Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catechol-O-methyltransferase inhibitor.

Humans Catechol O-Methyltransferase / chemistry Antioxidants / pharmacology Catechol O-Methyltransferase Inhibitors / pharmacology Monoamine Oxidase Inhibitors / chemistry Monoamine Oxidase / metabolism Catechols / pharmacology Parkinson Disease Oxidation-Reduction Amides
Antioxidants Caffeic acid Catechol-O-Methyltransferase Monoamine oxidase Neuroprotection Parkinson's disease

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
05 Dec 2022
Historique:
received: 25 07 2022
revised: 28 08 2022
accepted: 01 09 2022
pubmed: 19 9 2022
medline: 2 11 2022
entrez: 18 9 2022
Statut: ppublish

Résumé

Increased oxidative stress (OS) and depletion of nigrostriatal dopamine (DA) are closely linked to the neurodegeneration observed in Parkinson's Disease (PD). Caffeic acid (CA)-based antioxidants were developed, and their inhibitory activities towards monoamine oxidases (MAOs) and catechol O-methyltransferases (COMT) were screened. The results showed that the incorporation of an extra double bond maintained or even boosted the antioxidant properties of CA. α-CN derivatives displayed redox potentials (E

Identifiants

DOI: 10.1016/j.ejmech.2022.114740 PMID: 36116233
pubmed: 36116233
pii: S0223-5234(22)00642-0
doi: 10.1016/j.ejmech.2022.114740
pii:
doi:

Substances chimiques

Catechol O-Methyltransferase EC 2.1.1.6
Antioxidants 0
Catechol O-Methyltransferase Inhibitors 0
caffeic acid U2S3A33KVM
Monoamine Oxidase Inhibitors 0
Monoamine Oxidase EC 1.4.3.4
catechol LF3AJ089DQ
Catechols 0
Amides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114740

Informations de copyright

Copyright © 2022 Elsevier Masson SAS. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interest or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Daniel Chavarria (D)

CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal.

Sofia Benfeito (S)

CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal.

Pedro Soares (P)

CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal.

Carla Lima (C)

CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal.

Jorge Garrido (J)

CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal; Department of Chemical Engineering, School of Engineering (ISEP), Polytechnic of Porto, 4200-072, Porto, Portugal.

Paula Serrão (P)

Department of Biomedicine - Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, 4200-319, Porto, Portugal; MedInUP - Center for Drug Discovery and Innovative Medicines, University of Porto, 4200-319, Porto, Portugal.

Patrício Soares-da-Silva (P)

Department of Biomedicine - Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, 4200-319, Porto, Portugal; MedInUP - Center for Drug Discovery and Innovative Medicines, University of Porto, 4200-319, Porto, Portugal.

Fernando Remião (F)

UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

Paulo J Oliveira (PJ)

CNC - Center for Neuroscience and Cell Biology, CIBB-Center for Innovative Biomedicine and Biotechnology. University of Coimbra, UC Biotech Building, Cantanhede, Portugal.

Fernanda Borges (F)

CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal. Electronic address: fborges@fc.up.pt.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Boosting caffeic acid performance as...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › Catechol O-methyltransferase › Boosting caffeic acid performance as...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Boosting caffeic acid performance as...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Antidyskinésiques › Antiparkinsoniens › Inhibiteurs de la catéchol O-méthyltransférase › Boosting caffeic acid performance as...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la monoamine oxydase › Boosting caffeic acid performance as...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Monoamine oxidase › Boosting caffeic acid performance as...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Boosting caffeic acid performance as...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Boosting caffeic acid performance as...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Boosting caffeic acid performance as...
questionsmedicales.fr › Composés chimiques organiques › Amides › Boosting caffeic acid performance as...