Reduction of Mature B Cells and Immunoglobulins Results in Increased Trabecular Bone.
B LYMPHOCYTES
IMMUNOGLOBULIN
OSTEOCLASTS
OSTEOIMMUNOLOGY
TRABECULAR BONE
Journal
JBMR plus
ISSN: 2473-4039
Titre abrégé: JBMR Plus
Pays: England
ID NLM: 101707013
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
13
04
2022
revised:
07
07
2022
accepted:
22
07
2022
entrez:
16
9
2022
pubmed:
17
9
2022
medline:
17
9
2022
Statut:
epublish
Résumé
Inflammation has a significant effect on bone remodeling and can result in bone loss via increased stimulation of osteoclasts. Activated immunoglobulins, especially autoantibodies, can increase osteoclastogenesis and are associated with pathological bone loss. Whether immunoglobulins and mature B lymphocytes are important for general bone architecture has not been completely determined. Here we demonstrate, using a transgenic mouse model, that reduction of mature B cells and immunoglobulins leads to increased trabecular bone mass compared to wild-type (WT) littermate controls. This bone effect is associated with a decrease in the number of osteoclasts and reduced bone resorption, despite decreased expression of osteoprotegerin. We also demonstrate that the reduction of mature B cells and immunoglobulins do not prevent bone loss caused by estrogen deficiency or arthritis compared to WT littermate controls. In conclusion, the reduction of mature B cells and immunoglobulins results in disturbed regulation of trabecular bone turnover in healthy conditions but is dispensable for pathological bone loss. © 2022 The Authors.
Identifiants
pubmed: 36111205
doi: 10.1002/jbm4.10670
pii: JBM410670
pmc: PMC9465004
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10670Informations de copyright
© 2022 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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