Geriatric Syndromes in Older Adults Hospitalized with COVID-19 in Montreal, Canada.

COVID-19 clinical research geriatric syndromes older adults outcomes

Journal

Canadian geriatrics journal : CGJ
ISSN: 1925-8348
Titre abrégé: Can Geriatr J
Pays: Canada
ID NLM: 101579189

Informations de publication

Date de publication:
Sep 2022
Historique:
entrez: 19 9 2022
pubmed: 20 9 2022
medline: 20 9 2022
Statut: epublish

Résumé

Older adults are more vulnerable to severe infection and mortality due to COVID-19. They have atypical presentations of the disease without respiratory symptoms, making early diagnosis clinically challenging. We aimed to compare the baseline characteristics, presentation, and disease course of older (≥70 yrs & ≥90 yrs) and younger (<70 yrs) patients hospitalized with COVID-19. Retrospective review of 429 consecutive patients hospitalized at two tertiary care hospitals in Montreal, Canada, with PCR-confirmed COVID-19. Baseline characteristics, presentation, in-hospital complications, and outcomes were recorded. Desegregation by age was performed to compare older versus younger individuals. Additional subgroup analyses were performed amongst patients ≥70 stratifying by sex, living situation, and those presenting with geriatric syndromes compared to those without. Patients ≥70 (n=260) presented less frequently with respiratory symptoms compared to patients <70 (n=169) (52% vs. 32%). 11% of patients ≥70 and 24% of patients ≥90 presented with a geriatric syndrome as their sole symptom compared to 3% of those <70. Older adults were more likely to develop disease complications (including delirium, acute kidney injury, and hypernatremia) and had higher in-hospital mortality (32% vs. 13%). Subgroup analyses revealed heightened vulnerability to complications in older men, those from long-term care, and those with at least one geriatric syndrome upon presentation. Older adults presenting to hospital with COVID-19 often have no respiratory symptoms and can present with only a geriatric syndrome. New geriatric syndromes in older individuals should trigger evaluation for COVID-19 and consideration for early initiation of multidisciplinary care to prevent complications.

Sections du résumé

Background UNASSIGNED
Older adults are more vulnerable to severe infection and mortality due to COVID-19. They have atypical presentations of the disease without respiratory symptoms, making early diagnosis clinically challenging. We aimed to compare the baseline characteristics, presentation, and disease course of older (≥70 yrs & ≥90 yrs) and younger (<70 yrs) patients hospitalized with COVID-19.
Methods UNASSIGNED
Retrospective review of 429 consecutive patients hospitalized at two tertiary care hospitals in Montreal, Canada, with PCR-confirmed COVID-19. Baseline characteristics, presentation, in-hospital complications, and outcomes were recorded. Desegregation by age was performed to compare older versus younger individuals. Additional subgroup analyses were performed amongst patients ≥70 stratifying by sex, living situation, and those presenting with geriatric syndromes compared to those without.
Results UNASSIGNED
Patients ≥70 (n=260) presented less frequently with respiratory symptoms compared to patients <70 (n=169) (52% vs. 32%). 11% of patients ≥70 and 24% of patients ≥90 presented with a geriatric syndrome as their sole symptom compared to 3% of those <70. Older adults were more likely to develop disease complications (including delirium, acute kidney injury, and hypernatremia) and had higher in-hospital mortality (32% vs. 13%). Subgroup analyses revealed heightened vulnerability to complications in older men, those from long-term care, and those with at least one geriatric syndrome upon presentation.
Conclusions UNASSIGNED
Older adults presenting to hospital with COVID-19 often have no respiratory symptoms and can present with only a geriatric syndrome. New geriatric syndromes in older individuals should trigger evaluation for COVID-19 and consideration for early initiation of multidisciplinary care to prevent complications.

Identifiants

pubmed: 36117745
doi: 10.5770/cgj.25.579
pii: cgj-25-269
pmc: PMC9427183
doi:

Types de publication

Journal Article

Langues

eng

Pagination

269-278

Informations de copyright

© 2022 Author(s). Published by the Canadian Geriatrics Society.

