Prospective observational comparison of arteria uterina blood flow between two frozen embryo transfer cycle regimens: natural cycle versus hormonal replacement cycle.
Aa. uterinae
Frozen embryo transfer
Hormonal replacement cycle
Natural cycle
Preeclampsia
Pulsatility index
Journal
Archives of gynecology and obstetrics
ISSN: 1432-0711
Titre abrégé: Arch Gynecol Obstet
Pays: Germany
ID NLM: 8710213
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
26
05
2022
accepted:
07
09
2022
pubmed:
20
9
2022
medline:
8
11
2022
entrez:
19
9
2022
Statut:
ppublish
Résumé
Is there a difference in the blood flow of the Arteria uterina in frozen embryo transfer (FET) cycles between a Natural Cycle (NC) and a Hormonal Replacement Therapy (HRT) cycle? Prospective observational study with measurement of the pulsatility index (PI) and resistance index (RI) throughout the ovarian stimulation cycle for IVF/ICSI, the FET cycle and at 12 weeks of gestation. A total of 124 ovarian stimulation cycles with preimplantation genetic testing for aneuploidy (PGT-A) and "freeze-all" strategy due to PGT-A were included. Mean patient's age was 31.4 years, mean BMI 26.47 kg/m2, mean AMH 3.62 ng/ml and a mean AFC of 13. FET cycles were performed in 77 patients (NC protocol: 37.7%, HRT protocol: 62.2%). The overall pregnancy rate was 75%, (NC group: 79%, HRT-group 73%; not significant). No significant change of PI and RI was seen during hormonal stimulation. In FET cycles, there was a significant increase between cycle day 2/3 and ovulation/P4-start in the HRT-cycle, followed by a significant decrease until 12 weeks of gestation. The slope of the decrease in patients with a pregnancy in an HRT-approach was a bit steeper than in the NC-approach for both PI and RI, however, without a significant difference. Early measurements of the blood flow parameters during the FET cycle do not reveal a difference between the NC- and the HRT-approach for FET, which could be predictive for development of pre-eclampsia.
Identifiants
pubmed: 36123426
doi: 10.1007/s00404-022-06789-6
pii: 10.1007/s00404-022-06789-6
doi:
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2177-2185Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Farrer-Brown G, Beilby JOW, Tarbit MH (1970) The blood supply of the uterus. 1. Arterial Vasculature. BJOG Int J Obstet Gynaecol. 77:673–81
doi: 10.1111/j.1471-0528.1970.tb03592.x
Bolla D, In-Albon S, Papadia A, Di Naro E, Gasparri ML, Mueller MM et al (2015) Doppler ultrasound flow evaluation of the uterine arteries significantly correlates with tumor size in cervical cancer patients. Ann Surg Oncol 22(Suppl 3):S959-963
doi: 10.1245/s10434-015-4655-4
pubmed: 26036189
Flam F, Almström H, Hellström AC, Moberger B (1995) Value of uterine artery Doppler in endometrial cancer. Acta Oncol 34:779–782
doi: 10.3109/02841869509127186
pubmed: 7576745
Kanelopoulos N, Dendrinos S, Oikonomou A, Panagopoulos P, Markussis V (2003) Doppler-ultrasound as a predictor of uterine fibroid response to GnRH therapy. Int J Gynaecol Obstet 82:41–47
doi: 10.1016/S0020-7292(03)00127-9
pubmed: 12834940
Polat P, Suma S, Kantarcý M, Alper F, Levent A (2002) Color Doppler US in the evaluation of uterine vascular abnormalities. Radiographics 22:47–53
