Differential contribution of alpha and beta cell dysfunction to impaired fasting glucose and impaired glucose tolerance.
Alpha cell function
Beta cell function
Deconvolution
Glucagon suppression
Impaired fasting glucose
Impaired insulin action
Insulin secretion
Prediabetes
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
18
05
2022
accepted:
02
08
2022
pmc-release:
01
01
2024
pubmed:
17
9
2022
medline:
15
12
2022
entrez:
16
9
2022
Statut:
ppublish
Résumé
People with isolated impaired fasting glucose (IFG) have normal beta cell function. We hypothesised that an increased glucose threshold for beta cell secretion explains IFG. We used graded glucose infusion to examine the relationship of insulin secretion rate (ISR) and glucagon secretion rate (GSR) with rising glucose. We studied 39 non-diabetic individuals (53 ± 2 years, BMI 30 ± 1 kg/m The relationship of ISR with glucose was linear and the threshold for insulin secretion in isolated IFG did not differ from that in people with normal fasting glucose and normal glucose tolerance. GSR exhibited a single-exponential relationship with glucose that could be characterised by G These data show that, in non-diabetic humans, alpha cell dysfunction contributes to the pathogenesis of IFG independently of defects in insulin secretion. We also describe a new index that quantifies the suppression of glucagon secretion by glucose.
Identifiants
pubmed: 36112169
doi: 10.1007/s00125-022-05794-3
pii: 10.1007/s00125-022-05794-3
pmc: PMC9742343
mid: NIHMS1845110
doi:
Substances chimiques
Glucagon
9007-92-5
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
201-212Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK078646
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK126206
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Nat Rev Endocrinol. 2009 Aug;5(8):429-36
pubmed: 19564886
Diabetes Res Clin Pract. 2017 Jan;123:173-180
pubmed: 28043048
J Clin Invest. 2014 Feb;124(2):499-508
pubmed: 24463454
Diabetes. 2000 Feb;49(2):272-83
pubmed: 10868944
Diabetes Care. 1998 Sep;21(9):1408-13
pubmed: 9727885
Diabetologia. 2008 May;51(5):853-61
pubmed: 18317726
Diabetes. 2007 Apr;56(4):1113-9
pubmed: 17395750
Diabetes. 2016 Nov;65(11):3473-3481
pubmed: 27504013
Curr Opin Clin Nutr Metab Care. 2010 Jul;13(4):471-7
pubmed: 20473152
N Engl J Med. 2002 Feb 7;346(6):393-403
pubmed: 11832527
Diabetes Care. 2008 Feb;31(2):347-52
pubmed: 18000184
Am J Epidemiol. 2013 Jun 15;177(12):1418-29
pubmed: 23707958
Diabetes. 2014 Apr;63(4):1203-13
pubmed: 24651807
Metabolism. 2020 Apr;105:154175
pubmed: 32045582
Diabetes. 2006 May;55(5):1430-5
pubmed: 16644701
Endocrinol Metab Clin North Am. 2021 Sep;50(3):319-336
pubmed: 34399948
Am J Physiol. 1991 Jan;260(1 Pt 1):E67-74
pubmed: 1987794
N Engl J Med. 1996 Mar 21;334(12):777-83
pubmed: 8592553
Am J Physiol Endocrinol Metab. 2021 Jan 1;320(1):E71-E77
pubmed: 33135460
Diabetes Res Clin Pract. 2020 Jul;165:108233
pubmed: 32497744
Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E2-10
pubmed: 11120653
Clin Chem Lab Med. 2007;45(9):1180-5
pubmed: 17635074
Am J Physiol. 1999 Aug;277(2):E283-90
pubmed: 10444424
Diabetes. 1998 Mar;47(3):307-15
pubmed: 9519733
Diabetes. 2000 Apr;49(4):611-7
pubmed: 10871199
J Clin Endocrinol Metab. 2011 Dec;96(12):3811-21
pubmed: 21956413
Diabetologia. 2015 Nov;58(11):2663-70
pubmed: 26254577
Nat Genet. 2010 Feb;42(2):142-8
pubmed: 20081857
Metabolism. 2017 Mar;68:55-63
pubmed: 28183453
Obes Surg. 2011 Mar;21(3):351-5
pubmed: 21128002
J Clin Endocrinol Metab. 2016 Dec;101(12):4816-4824
pubmed: 27603902
J Clin Invest. 1994 Mar;93(3):1120-30
pubmed: 8132752
Diabetes. 2016 Feb;65(2):371-80
pubmed: 26525881
Diabetes Care. 2016 Jan;39(1):50-2
pubmed: 26109503
J Clin Endocrinol Metab. 2018 Jan 1;103(1):314-319
pubmed: 29126197
Clin Endocrinol (Oxf). 2012 Feb;76(2):212-9
pubmed: 21707690
Diabetes. 2006 Dec;55(12):3536-49
pubmed: 17130502
Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E865-73
pubmed: 27072496
J Clin Endocrinol Metab. 2012 Sep;97(9):3285-91
pubmed: 22761463
Diabetes Care. 1990 Sep;13(9):992-1010
pubmed: 2226113
Diabetes. 1992 Mar;41(3):368-77
pubmed: 1551497
Diabetes. 2001 Jun;50(6):1351-62
pubmed: 11375336