A Val
Brain imaging
Lower extremity
Neurogenetics
Neuroplasticity
Sensorimotor
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
09
09
2021
revised:
21
06
2022
accepted:
31
08
2022
entrez:
19
9
2022
pubmed:
20
9
2022
medline:
20
9
2022
Statut:
epublish
Résumé
The brain-derived neurotrophic factor (BDNF) protein plays a prominent role in the capacity for neuroplastic change. However, a single nucleotide polymorphism at codon 66 of the The primary objective of this study was to use magnetoencephalography (MEG) to probe if and Procedures: Twenty individuals with CP and eighteen neurotypical controls participated. Standardized low resolution brain electromagnetic tomography (sLORETA) was used to image the somatosensory cortical activity evoked by stimulation of the tibial nerve. The somatosensory cortical activity was weaker in individuals with CP compared to healthy controls (P = 0.04). The individuals with a Val66Met or Met66Met These results convey that Previous literature has extensively documented altered sensorimotor cortical activity in individuals with CP, which ultimately contributes to the clinical deficits in sensorimotor processing documented in this population. While some individuals with CP see vast improvements in their sensorimotor functioning following therapeutic intervention, others are clear non-responders. The underlying basis for this discrepancy is not well understood. Our study is the first to identify that a polymorphism at the gene that codes for brain derived neurotrophic factor (BDNF), a protein well-known to be involved in the capacity for neuroplastic change, may influence the altered sensorimotor cortical activity within this population. Potentially, individuals with CP that have a polymorphism at the
Sections du résumé
Background
UNASSIGNED
The brain-derived neurotrophic factor (BDNF) protein plays a prominent role in the capacity for neuroplastic change. However, a single nucleotide polymorphism at codon 66 of the
Aims
UNASSIGNED
The primary objective of this study was to use magnetoencephalography (MEG) to probe if
Methods and procedures
UNASSIGNED
and Procedures: Twenty individuals with CP and eighteen neurotypical controls participated. Standardized low resolution brain electromagnetic tomography (sLORETA) was used to image the somatosensory cortical activity evoked by stimulation of the tibial nerve.
Outcomes and results
UNASSIGNED
The somatosensory cortical activity was weaker in individuals with CP compared to healthy controls (P = 0.04). The individuals with a Val66Met or Met66Met
Conclusions and implications
UNASSIGNED
These results convey that
What this paper adds
UNASSIGNED
Previous literature has extensively documented altered sensorimotor cortical activity in individuals with CP, which ultimately contributes to the clinical deficits in sensorimotor processing documented in this population. While some individuals with CP see vast improvements in their sensorimotor functioning following therapeutic intervention, others are clear non-responders. The underlying basis for this discrepancy is not well understood. Our study is the first to identify that a polymorphism at the gene that codes for brain derived neurotrophic factor (BDNF), a protein well-known to be involved in the capacity for neuroplastic change, may influence the altered sensorimotor cortical activity within this population. Potentially, individuals with CP that have a polymorphism at the
Identifiants
pubmed: 36119851
doi: 10.1016/j.heliyon.2022.e10545
pii: S2405-8440(22)01833-3
pmc: PMC9474307
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10545Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM144641
Pays : United States
Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Cereb Cortex. 2010 May;20(5):1254-62
pubmed: 19745020
Exp Brain Res. 2006 Jun;172(2):151-62
pubmed: 16538378
J Neurophysiol. 2014 Feb;111(3):573-9
pubmed: 24225536
Neurorehabil Neural Repair. 2017 Mar;31(3):250-260
pubmed: 27856938
Mol Neurobiol. 2022 Aug;59(8):4926-4952
pubmed: 35657457
Hum Brain Mapp. 2016 Oct;37(10):3588-603
pubmed: 27259165
J Physiol. 2021 Feb;599(4):1281-1289
pubmed: 33296078
Rinsho Byori. 1999 Jan;47(1):76-82
pubmed: 10067369
Dev Med Child Neurol. 2005 Aug;47(8):571-6
pubmed: 16108461
Brain Res. 2004 Nov 26;1028(1):92-104
pubmed: 15518646
Dev Med Child Neurol. 2007 Feb;49(2):144-51
pubmed: 17254004
Dev Med Child Neurol. 2008 Oct;50(10):744-50
pubmed: 18834387
Neuroradiology. 2010 Aug;52(8):759-65
pubmed: 20405112
Prog Clin Biol Res. 1994;390:45-56
pubmed: 7724649
JAMA. 2006 Oct 4;296(13):1602-8
pubmed: 17018805
Pediatr Neurol. 2011 Mar;44(3):177-82
pubmed: 21310332
Pediatrics. 2012 Nov;130(5):e1285-312
pubmed: 23045562
Brain Dev. 2012 Aug;34(7):576-83
pubmed: 22018901
Neuroimage. 2020 May 1;211:116610
pubmed: 32044438
Res Dev Disabil. 2011 Mar-Apr;32(2):462-9
pubmed: 21273041
Nat Neurosci. 2006 Jun;9(6):735-7
pubmed: 16680163
J Exp Psychol Learn Mem Cogn. 1992 Sep;18(5):1058-73
pubmed: 1402710
Phys Occup Ther Pediatr. 2003;23(1):43-62
pubmed: 12703384
Cereb Cortex. 2022 Mar 4;32(6):1286-1294
pubmed: 34416763
Cereb Cortex. 2018 Jul 1;28(7):2431-2438
pubmed: 28591842
Dev Med Child Neurol. 2013 Oct;55(10):941-51
pubmed: 23937719
Eur J Neurosci. 2009 Aug;30(3):439-48
pubmed: 19686433
Dev Med Child Neurol Suppl. 2007 Feb;109:8-14
pubmed: 17370477
J Child Neurol. 2007 Mar;22(3):289-93
pubmed: 17621498
Dev Med Child Neurol. 1999 Mar;41(3):166-75
pubmed: 10210249
Dev Med Child Neurol. 2013 Oct;55(10):885-910
pubmed: 23962350
Arch Phys Med Rehabil. 2002 Nov;83(11):1592-6
pubmed: 12422331
Dev Med Child Neurol. 2010 Sep;52(9):811-6
pubmed: 20132142
Res Dev Disabil. 2010 Nov-Dec;31(6):1313-22
pubmed: 20691568
J Child Neurol. 1995 Jul;10(4):300-9
pubmed: 7594266
J Child Neurol. 2012 Oct;27(10):1276-83
pubmed: 22378658
Brain Res Rev. 2008 Nov;59(1):201-20
pubmed: 18708092
Neuroscience. 2015 Oct 1;305:67-75
pubmed: 26235434
Brain Sci. 2022 Mar 24;12(4):
pubmed: 35447966
Front Hum Neurosci. 2014 Sep 12;8:725
pubmed: 25309398
J Neurophysiol. 2015 May 1;113(9):3143-50
pubmed: 25717160
J Psychiatr Res. 2022 Jul;151:676-682
pubmed: 35667336
J Neurosci Methods. 2007 Aug 15;164(1):177-90
pubmed: 17517438
Dev Med Child Neurol. 2014 Mar;56(3):252-8
pubmed: 24341408
Clin Biomech (Bristol, Avon). 2010 Jan;25(1):88-94
pubmed: 19836868
Brain Res Mol Brain Res. 2002 Jun 15;102(1-2):110-2
pubmed: 12191500
J Neurol Phys Ther. 2015 Jan;39(1):33-42
pubmed: 25415551
Dev Med Child Neurol. 2014 Jan;56(1):59-65
pubmed: 24117446
J Child Neurol. 2009 Sep;24(9):1200-4
pubmed: 19525491
Dev Med Child Neurol. 2008 Nov;50(11):832-8
pubmed: 18811710
Trends Neurosci. 2002 Jun;25(6):295-301
pubmed: 12086747
Trends Neurosci. 2000 Dec;23(12):639-45
pubmed: 11137155
Methods Find Exp Clin Pharmacol. 2002;24 Suppl D:5-12
pubmed: 12575463
Dev Med Child Neurol. 2009 Sep;51(9):697-704
pubmed: 19416315
Neurochem Res. 2003 Nov;28(11):1757-69
pubmed: 14584829
Neurosci Lett. 2011 Feb 18;490(1):1-5
pubmed: 21184811
Neuroimage Clin. 2017 Oct 19;17:198-212
pubmed: 29159037
Arch Phys Med Rehabil. 2012 Apr;93(4):696-702
pubmed: 22360974
EBioMedicine. 2018 Feb;28:162-167
pubmed: 29339100
Dev Med Child Neurol. 2013 Dec;55(12):1121-8
pubmed: 23899048
Pediatr Phys Ther. 2000 Winter;12(4):195-6
pubmed: 17091032
Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):122-3
pubmed: 15048661
Dev Med Child Neurol. 2008 Dec;50(12):898-903
pubmed: 18811703