DNA replication timing: Biochemical mechanisms and biological significance.
DNA replication origin
DNA replication timing
MCM
ORC
Origin activation
S-phase regulation
Stochastic model
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
31
08
2022
received:
16
05
2022
accepted:
02
09
2022
pubmed:
21
9
2022
medline:
26
10
2022
entrez:
20
9
2022
Statut:
ppublish
Résumé
The regulation of DNA replication is a fascinating biological problem both from a mechanistic angle-How is replication timing regulated?-and from an evolutionary one-Why is replication timing regulated? Recent work has provided significant insight into the first question. Detailed biochemical understanding of the mechanism and regulation of replication initiation has made possible robust hypotheses for how replication timing is regulated. Moreover, technical progress, including high-throughput, single-molecule mapping of replication initiation and single-cell assays of replication timing, has allowed for direct testing of these hypotheses in mammalian cells. This work has consolidated the conclusion that differential replication timing is a consequence of the varying probability of replication origin initiation. The second question is more difficult to directly address experimentally. Nonetheless, plausible hypotheses can be made and one-that replication timing contributes to the regulation of chromatin structure-has received new experimental support.
Identifiants
pubmed: 36125226
doi: 10.1002/bies.202200097
pmc: PMC9783711
mid: NIHMS1855121
doi:
Substances chimiques
Chromatin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200097Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM134300
Pays : United States
Informations de copyright
© 2022 Wiley Periodicals LLC.
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