GREENER Pharmaceuticals for More Sustainable Healthcare.
Journal
Environmental science & technology letters
ISSN: 2328-8930
Titre abrégé: Environ Sci Technol Lett
Pays: United States
ID NLM: 101628367
Informations de publication
Date de publication:
13 Sep 2022
13 Sep 2022
Historique:
received:
01
07
2022
revised:
11
08
2022
accepted:
11
08
2022
entrez:
19
9
2022
pubmed:
20
9
2022
medline:
20
9
2022
Statut:
ppublish
Résumé
Medicines are essential to human health but can also impact the aquatic and terrestrial environment after use by patients and release via excreta into wastewater. We highlight the need for a GREENER approach to identify and meet important environmental criteria, which will help reduce the impact of medicinal residues on the environment. These criteria include effect reduction by avoiding nontarget effects or undesirable moieties, exposure reduction via lower emissions or environmental (bio)degradability, no PBT (persistent, bioaccumulative, and toxic) substances, and risk mitigation. With all of these criteria, however, patient health is of primary importance as medicines are required to be safe and efficacious for treating diseases. We discuss the feasibility of including these criteria for green by design active pharmaceutical ingredients in the process of drug discovery and development and which tools or assays are needed to accomplish this. The integrated GREENER approach can be used to accelerate discussions about future innovations in drug discovery and development.
Identifiants
pubmed: 36118957
doi: 10.1021/acs.estlett.2c00446
pmc: PMC9476650
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
699-705Informations de copyright
© 2022 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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