Systems pharmacology dissection of action mechanisms for herbs in osteoporosis treatment.
asperosaponin VI
betulinic acid
calycosin
drug discovery
hederagenin
luteolin
osteoporosis
systems pharmacology
traditional Chinese medicine
Journal
Chinese herbal medicines
ISSN: 2589-3610
Titre abrégé: Chin Herb Med
Pays: Singapore
ID NLM: 101556727
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
21
09
2020
revised:
12
11
2020
accepted:
30
11
2020
entrez:
19
9
2022
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
Osteoporosis has become the biggest cause of non-fatal health issue. Currently, the limitations of traditional anti-osteoporosis drugs such as long-term ill-effects and drug resistance, have raised concerns toward complementary and alternative therapies, particularly herbal medicines and their natural active compounds. Thus, this study aimed to provide an integrative analysis of active chemicals, drug targets and interacting pathways of the herbs for osteoporosis treatment. Here, we introduced a systematic pharmacology model, combining the absorption, distribution, metabolism, and excretion (ADME) screening model, drug targeting and network pharmacology, to probe into the therapeutic mechanisms of herbs in osteoporosis. We obtained 86 natural compounds with favorable pharmacokinetic profiles and their 58 targets from seven osteoporosis-related herbs. Network analysis revealed that they probably synergistically work through multiple mechanisms, such as suppressing inflammatory response, maintaining bone metabolism or improving organism immunity, to benefit patients with osteoporosis. Furthermore, experimental results showed that all the five compounds (calycosin, asperosaponin VI, hederagenin, betulinic acid and luteolin) enhanced osteoblast proliferation and differentiation Herbs and their natural compounds, being characterized as the classical combination therapies, might be engaged in multiple mechanisms to coordinately improve the osteoporosis symptoms. This work may contribute to offer novel strategies and clues for the therapy and drug discovery of osteoporosis and other complex diseases.
Identifiants
pubmed: 36118922
doi: 10.1016/j.chmed.2021.06.001
pii: S1674-6384(21)00071-X
pmc: PMC9476722
doi:
Types de publication
Journal Article
Langues
eng
Pagination
313-331Informations de copyright
© 2021 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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