ZnO nanoparticles coated with a sonochemical technique on silk fibroin-PVA composite film: a synergistic antibacterial activity. Int J Biol Macromol. 2019;122:1305-1312.
Song DW, Kim SH, Kim HH, Lee KH, Ki CS, Park YH. Multi-biofunction of antimicrobial peptide-immobilized silk fibroin nanofiber membrane: implications for wound healing. Acta Biomater. 2016;39:146-155.
Steinstraesser L, Rittig A, Hirsch T, Kesting MR, Steinau H-U, Jacobsen F. Colistin-loaded silk membranes against wound infection with Pseudomonas aeruginosa. Plast Reconstr Surg. 2011;127(5):1838-1846.
Zhou Q, Cui L, Ren L, et al. Preparation of a multifunctional fibroin-based biomaterial via laccase-assisted grafting of chitooligosaccharide. Int J Biol Macromol. 2018;113:1062-1072.
Gilotra S, Chouhan D, Bhardwaj N, Nandi SK, Mandal BB. Potential of silk sericin based nanofibrous mats for wound dressing applications. Mater Sci Eng C. 2018;90:420-432.
Xue R, Liu Y, Zhang Q, et al. Shape changes and interaction mechanism of Escherichia coli cells treated with sericin and use of a sericin-based hydrogel for wound healing. Appl Environ Microbiol. 2016;82(15):4663-4672.
Yang C, Xue R, Zhang Q, et al. Nanoclay cross-linked semi-IPN silk sericin/poly(NIPAm/LMSH) nanocomposite hydrogel: an outstanding antibacterial wound dressing. Mater Sci Eng C Mater Biol Appl. 2017;81:303-313.
Zhang F, Zhang Z, Zhu X, Kang E-T, Neoh K-G. Silk-functionalized titanium surfaces for enhancing osteoblast functions and reducing bacterial adhesion. Biomaterials. 2008;29(36):4751-4759.
Ai L, Wang Y, Tao G, et al. Polydopamine-based surface modification of ZnO nanoparticles on sericin/polyvinyl alcohol composite film for antibacterial application. Molecules. 2019;24(3):503.
Ai L, He H, Wang P, et al. Rational design and fabrication of ZnONPs functionalized sericin/PVA antimicrobial sponge. Int J Mol Sci. 2019;20(19):4796.
Gallo AL, Pollini M, Paladini F. A combined approach for the development of novel sutures with antibacterial and regenerative properties: the role of silver and silk sericin functionalization. J Mater Sci Mater Med. 2018;29(8):1-13.
Chaisabai W, Khamhaengpol A, Siri S. Sericins of mulberry and non-mulberry silkworms for eco-friendly synthesis of silver nanoparticles. Artif Cells Nanomed Biotechnol. 2018;46(3):536-543.
He H, Tao G, Wang Y, et al. In situ green synthesis and characterization of sericin-silver nanoparticle composite with effective antibacterial activity and good biocompatibility. Mater Sci Eng C. 2017;80:509-516.
Liu L, Cai R, Wang Y, et al. Polydopamine-assisted silver nanoparticle self-assembly on Sericin/agar film for potential wound dressing application. Int J Mol Sci. 2018;19(10):2875.
Wang Y, Cai R, Tao G, et al. A novel AgNPs/sericin/agar film with enhanced mechanical property and antibacterial capability. Molecules. 2018;23(7):1821.
Bakhsheshi-Rad HR, Ismail AF, Aziz M, et al. Development of the PVA/CS nanofibers containing silk protein sericin as a wound dressing: in vitro and in vivo assessment. Int J Biol Macromol. 2020;149:513-521.
Gao A, Chen H, Hou A, Xie K. Efficient antimicrobial silk composites using synergistic effects of violacein and silver nanoparticles. Mater Sci Eng C Mater Biol Appl. 2019;103:109821.
Thomas DS, Manoharan C, Rasalkar S, Mishra RK, Gopalapillai R. Recombinant expression of sericin-cecropin fusion protein and its functional activity. Biotechnol Lett. 2020;42(9):1673-1682.
Ampawong S, Aramwit P. A study of long-term stability and antimicrobial activity of chlorhexidine, polyhexamethylene biguanide, and silver nanoparticle incorporated in sericin-based wound dressing. J Biomater Sci Polym Ed. 2017;28(13):1286-1302.
Zhao R, Li X, Sun B, et al. Electrospun chitosan/sericin composite nanofibers with antibacterial property as potential wound dressings. Int J Biol Macromol. 2014;68:92-97.
Yang W, Cheng T, Ye M, et al. Functional divergence among silkworm antimicrobial peptide paralogs by the activities of recombinant proteins and the induced expression profiles. PLoS One. 2011;6(3):e18109.
Dong Z, Song Q, Zhang Y, et al. Structure, evolution, and expression of antimicrobial silk proteins, seroins in Lepidoptera. Insect Biochem Mol Biol. 2016;75:24-31.
Makvandi P, Ali GW, Della Sala F, Abdel-Fattah WI, Borzacchiello A. Hyaluronic acid/corn silk extract based injectable nanocomposite: a biomimetic antibacterial scaffold for bone tissue regeneration. Mater Sci Eng C Mater Biol Appl. 2020;107:110195.
Hoffman LR, D'Argenio DA, MacCoss MJ, Zhang Z, Jones RA, Miller SI. Aminoglycoside antibiotics induce bacterial biofilm formation. Nature. 2005;436(7054):1171-1175.
Tian W, Wang Y, Xu J, et al. Evaluation of the biomedical properties of a Ca+-conjugated silk fibroin porous material. Mater Sci Eng C. 2019;104:110003.