Primary neuroendocrine tumors of the breast: About a case and of the review of the literature.
Anatomopathology
Breast tumor
Case report
Large cell neuroendocrine carcinoma
Treatment
Journal
International journal of surgery case reports
ISSN: 2210-2612
Titre abrégé: Int J Surg Case Rep
Pays: Netherlands
ID NLM: 101529872
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
20
06
2022
revised:
08
09
2022
accepted:
09
09
2022
pubmed:
20
9
2022
medline:
20
9
2022
entrez:
19
9
2022
Statut:
ppublish
Résumé
primary neuroendocrine carcinomas of the breast represent a minority and are currently included in the latest WHO classification of breast tumors. Their morphological and immunohistochemical features (chromogranin and synaptophysin expression) allow the retain the diagnosis. we report a case of primary neuroendocrine carcinoma of the breast in 50 years old Moroccan women who presented nodule 4,2 cm palpable and mobile of the left breast. Lumpectomy axillary lymph node resection was performed. a histopathological examination disclosed the diagnosis of primary breast neuroendocrine tumors with negative surgical margins and positive lymph nodes (13 N+/19 N). The tumor cells were positive for neuroendocrine markers, a highKi67 proliferation index and the membrane expression of the invasive tumor cells to the anti-HER2 antibody was 2, a FISH done which was equivocal. Our patient received 6 courses of chemotherapythen radiotherapy; currently she received adjuvant hormonal treatment with Tamoxifene.
Identifiants
pubmed: 36122420
pii: S2210-2612(22)00888-4
doi: 10.1016/j.ijscr.2022.107642
pmc: PMC9568780
pii:
doi:
Types de publication
Case Reports
Langues
eng
Pagination
107642Informations de copyright
Copyright © 2022. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare having no conflicts of interest for this article.
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