doi: 10.1148/radiographics.22.1.g02ja0947
pubmed: 11796897
Cnossen JS, Morris RK, ter Riet G, Mol BWJ, van der Post JAM, Coomarasamy A et al (2008) Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis. Can Med Assoc J 178:701–711
doi: 10.1503/cmaj.070430
Tan MY, Syngelaki A, Poon LC, Rolnik DL, O’Gorman N, Delgado JL et al (2018) Screening for pre-eclampsia by maternal factors and biomarkers at 11–13 weeks’ gestation. Ultrasound Obstet Gynecol 52:186–195
doi: 10.1002/uog.19112
pubmed: 29896812
Adakan S, Yoldemir T, Tavmergen E, Goker E, Killi R (2005) Predictivity of uterine artery, arcuate artery, and intraovarian artery Doppler indices measured on the day of human chorionic gonadotropin injection on pregnancy outcomes. Fertil Steril 84:529–532
doi: 10.1016/j.fertnstert.2005.02.021
pubmed: 16084903
Aytoz A, Ubaldi F, Tournaye H, Nagy ZP, Van Steirteghem A, Devroey P (1997) The predictive value of uterine artery blood flow measurements for uterine receptivity in an intracytoplasmic sperm injection program. Fertil Steril 68:935–937
doi: 10.1016/S0015-0282(97)00333-6
pubmed: 9389829
Guo J, Chaemsaithong P, Huang J, Chung JPW, Huang J, Poon LCY et al (2021) Comparison of uterine artery Doppler measurements at 6 weeks of pregnancy after IVF between pregnancies that resulted in miscarriage and ongoing pregnancies. Int J Gynaecol Obstet 152:249–255
doi: 10.1002/ijgo.13371
pubmed: 32920837
Hoozemans DA, Schats R, Lambalk NB, Homburg R, Hompes PGA (2008) Serial uterine artery Doppler velocity parameters and human uterine receptivity in IVF/ICSI cycles. Ultrasound Obstet Gynecol 31:432–438
doi: 10.1002/uog.5179
pubmed: 18241087
Timur H, Çinar M, Hançerlioğullari N, Alkan M, İnal HA, Uygur D et al (2017) Associations between first-trimester uterine artery Doppler velocimetry indices and adverse perinatal outcomes in women conceiving via in vitro fertilization. J Matern-Fetal Neonatal Med 30:684–688
doi: 10.1080/14767058.2016.1182979
pubmed: 27123869
Fertility treatment 2019: trends and figures. Human fertilisation and embryology authority. https://www.hfea.gov.uk/about-us/publications/research-and-data/fertility-treatment-2019-trends-and-figures/#Section4 . Accessed 22 Sept 2021
Groenewoud ER, Cantineau AEP, Kollen BJ, Macklon NS, Cohlen BJ (2013) What is the optimal means of preparing the endometrium in frozen–thawed embryo transfer cycles? A systematic review and meta-analysis. Hum Reprod Update 19:458–470
doi: 10.1093/humupd/dmt030
pubmed: 23820515
Ghobara T, Gelbaya TA, Ayeleke RO (2017) Cycle regimens for frozen-thawed embryo transfer. Cochrane Database Syst Rev 7:3414
Jing S, Li XF, Zhang S, Gong F, Lu G, Lin G (2019) Increased pregnancy complications following frozen-thawed embryo transfer during an artificial cycle. J Assist Reprod Genet 36:925–933
doi: 10.1007/s10815-019-01420-1
pubmed: 30924053
pmcid: 6541721
GinströmErnstad E, Wennerholm U-B, Khatibi A, Petzold M, Bergh C (2019) Neonatal and maternal outcome after frozen embryo transfer: increased risks in programmed cycles. Am J Obstet Gynecol 221:126.e1-126.e18
doi: 10.1016/j.ajog.2019.03.010
von Versen-Höynck F, Schaub AM, Chi Y-Y, Chiu K-H, Liu J, Lingis M et al (1979) Increased preeclampsia risk and reduced aortic compliance with in vitro fertilization cycles in the absence of a corpus luteum. Hypertension 2019(73):640–649
