First report on Vitamin B
5MTHF
Biorefinery
Nutraceuticals
Scheffersomyces stipitis
THF
Journal
Biotechnology for biofuels and bioproducts
ISSN: 2731-3654
Titre abrégé: Biotechnol Biofuels Bioprod
Pays: England
ID NLM: 9918300888906676
Informations de publication
Date de publication:
19 Sep 2022
19 Sep 2022
Historique:
received:
29
06
2022
accepted:
26
08
2022
entrez:
19
9
2022
pubmed:
20
9
2022
medline:
20
9
2022
Statut:
epublish
Résumé
The demand for naturally derived products is continuously growing. Nutraceuticals such as pre- and post-biotics, antioxidants and vitamins are prominent examples in this scenario, but many of them are mainly produced by chemical synthesis. The global folate market is expected to register a CAGR of 5.3% from 2019 to 2024 and reach USD 1.02 billion by the end of 2024. Vitamin B Glucose and xylose are the main sugars released during the pretreatment and hydrolysis processes of several residual lignocellulosic biomasses (such as corn stover, wheat straw or bagasse). We optimized the growth conditions in minimal medium formulated with these sugars and investigated the key role of oxygenation and nitrogen source on folate production. Vitamin B For the first time, the non-Saccharomyces yeast S. stipitis was used to produce folate. The results confirm its potential as a microbial cell factory for folate production, which can be also improved both by genetic engineering strategies and by fine-tuning the fermentation conditions and nutrient requirements.
Sections du résumé
BACKGROUND
BACKGROUND
The demand for naturally derived products is continuously growing. Nutraceuticals such as pre- and post-biotics, antioxidants and vitamins are prominent examples in this scenario, but many of them are mainly produced by chemical synthesis. The global folate market is expected to register a CAGR of 5.3% from 2019 to 2024 and reach USD 1.02 billion by the end of 2024. Vitamin B
RESULTS
RESULTS
Glucose and xylose are the main sugars released during the pretreatment and hydrolysis processes of several residual lignocellulosic biomasses (such as corn stover, wheat straw or bagasse). We optimized the growth conditions in minimal medium formulated with these sugars and investigated the key role of oxygenation and nitrogen source on folate production. Vitamin B
CONCLUSIONS
CONCLUSIONS
For the first time, the non-Saccharomyces yeast S. stipitis was used to produce folate. The results confirm its potential as a microbial cell factory for folate production, which can be also improved both by genetic engineering strategies and by fine-tuning the fermentation conditions and nutrient requirements.
Identifiants
pubmed: 36123695
doi: 10.1186/s13068-022-02194-y
pii: 10.1186/s13068-022-02194-y
pmc: PMC9487109
doi:
Types de publication
Journal Article
Langues
eng
Pagination
98Subventions
Organisme : Accordo di collaborazione Regione Lombardia-ENEA
ID : Dgr 7792/2018
Organisme : Accordo di collaborazione Regione Lombardia-ENEA
ID : Dgr 7792/2018
Organisme : Food Social Sensor Network
ID : FOODNET, 2016 - NAZ - 0143/A
Organisme : Food Social Sensor Network
ID : FOODNET, 2016 - NAZ - 0143/A
Informations de copyright
© 2022. The Author(s).
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