Additional value of a triggerlist as selection criterion in identifying patients at high risk of medication-related hospital admission: a retrospective cohort study.
Aged
Hospitalization
Medication errors
Polypharmacy
Triggerlist
Journal
International journal of clinical pharmacy
ISSN: 2210-7711
Titre abrégé: Int J Clin Pharm
Pays: Netherlands
ID NLM: 101554912
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
13
04
2022
accepted:
12
06
2022
pubmed:
18
9
2022
medline:
2
11
2022
entrez:
17
9
2022
Statut:
ppublish
Résumé
Of all hospital admissions in older patients, 10-30% seem to be medication-related. However, medication-related admissions are often unidentified in clinical practice. To increase the identification of medication-related hospital admissions in older patients a triggerlist is published in the Dutch guideline for polypharmacy. To assess whether the triggerlist has value as selection criterion to identify patients at high risk of medication-related hospital admissions. This retrospective cohort study was carried out in 100 older (≥ 60 years) patients with polypharmacy and having two triggers from the triggerlist. The admissions were assessed as either possibly or unlikely medication-related according to the Assessment Tool for identifying Hospital Admissions Related to Medications. Of all the admissions 48% were classified as possibly medication-related. Patients with a possible medication-related hospital admission were more likely to have an impaired renal function (p = 0.015), but no differences with regard to age, sex, comorbidity or number of medicines were found. The high prevalence of medication-related hospital admissions, suggests the triggerlist may have added value as selection criterion in a cohort of older patients with polypharmacy and can be used to improve the identification of a population at high risk of medication-related hospital admissions.
Sections du résumé
BACKGROUND
BACKGROUND
Of all hospital admissions in older patients, 10-30% seem to be medication-related. However, medication-related admissions are often unidentified in clinical practice. To increase the identification of medication-related hospital admissions in older patients a triggerlist is published in the Dutch guideline for polypharmacy.
AIM
OBJECTIVE
To assess whether the triggerlist has value as selection criterion to identify patients at high risk of medication-related hospital admissions.
METHOD
METHODS
This retrospective cohort study was carried out in 100 older (≥ 60 years) patients with polypharmacy and having two triggers from the triggerlist. The admissions were assessed as either possibly or unlikely medication-related according to the Assessment Tool for identifying Hospital Admissions Related to Medications.
RESULTS
RESULTS
Of all the admissions 48% were classified as possibly medication-related. Patients with a possible medication-related hospital admission were more likely to have an impaired renal function (p = 0.015), but no differences with regard to age, sex, comorbidity or number of medicines were found.
CONCLUSION
CONCLUSIONS
The high prevalence of medication-related hospital admissions, suggests the triggerlist may have added value as selection criterion in a cohort of older patients with polypharmacy and can be used to improve the identification of a population at high risk of medication-related hospital admissions.
Identifiants
pubmed: 36115001
doi: 10.1007/s11096-022-01447-y
pii: 10.1007/s11096-022-01447-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1205-1210Subventions
Organisme : ZonMw
ID : 848016012
Pays : Netherlands
Organisme : ZonMw
ID : 848016012
Pays : Netherlands
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
Références
van Marum RJ, Verduijn MM, de Vries-Moeselaar AC, et al. Polyfarmacie bij ouderen. Richtlijndatabase.nl. 2020. Cited 01 April 2022. https://richtlijnendatabase.nl/richtlijn/polyfarmacie_bij_ouderen/polyfarmacie_bij_ouderen_-_korte_beschrijving.html#tab-content-accountability . Accessed 1 Apr 2022.
