A song for the unsung: The relevance of Plasmodium vinckei as a laboratory rodent malaria system.
In vivo model
Plasmodium vinckei
Rodent malaria parasites
Journal
Parasitology international
ISSN: 1873-0329
Titre abrégé: Parasitol Int
Pays: Netherlands
ID NLM: 9708549
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
20
07
2022
revised:
02
09
2022
accepted:
12
09
2022
pubmed:
20
9
2022
medline:
23
11
2022
entrez:
19
9
2022
Statut:
ppublish
Résumé
Rodent malaria parasites (RMPs) allow the study of malaria parasite biology across its entire life cycle through a vertebrate host and a mosquito vector under laboratory conditions. Among the four RMPs originally collected from wild thicket rats in sub-Saharan Central Africa and adapted to laboratory mice, Plasmodium vinckei has the largest geographical range and includes the largest number of sub-species, demonstrating its deep genetic diversity. Despite affording the same advantages as other RMP species and additionally displaying a large degree of phenotypic and genotypic diversity, P. vinckei has seen limited use in the laboratory. Here, we review the contribution of P. vinckei to our understanding of malaria and highlight the areas where it could offer an advantage over other RMP species in future studies.
Identifiants
pubmed: 36122687
pii: S1383-5769(22)00144-1
doi: 10.1016/j.parint.2022.102680
pii:
doi:
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102680Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.