Bowyer L, Brown MA, Jones M (2003) Forearm blood flow in pre-eclampsia. BJOG 110:383–391
doi: 10.1046/j.1471-0528.2003.02030.x
pubmed: 12699800
La Marca A, Sunkara SK (2014) Individualization of controlled ovarian stimulation in IVF using ovarian reserve markers: from theory to practice. Hum Reprod Update 20:124–140
doi: 10.1093/humupd/dmt037
pubmed: 24077980
Fatemi HM, Kyrou D, Bourgain C, Van den Abbeel E, Griesinger G, Devroey P (2010) Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin-induced natural cycle. Fertil Steril 94:2054–2058
doi: 10.1016/j.fertnstert.2009.11.036
pubmed: 20097333
Irani M, Robles A, Gunnala V, Reichman D, Rosenwaks Z (2017) Optimal parameters for determining the LH surge in natural cycle frozen-thawed embryo transfers. J Ovarian Res 10:70
doi: 10.1186/s13048-017-0367-7
pubmed: 29037231
pmcid: 5644145
Sibai BM, Hauth J, Caritis S, Lindheimer MD, MacPherson C, Klebanoff M et al (2000) Hypertensive disorders in twin versus singleton gestations. Am J Obstet Gynecol 182:938–942
doi: 10.1016/S0002-9378(00)70350-4
pubmed: 10764477
Li C, He Y-C, Xu J-J, Wang Y, Liu H, Duan C-C et al (2021) Perinatal outcomes of neonates born from different endometrial preparation protocols after frozen embryo transfer: a retrospective cohort study. BMC Pregnancy Childbirth 21:341
doi: 10.1186/s12884-021-03791-9
pubmed: 33926401
pmcid: 8086106
Engmann L, Sladkevicius P, Agrawal R, Bekir J, Campbell S, Tan SL (1999) The pattern of changes in ovarian stromal and uterine artery blood flow velocities during in vitro fertilization treatment and its relationship with outcome of the cycle. Ultrasound Obstet Gynecol 13:26–33
doi: 10.1046/j.1469-0705.1999.13010026.x
pubmed: 10201083
Cacciatore B, Simberg N, Fusaro P, Tiitinen A (1996) Transvaginal Doppler study of uterine artery blood flow in in vitro fertilization-embryo transfer cycles. Fertil Steril 66:130–134
doi: 10.1016/S0015-0282(16)58400-3
pubmed: 8752624
Gómez O, Figueras F, Fernández S, Bennasar M, Martínez JM, Puerto B et al (2008) Reference ranges for uterine artery mean pulsatility index at 11–41 weeks of gestation. Ultrasound Obstet Gynecol 32:128–132
doi: 10.1002/uog.5315
pubmed: 18457355
Mäkikallio K, Tekay A, Jouppila P (2004) Uteroplacental hemodynamics during early human pregnancy: a longitudinal study. Gynecol Obstet Invest 58:49–54
doi: 10.1159/000077914
pubmed: 15087597
Khalil A, Garcia-Mandujano R, Maiz N, Elkhouli M, Elkhaouli M, Nicolaides KH (2014) Longitudinal changes in uterine artery Doppler and blood pressure and risk of pre-eclampsia. Ultrasound Obstet Gynecol 43:541–547
doi: 10.1002/uog.13257
pubmed: 24265180
van Duijn L, Rousian M, Reijnders IF, Willemsen SP, Baart EB, Laven JSE et al (2021) The influence of frozen-thawed and fresh embryo transfer on utero-placental (vascular) development: the Rotterdam Periconception cohort. Hum Reprod 36:2091–2100
doi: 10.1093/humrep/deab070
pubmed: 33974704
pmcid: 8289318
Pereira MM, Mainigi M, Strauss JF (2021) Secretory products of the corpus luteum and preeclampsia. Hum Reprod Update. https://doi.org/10.1093/humupd/dmab003
doi: 10.1093/humupd/dmab003
pubmed: 33748839
pmcid: 8222764