Increased serum level of alpha-2 macroglobulin and its production by B-lymphocytes in chronic lymphocytic leukemia.
B-lymphocytes
alpha-2-macroglobulin (A2M)
chronic lymphocytic leukemia
classical pathway of complement
complement system
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
12
06
2022
accepted:
08
08
2022
entrez:
19
9
2022
pubmed:
20
9
2022
medline:
21
9
2022
Statut:
epublish
Résumé
Chronic lymphocytic leukemia (CLL), the most common adult's leukemia in the western world, is caused in 95% of the cases by uncontrolled proliferation of monoclonal B-lymphocytes. The complement system in CLL is chronically activated at a low level
Identifiants
pubmed: 36119042
doi: 10.3389/fimmu.2022.953644
pmc: PMC9478581
doi:
Substances chimiques
Immunoglobulin G
0
Pregnancy-Associated alpha 2-Macroglobulins
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
953644Informations de copyright
Copyright © 2022 Michelis, Milhem, Galouk, Stemer, Aviv, Tadmor, Shehadeh, Shvidel, Barhoum and Braester.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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