Unravelling the pharmacokinetics of aflatoxin B1:
CYP450 enzymes
LC–MS/MS
Michaelis–Menten constant
aflatoxin B1
human liver microsomes
in vitro
mycotoxins
pharmacokinetic
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
07
2022
accepted:
04
08
2022
entrez:
16
9
2022
pubmed:
17
9
2022
medline:
17
9
2022
Statut:
epublish
Résumé
Mycotoxins, fungal secondary metabolites, are ubiquitously present in food commodities. Acute exposure to high levels or chronic exposure to low levels has an impact on the human body. The phase I metabolism in the human liver, performed by cytochrome P450 (CYP450) enzymes, is accountable for more than 80% of the overall metabolism of exogenous and endogenous compounds. Mycotoxins are (partially) metabolized by CYP450 enzymes. In this study,
Identifiants
pubmed: 36110298
doi: 10.3389/fmicb.2022.988083
pmc: PMC9469084
doi:
Types de publication
Journal Article
Langues
eng
Pagination
988083Informations de copyright
Copyright © 2022 Lootens, De Boevre, Gasthuys, Van Bocxlaer, Vermeulen and De Saeger.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Biosci Rep. 2017 Nov 21;37(6):
pubmed: 29054967
Chem Res Toxicol. 2006 Apr;19(4):577-86
pubmed: 16608170
Drug Metab Dispos. 2002 Dec;30(12):1311-9
pubmed: 12433797
Crit Rev Food Sci Nutr. 2020;60(16):2773-2789
pubmed: 31478403
Int J Cancer. 2006 Jun 1;118(11):2665-71
pubmed: 16385575
Genome Res. 2010 Aug;20(8):1020-36
pubmed: 20538623
Drug Metab Dispos. 2015 Sep;43(9):1336-40
pubmed: 26070839
Compr Rev Food Sci Food Saf. 2020 Jul;19(4):1449-1464
pubmed: 33337079
Xenobiotica. 1988 Jan;18(1):95-104
pubmed: 3128014
Pharmacology. 1978;17(4):191-200
pubmed: 693568
Chemosphere. 2018 Jul;202:538-548
pubmed: 29587235
Drug Metab Dispos. 1998 Mar;26(3):207-15
pubmed: 9492382
Drug Metab Dispos. 2016 May;44(5):781-91
pubmed: 26956641
Metabolites. 2019 Jul 27;9(8):
pubmed: 31357617
Drug Metab Rev. 2009;41(2):89-295
pubmed: 19514967
Biochim Biophys Acta. 2007 Mar;1770(3):330-44
pubmed: 16978787
Br J Anaesth. 1987 May;59(5):548-56
pubmed: 3580236
Drug Metab Dispos. 2010 Jul;38(7):1147-58
pubmed: 20368326
Front Pharmacol. 2019 Apr 16;10:399
pubmed: 31105561
Adv Food Nutr Res. 2019;89:297-345
pubmed: 31351529
Cancer Prev Res (Phila). 2009 Dec;2(12):1015-22
pubmed: 19952359
Xenobiotica. 2010 Apr;40(4):235-44
pubmed: 20105059
Xenobiotica. 2000 Apr;30(4):327-43
pubmed: 10821163
Drug Metab Dispos. 2002 Aug;30(8):892-6
pubmed: 12124306
Cancer Res. 1994 Jan 1;54(1):101-8
pubmed: 8261428
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010 Jun;154(2):103-16
pubmed: 20668491
Clin Microbiol Rev. 2003 Jul;16(3):497-516
pubmed: 12857779
Toxicol Appl Pharmacol. 1996 Dec;141(2):595-606
pubmed: 8975785
J Clin Pharmacol. 1996 Sep;36(9):783-91
pubmed: 8889898
J Pharm Anal. 2014 Aug;4(4):270-278
pubmed: 29403890
Daru. 2012 Sep 10;20(1):38
pubmed: 23351782
Mol Nutr Food Res. 2020 Jul;64(13):e2000063
pubmed: 32421213
J Pharm Sci. 2019 Jul;108(7):2500-2504
pubmed: 30817922
PLoS One. 2014 Feb 26;9(2):e89752
pubmed: 24587011
Front Pharmacol. 2019 May 07;10:467
pubmed: 31133854
Sci Rep. 2019 Jun 25;9(1):9233
pubmed: 31239454
J Pharm Sci. 2004 Jun;93(6):1537-44
pubmed: 15124211
Eur J Drug Metab Pharmacokinet. 2017 Jun;42(3):537-543
pubmed: 27317395
Drug Metab Dispos. 2016 Mar;44(3):343-51
pubmed: 26681736
Biochem Pharmacol. 1981 Sep 1;30(17):2451-6
pubmed: 21043244