Delayed reorganisation of F-actin cytoskeleton and reversible chromatin condensation in scleral fibroblasts under simulated pathological strain.
Chromatin condensation parameter
Cytoskeleton
Fibroblasts
Glaucoma
Nucleus
Sclera
Tensile strain
Journal
Biochemistry and biophysics reports
ISSN: 2405-5808
Titre abrégé: Biochem Biophys Rep
Pays: Netherlands
ID NLM: 101660999
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
22
07
2022
revised:
25
08
2022
accepted:
27
08
2022
entrez:
20
9
2022
pubmed:
21
9
2022
medline:
21
9
2022
Statut:
epublish
Résumé
Mechanical loading regulates the functional capabilities of the ocular system, particularly in the sclera ('white of the eye') - the principal load-bearing tissue of the ocular globe. Resident fibroblasts of the scleral eye wall are continuously subjected to fluctuating mechanical strains arising from eye movements, cerebrospinal fluid pressure and, most influentially, intra-ocular pressure (IOP). Whilst fibroblasts are hypothesised to actively participate in scleral biomechanics, to date limited information has been reported on how the macroscopic stresses and strains are transmitted via their cytoskeletal networks. In this study, the effect of applying either a '
Identifiants
pubmed: 36123992
doi: 10.1016/j.bbrep.2022.101338
pii: S2405-5808(22)00138-8
pmc: PMC9482111
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101338Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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