Leendertse AJ, Egberts AC, Stoker LJ, HARM Study Group, et al. Frequency of and risk factors for preventable medication-related hospital admissions in the Netherlands. Arch Intern Med. 2008;168:1890–6.
pubmed: 18809816
El Morabet N, Uitvlugt EB, van den Bemt BJF, et al. Prevalence and preventability of drug-related hospital readmissions: a systematic review. J Am Geriatr Soc. 2018;66:602–8.
doi: 10.1111/jgs.15244
pubmed: 29468640
Chan M, Nicklason F, Vial JH. Adverse drug events as a cause of hospital admission in the elderly. Intern Med J. 2001;31:199–205.
doi: 10.1046/j.1445-5994.2001.00044.x
pubmed: 11456032
McLachlan CY, Yi M, Ling A, et al. Adverse drug events are a major cause of acute medical admission. Intern Med J. 2014;44:633–8.
doi: 10.1111/imj.12455
pubmed: 24750276
Oscanoa TJ, Lizaraso F, Carvajal A. Hospital admissions due to adverse drug reactions in the elderly. A meta-analysis. Eur J Clin Pharmacol. 2017;73:759–70.
doi: 10.1007/s00228-017-2225-3
pubmed: 28251277
Kempen TGH, Hedström M, Olsson H, et al. Assessment tool for hospital admissions related to medications: development and validation in older patients. Int J Clin Pharm. 2019;41:198–206.
doi: 10.1007/s11096-018-0768-8
pubmed: 30585296
Linkens AEMJH, Milosevic V, van der Kuy PHM, et al. Medication-related hospital admissions and readmissions in older patients: an overview of literature. Int J Clin Pharm. 2020;42:1243–51.
doi: 10.1007/s11096-020-01040-1
pubmed: 32472324
pmcid: 7522062
Leendertse AJ, Visser D, Egberts AC, et al. The relationship between study characteristics and the prevalence of medication-related hospitalizations: a literature review and novel analysis. Drug Saf. 2010;33:233–44.
doi: 10.2165/11319030-000000000-00000
pubmed: 20158287
Linkens AEMJH, Milosevic V, van Nie N, et al. Control in the hospital by extensive clinical rules for unplanned hospitalizations in older patients (CHECkUP); study design of a multicentre randomized study. BMC Geriatr. 2022;22:36.
doi: 10.1186/s12877-021-02723-8
pubmed: 35012478
pmcid: 8744034
Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–83.
doi: 10.1016/0021-9681(87)90171-8
pubmed: 3558716
van der Hooft CS, Dieleman JP, Siemes C, et al. Adverse drug reaction-related hospitalisations: a population-based cohort study. Pharmacoepidemiol Drug Saf. 2008;17:365–71.
doi: 10.1002/pds.1565
pubmed: 18302300
Warlé-van Herwaarden MF, Valkhoff VE, Herings RM, et al. Quick assessment of drug-related admissions over time (QUADRAT study). Pharmacoepidemiol Drug Saf. 2015;24:495–503.
doi: 10.1002/pds.3747
pubmed: 25683383
Reijers EMC, van Strien AM, Derijks HJ, et al. Geneesmiddelgerelateerde SEH-bezoeken zonder opname bij ouderen. Nederlands Platform voor Farmaceutisch Onderzoek. 2021;6: a1734.
Saeed D, Carter G, Parsons C. Interventions to improve medicines optimisation in frail older patients in secondary and acute care settings: a systematic review of randomised controlled trials and non-randomised studies. Int J Clin Pharm. 2022;44:15–26.
doi: 10.1007/s11096-021-01354-8
pubmed: 34800255
Lea M, Mowe M, Mathiesen L, et al. Prevalence and risk factors of drug-related hospitalizations in multimorbid patients admitted to an internal medicine ward. PLoS ONE. 2019;14:e0220071.
doi: 10.1371/journal.pone.0220071
pubmed: 31329634
pmcid: 6645516
Zerah L, Henrard S, Thevelin S, et al. Performance of a trigger tool for detecting drug-related hospital admissions in older people: analysis from the OPERAM trial [published correction appears in Age Ageing. 2022;51(3):]. Age Ageing. 2022;51:afab196.
doi: 10.1093/ageing/afab196
pubmed: 34794171
Coppes T, van der Kloes J, Dalleur O, et al. Identifying medication-related readmissions: two students using tools vs a multidisciplinary panel. Int J Clin Pract. 2021;75(11):e14768.
doi: 10.1111/ijcp.14768
pubmed: 34486783