Déclaration de conflit d'intérêts

CONFLICT OF INTEREST DISCLOSURES We have read and understood the Canadian Geriatrics Journal’s policy on conflicts of interest disclosure and declare no conflict of interest for this paper.

Références

J Am Geriatr Soc. 2020 Dec;68(12):2735-2743
pubmed: 33045106
J Gerontol A Biol Sci Med Sci. 2021 Feb 25;76(3):e4-e12
pubmed: 32845301
JAMA. 2020 Apr 28;323(16):1574-1581
pubmed: 32250385
Clin Infect Dis. 2021 Feb 1;72(3):490-494
pubmed: 32556328
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Ir J Med Sci. 2021 May;190(2):469-474
pubmed: 32959219
Aging Med (Milton). 2020 Sep 17;3(4):237-244
pubmed: 33392429
J Am Geriatr Soc. 1981 Apr;29(4):177-80
pubmed: 7204813
PLoS Med. 2020 Sep 10;17(9):e1003321
pubmed: 32911500
JAMA. 1995 Nov 15;274(19):1552-6
pubmed: 7474224
Mayo Clin Proc Innov Qual Outcomes. 2020 Jun 05;4(3):259-265
pubmed: 32542217
J Am Geriatr Soc. 2020 Nov;68(11):2440-2446
pubmed: 32835425
Biol Sex Differ. 2020 May 25;11(1):29
pubmed: 32450906
J Am Med Dir Assoc. 2021 Mar;22(3):511-513.e3
pubmed: 33503441
Mech Ageing Dev. 2020 Jun;188:111255
pubmed: 32353398
BMC Med. 2020 Jun 25;18(1):194
pubmed: 32586323
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Clin Interv Aging. 2021 Jun 25;16:1223-1230
pubmed: 34234422
JAMA. 2017 Sep 26;318(12):1161-1174
pubmed: 28973626
J Immunol. 2017 Mar 1;198(5):1782-1790
pubmed: 28223406
J Am Geriatr Soc. 2014 Feb;62(2):342-6
pubmed: 24521366
J Infect. 2020 Jun;80(6):656-665
pubmed: 32283155
Age Ageing. 2021 Jan 8;50(1):40-48
pubmed: 32986799
J Intern Med. 2020 Oct;288(4):469-476
pubmed: 32498135
Neurosci Biobehav Rev. 2000 Aug;24(6):627-38
pubmed: 10940438
Front Endocrinol (Lausanne). 2020 Nov 30;11:599255
pubmed: 33329400
JAMA Netw Open. 2020 Nov 2;3(11):e2029540
pubmed: 33211114
JAMA. 2020 May 12;323(18):1775-1776
pubmed: 32203977
N Engl J Med. 2020 May 28;382(22):2081-2090
pubmed: 32329971
J Am Geriatr Soc. 2007 May;55(5):780-91
pubmed: 17493201

Auteurs

Sandrine Couture (S)

Department of Medicine, McGill University Health Centre, Montréal, QC.

Marc-Antoine Lepage (MA)

Department of Medicine, McGill University Health Centre, Montréal, QC.

Claire Godard-Sebillotte (C)

Department of Family Medicine, McGill University, Montréal, QC.

Nadia Sourial (N)

Département de médecine de famille et de médecine d'urgence, Université de Montréal, Montréal, QC.
Centre de recherche du Centre hospitalier de l'Université de Montréal, Montreal, QC.

Catherine Talbot-Hamon (C)

Division of Geriatric Medicine, McGill University Health Centre, Montréal, QC.

Richard Kremer (R)

Division of Medical Biochemistry, McGill University Health Centre, Montréal, QC.

Ami Grunbaum (A)

Division of Medical Biochemistry, McGill University Health Centre, Montréal, QC.

Classifications MeSH