A systematic review of the correlation between Trichomonas vaginalis infection and infertility.

Fertility Humans Infertility / complications Male Reproduction Semen Trichomonas Infections / complications Trichomonas vaginalis
Correlation Infection Infertility Systematic review Trichomonas vaginalis

Journal

Acta tropica
ISSN: 1873-6254
Titre abrégé: Acta Trop
Pays: Netherlands
ID NLM: 0370374

Informations de publication

Date de publication:
Dec 2022
Historique:
received: 11 07 2022
revised: 14 09 2022
accepted: 14 09 2022
pubmed: 19 9 2022
medline: 18 10 2022
entrez: 18 9 2022
Statut: ppublish

Résumé

Trichomonas vaginalis (T. vaginalis) is an extracellular flagellated protozoan parasitizing the human genital and urinary tracts. T. vaginalis infection impacts human reproductive function, but whether it causes infertility is still a matter of debate. In this work, we consulted 205 relevant articles, which were classified into three categories: epidemiological investigations (100), review articles (43), and research articles (62). RevMan 5.4 was used to conduct a meta-analysis of the articles reporting epidemiological investigations comparing the incidence of T. vaginalis infection between infertile and fertile groups. Review and research articles were used to summarize the pathogenesis of infertility caused by T. vaginalis. The results indicated that rate of T. vaginalis infection in the infertile group was significantly higher than that in the fertile group. Moreover, the epidemiological surveys showed that the infertility rates of population infected with T. vaginalis were significantly higher than that of population without T. vaginalis infection. Nine out of ten (90%) related review articles stated that T. vaginalis infection causes infertility, and the review and research articles indicated the main pathogenic mechanisms of infertility caused by T. vaginalis were as follows: T. vaginalis impairs sperm quality, resulting in infertility; the immune response triggered by T. vaginalis infection impacts human reproductive function. Our results confirm that there is a correlation between T. vaginalis infection and infertility, and T. vaginalis infection can lead to infertility. The study provides a foundation for further investigations into its pathogenesis.

Sections du résumé

BACKGROUND BACKGROUND
Trichomonas vaginalis (T. vaginalis) is an extracellular flagellated protozoan parasitizing the human genital and urinary tracts. T. vaginalis infection impacts human reproductive function, but whether it causes infertility is still a matter of debate.
METHODS METHODS
In this work, we consulted 205 relevant articles, which were classified into three categories: epidemiological investigations (100), review articles (43), and research articles (62). RevMan 5.4 was used to conduct a meta-analysis of the articles reporting epidemiological investigations comparing the incidence of T. vaginalis infection between infertile and fertile groups. Review and research articles were used to summarize the pathogenesis of infertility caused by T. vaginalis.
RESULTS RESULTS
The results indicated that rate of T. vaginalis infection in the infertile group was significantly higher than that in the fertile group. Moreover, the epidemiological surveys showed that the infertility rates of population infected with T. vaginalis were significantly higher than that of population without T. vaginalis infection. Nine out of ten (90%) related review articles stated that T. vaginalis infection causes infertility, and the review and research articles indicated the main pathogenic mechanisms of infertility caused by T. vaginalis were as follows: T. vaginalis impairs sperm quality, resulting in infertility; the immune response triggered by T. vaginalis infection impacts human reproductive function.
CONCLUSION CONCLUSIONS
Our results confirm that there is a correlation between T. vaginalis infection and infertility, and T. vaginalis infection can lead to infertility. The study provides a foundation for further investigations into its pathogenesis.

Identifiants

DOI: 10.1016/j.actatropica.2022.106693 PMID: 36116548
pubmed: 36116548
pii: S0001-706X(22)00385-0
doi: 10.1016/j.actatropica.2022.106693
pii:
doi:

Types de publication

Journal Article Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

106693

Informations de copyright

Copyright © 2022. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no competing interests.

Auteurs

Zhenchao Zhang (Z)

Department of Pathogenic Biology, Xinxiang Key Laboratory of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China.

Yuhua Li (Y)

Department of Pathogenic Biology, Xinxiang Key Laboratory of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China.

Haoran Lu (H)

Department of Pathogenic Biology, Xinxiang Key Laboratory of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China.

Dongxian Li (D)

Department of Pathogenic Biology, Xinxiang Key Laboratory of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China.

Rui Zhang (R)

Department of Pathogenic Biology, Xinxiang Key Laboratory of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China.

Xianghuan Xie (X)

Department of Pathogenic Biology, Xinxiang Key Laboratory of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China.

Lihua Guo (L)

Xinxiang Maternity and Child Healthcare Hospital, Xinxiang, Henan 453003, China.

Lixia Hao (L)

Xinxiang Maternity and Child Healthcare Hospital, Xinxiang, Henan 453003, China. Electronic address: haolixia12345@126.com.

Xiaowei Tian (X)

Department of Pathogenic Biology, Xinxiang Key Laboratory of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China.

Zhenke Yang (Z)

Department of Pathogenic Biology, Xinxiang Key Laboratory of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China.

Shuai Wang (S)

Department of Pathogenic Biology, Xinxiang Key Laboratory of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China.

Xuefang Mei (X)

Department of Pathogenic Biology, Xinxiang Key Laboratory of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan 453003, China. Electronic address: xuefangmei123@163.com.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Fécondité › A systematic review of the correlation between...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A systematic review of the correlation between...
questionsmedicales.fr › Maladies urogénitales › Maladies génitales › Infertilité › A systematic review of the correlation between...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › A systematic review of the correlation between...
questionsmedicales.fr › Liquides et sécrétions biologiques › Sécrétions corporelles › Sperme › A systematic review of the correlation between...
questionsmedicales.fr › Infection › Maladies parasitaires › Protozooses › Trichomonase › A systematic review of the correlation between...
questionsmedicales.fr › Eucaryotes › Parabasalidea › Trichomonadida › Trichomonas › Trichomonas vaginalis › A systematic review of the correlation between...