Dentin Matrix Metalloproteinases: A Futuristic Approach Toward Dentin Repair and Regeneration.

dentin matrix metalloproteinases dentin regeneration dentin repair growth factors mmps signalling molecules

Journal

Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737

Informations de publication

Date de publication:
Aug 2022
Historique:
received: 31 07 2022
accepted: 12 08 2022
entrez: 19 9 2022
pubmed: 20 9 2022
medline: 20 9 2022
Statut: epublish

Résumé

Matrix metalloproteinases (MMPs) have been linked to modulating healing during the production of tertiary dentin, as well as the liberation of physiologically active molecules and the control of developmental processes. Although efforts to protect dentin have mostly centered on preventing these proteases from doing their jobs, their role is actually much more intricate and crucial for dentin healing than anticipated. The role of MMPs as bioactive dentin matrix components involved in dentin production, repair, and regeneration is examined in the current review. The mechanical characteristics of dentin, especially those of reparative and reactionary dentin, and the established functions of MMPs in dentin production are given particular attention. Because they are essential parts of the dentin matrix, MMPs should be regarded as leading applicants for dentin regeneration.

Identifiants

pubmed: 36120221
doi: 10.7759/cureus.27946
pmc: PMC9464706
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

e27946

Informations de copyright

Copyright © 2022, Agrawal et al.

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

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Auteurs

Paridhi Agrawal (P)

Department of Conservative Dentistry and Endodontics, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences University, Wardha, IND.

Pradnya Nikhade (P)

Department of Conservative Dentistry and Endodontics, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences University, Wardha, IND.

Manoj Chandak (M)

Department of Conservative Dentistry and Endodontics, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences University, Wardha, IND.

Anuja Ikhar (A)

Department of Conservative Dentistry and Endodontics, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences University, Wardha, IND.

Rushikesh Bhonde (R)

Department of Conservative Dentistry and Endodontics, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences University, Wardha, IND.

Classifications MeSH