Targeting hepatic oxidative stress rescues bone loss in liver fibrosis.

Humans Mice Animals Interleukin-17 / metabolism Liver Cirrhosis / metabolism Hepatocytes / metabolism Oxidative Stress Fibrosis
Chronic liver diseases Hepatic osteodystrophy Interleukin 17 Neutrophils Reactive oxidative species Stanniocalcin 1

Journal

Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730

Informations de publication

Date de publication:
12 2022
Historique:
received: 09 03 2022
revised: 01 09 2022
accepted: 09 09 2022
pubmed: 17 9 2022
medline: 21 12 2022
entrez: 16 9 2022
Statut: ppublish

Résumé

Chronic liver diseases often involve metabolic damage to the skeletal system. The underlying mechanism of bone loss in chronic liver diseases remains unclear, and appropriate therapeutic options, except for orthotopic liver transplantation, have proved insufficient for these patients. This study aimed to investigate the efficacy and mechanism of transplantation of immature hepatocyte-like cells converted from stem cells from human exfoliated deciduous teeth (SHED-Heps) in bone loss of chronic liver fibrosis. Mice that were chronically treated with CCl SHED-Hep transplantation (SHED-HepTx) improved trabecular bone loss and liver fibrosis in chronic CCl These findings suggest that targeting hepatic ROS provides a novel approach to treat bone loss resulting from chronic liver diseases.

Identifiants

DOI: 10.1016/j.molmet.2022.101599 PMID: 36113772 PMC: PMC9515604
pubmed: 36113772
pii: S2212-8778(22)00168-5
doi: 10.1016/j.molmet.2022.101599
pmc: PMC9515604
pii:
doi:

Substances chimiques

Interleukin-17 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101599

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier GmbH.. All rights reserved.

Auteurs

Soichiro Sonoda (S)

Department of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, Fukuoka, Japan.

Sara Murata (S)

Department of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, Fukuoka, Japan.

Haruyoshi Yamaza (H)

Department of Pediatric Dentistry, Kyushu University Graduate School of Dental Science, Fukuoka, Japan.

Ratih Yuniartha (R)

Department of Anatomy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Junko Fujiyoshi (J)

Department of Pediatrics, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Koichiro Yoshimaru (K)

Department of Pediatric Surgery, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Toshiharu Matsuura (T)

Department of Pediatric Surgery, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Yoshinao Oda (Y)

Department of Anatomic Pathology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Shouichi Ohga (S)

Department of Pediatrics, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Tasturo Tajiri (T)

Department of Pediatric Surgery, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Tomoaki Taguchi (T)

Department of Pediatric Surgery, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; Fukuoka College of Health Sciences, Fukuoka, Japan.

Takayoshi Yamaza (T)

Department of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, Fukuoka, Japan. Electronic address: yamazata@dent.kyushu-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Targeting hepatic oxidative stress rescues...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Targeting hepatic oxidative stress rescues...
questionsmedicales.fr › Eucaryotes › Animaux › Targeting hepatic oxidative stress rescues...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-17 › Targeting hepatic oxidative stress rescues...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Cirrhose du foie › Targeting hepatic oxidative stress rescues...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Targeting hepatic oxidative stress rescues...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Targeting hepatic oxidative stress rescues...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Targeting hepatic oxidative stress rescues...