Evaluation of Diagnostic Accuracy of Alpha-Fodrin Antibody in Iranian Patients with Sjogren's Disease.
Alpha-fodrin
Sjogren's syndrome
biomarkers
diagnosis
Journal
Advanced biomedical research
ISSN: 2277-9175
Titre abrégé: Adv Biomed Res
Pays: India
ID NLM: 101586897
Informations de publication
Date de publication:
2022
2022
Historique:
received:
18
10
2020
revised:
11
04
2021
accepted:
12
06
2021
entrez:
20
9
2022
pubmed:
21
9
2022
medline:
21
9
2022
Statut:
epublish
Résumé
Sjogren's syndrome, as a chronic autoimmune disease, involves in lymphocytic infiltration in the exocrine glands. As the result of exocrine glands disruption, the clinical hallmark of this disease including dryness of mouth and eyes along with fatigue and joint pain occur. However, heterogeneity of clinical presentations among newly diagnosed adult patients with Sjogren's syndrome leads to difficulty in its diagnosis. One of the diagnostic criteria for Sjogren's syndrome is the presence of autoantibodies in patient serum. One of the novel biomarkers suggested for diagnosis of Sjogren is alpha-fodrin antibody. In this study, we aimed to evaluate the diagnostic power of anti-α-fodrin antibody among the Iranian population for the first time. We recruited 82 individuals in this study. Alpha-fodrin were measured in case and control with Elisa kit as 16.71 (9.84) and 18.44 (11.54). There was no any significant difference between two groups regarding alpha-fodrin level ( Alpha-fodrin test did not have acceptable predictive power for predicting Sjogren's disease; however, it could be associated with disease progression.
Sections du résumé
Background
UNASSIGNED
Sjogren's syndrome, as a chronic autoimmune disease, involves in lymphocytic infiltration in the exocrine glands. As the result of exocrine glands disruption, the clinical hallmark of this disease including dryness of mouth and eyes along with fatigue and joint pain occur. However, heterogeneity of clinical presentations among newly diagnosed adult patients with Sjogren's syndrome leads to difficulty in its diagnosis. One of the diagnostic criteria for Sjogren's syndrome is the presence of autoantibodies in patient serum. One of the novel biomarkers suggested for diagnosis of Sjogren is alpha-fodrin antibody. In this study, we aimed to evaluate the diagnostic power of anti-α-fodrin antibody among the Iranian population for the first time.
Materials and Methods
UNASSIGNED
We recruited 82 individuals in this study. Alpha-fodrin were measured in case and control with Elisa kit as 16.71 (9.84) and 18.44 (11.54).
Results
UNASSIGNED
There was no any significant difference between two groups regarding alpha-fodrin level (
Conclusions
UNASSIGNED
Alpha-fodrin test did not have acceptable predictive power for predicting Sjogren's disease; however, it could be associated with disease progression.
Identifiants
pubmed: 36124018
doi: 10.4103/abr.abr_260_20
pii: ABR-11-64
pmc: PMC9482376
doi:
Types de publication
Journal Article
Langues
eng
Pagination
64Informations de copyright
Copyright: © 2022 Advanced Biomedical Research.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Arthritis Care Res (Hoboken). 2012 Apr;64(4):475-87
pubmed: 22563590
Clin Exp Rheumatol. 2001 Jul-Aug;19(4):411-5
pubmed: 11491496
Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11024-9
pubmed: 26286991
Zhonghua Nei Ke Za Zhi. 2008 May;47(5):366-8
pubmed: 18953942
Clin Biochem. 2013 Oct;46(15):1372-6
pubmed: 23639676
Clin Immunol. 2017 Sep;182:48-54
pubmed: 28428095
Ann Rheum Dis. 2015 Nov;74(11):1983-9
pubmed: 24938285
Rheumatology (Oxford). 2015 Feb;54(2):219-30
pubmed: 25342375
Rheumatology (Oxford). 2009 Sep;48(9):1077-82
pubmed: 19553376
Science. 1997 Apr 25;276(5312):604-7
pubmed: 9110981
J Rheumatol. 1999 Mar;26(3):604-8
pubmed: 10090170
J Rheumatol. 2004 Nov;31(11):2310-1; author reply 2311
pubmed: 15517652
Arch Dermatol. 1999 May;135(5):535-9
pubmed: 10328193
Expert Opin Biol Ther. 2007 Jan;7(1):31-40
pubmed: 17150017
Medicine (Baltimore). 2017 Dec;96(50):e8542
pubmed: 29390256
Ann Rheum Dis. 2017 Jan;76(1):9-16
pubmed: 27789466
N Engl J Med. 2018 Mar 08;378(10):931-939
pubmed: 29514034
Nat Rev Dis Primers. 2016 Jul 07;2:16047
pubmed: 27383445
Ann Rheum Dis. 2012 Feb;71(2):295-301
pubmed: 21979002
Rheumatology (Oxford). 2012 Dec;51 Suppl 6:vi5-9
pubmed: 23221588
J Rheumatol. 2004 Mar;31(3):504-7
pubmed: 14994395