A Unique Case of Squamous Cell Carcinoma Presenting Within a Lesion of Granuloma Annulare.
cutaneous squamous cell
dermatopathology
general dermatology
granuloma annulare
medical dermatology
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
accepted:
09
08
2022
entrez:
16
9
2022
pubmed:
17
9
2022
medline:
17
9
2022
Statut:
epublish
Résumé
Granuloma annulare (GA) is a common benign granulomatous inflammatory disorder of the dermis or subcutis with classic morphologic and histologic presentation. Common clinical subtypes of granuloma annulare include localized, generalized, subcutaneous, perforating, and patch types. A biopsy is critical in cases of granuloma annulare with atypical features. We present a case of a 58-year-old male who presented with an annular scaly erythematous plaque on the right dorsal hand. Shave biopsy demonstrated irregular nests of mildly atypical squamous epithelium present within the superficial dermis, with abundant histiocytes and multinucleated giant cells arranged in palisades peripherally. These findings were consistent with invasive well-differentiated squamous cell carcinoma (SCC) with surrounding granuloma annulare. This case highlights a unique presentation in which clinicopathologic correlation is critical prior to arriving at a correct diagnosis.
Identifiants
pubmed: 36110441
doi: 10.7759/cureus.27845
pmc: PMC9462656
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e27845Informations de copyright
Copyright © 2022, Zabel et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Am J Clin Dermatol. 2022 Jan;23(1):37-50
pubmed: 34495491
Arch Dermatol. 1992 May;128(5):649-52
pubmed: 1374225
JAMA Dermatol. 2021 Jul 01;157(7):824-830
pubmed: 34106215
Dermatol Clin. 2015 Jul;33(3):315-29
pubmed: 26143416
Adv Skin Wound Care. 2020 Dec;33(12):629-634
pubmed: 33208661
J Eur Acad Dermatol Venereol. 2015 Aug;29(8):1467-80
pubmed: 25651003
Am J Clin Dermatol. 2018 Jun;19(3):333-344
pubmed: 29230666
Hautarzt. 2015 Nov;66(11):867-75; quiz 876-7
pubmed: 26487494
J Am Acad Dermatol. 2016 Sep;75(3):467-479
pubmed: 27543210
Dermatol Online J. 2021 Apr 15;27(4):
pubmed: 33999585
J Am Acad Dermatol. 2016 Sep;75(3):457-465
pubmed: 27543209