A self-assembled bilayer polypeptide-engineered hydrogel for spatiotemporal modulation of bactericidal and anti-inflammation process in osteomyelitis treatment.

Anti-Bacterial Agents / chemistry Dimaprit / analogs & derivatives Humans Hydrogels / chemistry Osteomyelitis / drug therapy Peptides / pharmacology Staphylococcus aureus
Antibacterial Bone repairing Engineered polypeptide hydrogel Osteomyelitis Spatiotemporal regulation

Journal

Journal of nanobiotechnology
ISSN: 1477-3155
Titre abrégé: J Nanobiotechnology
Pays: England
ID NLM: 101152208

Informations de publication

Date de publication:
15 Sep 2022
Historique:
received: 04 06 2022
accepted: 28 08 2022
entrez: 15 9 2022
pubmed: 16 9 2022
medline: 20 9 2022
Statut: epublish

Résumé

Drug resistance of pathogens and immunosuppression are the main causes of clinical stagnation of osteomyelitis. The ideal treatment strategy for osteomyelitis is to achieve both efficient antibacterial and bone healing through spatiotemporal modulation of immune microenvironment. In this study, a bilayer hydrogel based on genetically engineered polypeptide AC The in vitro and in vivo results showed that the AA-MAR hydrogel not only realized efficient photodynamic therapy of S. aureus infection, but also promoted the transformation of immune microenvironment to fulfill the different needs of each stage, which ultimately improved bone regeneration and mechanical properties post-surgery. This work presents an approach for spatiotemporal modulation of immune microenvironment in the treatment of osteomyelitis.

Sections du résumé

BACKGROUND BACKGROUND
Drug resistance of pathogens and immunosuppression are the main causes of clinical stagnation of osteomyelitis. The ideal treatment strategy for osteomyelitis is to achieve both efficient antibacterial and bone healing through spatiotemporal modulation of immune microenvironment.
METHODS METHODS
In this study, a bilayer hydrogel based on genetically engineered polypeptide AC
RESULTS RESULTS
The in vitro and in vivo results showed that the AA-MAR hydrogel not only realized efficient photodynamic therapy of S. aureus infection, but also promoted the transformation of immune microenvironment to fulfill the different needs of each stage, which ultimately improved bone regeneration and mechanical properties post-surgery.
CONCLUSION CONCLUSIONS
This work presents an approach for spatiotemporal modulation of immune microenvironment in the treatment of osteomyelitis.

Identifiants

DOI: 10.1186/s12951-022-01614-3 PMID: 36109760 PMC: PMC9479290
pubmed: 36109760
doi: 10.1186/s12951-022-01614-3
pii: 10.1186/s12951-022-01614-3
pmc: PMC9479290
doi:

Substances chimiques

Anti-Bacterial Agents 0
Hydrogels 0
Peptides 0
APT 7320-57-2
Dimaprit ZZQ699148P

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

416

Informations de copyright

© 2022. The Author(s).

Références

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Auteurs

Xiaoting Xie (X)

Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, People's Republic of China.

Jiemao Wei (J)

Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei, People's Republic of China.

Bin Zhang (B)

Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, People's Republic of China.

Wei Xiong (W)

Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei, People's Republic of China. xcxgreatwellus@hotmail.com.

Zhiyi He (Z)

Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei, People's Republic of China.

Yayun Zhang (Y)

Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei, People's Republic of China.

Chenghao Gao (C)

Department of Orthopedic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei, People's Republic of China.

Yuandi Zhao (Y)

Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, People's Republic of China. zydi@mail.hust.edu.cn.
Key Laboratory of Biomedical Photonics (HUST), Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, People's Republic of China. zydi@mail.hust.edu.cn.

Bo Liu (B)

Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, People's Republic of China. lbyang@mail.hust.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › A self-assembled bilayer...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Thiourée › Dimaprit › A self-assembled bilayer...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A self-assembled bilayer...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › A self-assembled bilayer...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Infections osseuses › Ostéomyélite › A self-assembled bilayer...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › A self-assembled bilayer...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › A self-assembled bilayer...