Dual Monoclonal Antibodies on Sars-Cov-2 Alpha and Delta Variants: Clinical and Virological Efficacy.

Humans SARS-CoV-2 / genetics Spike Glycoprotein, Coronavirus Antibodies, Monoclonal / therapeutic use Neutralization Tests Antibodies, Viral Antiviral Agents / therapeutic use Antibodies, Neutralizing COVID-19 Drug Treatment
Bamlanivimab/Etesevimab COVID-19 Casirivimab/Imdevimab SARS-CoV-2 monoclonal antibodies mutation selection

Journal

Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614

Informations de publication

Date de publication:
26 10 2022
Historique:
pubmed: 21 9 2022
medline: 29 10 2022
entrez: 20 9 2022
Statut: ppublish

Résumé

Monoclonal antibodies (MAbs) targeting the Spike glycoprotein of SARS-CoV-2 is a key strategy to prevent severe COVID-19. Here, the efficacy of two monoclonal antibody bitherapies against SARS-CoV-2 was assessed on 92 patients at high risk of severe COVID-19 between March and October 2021 (Bichat-Claude Bernard Hospital, Paris, France). Nine patients died despite appropriate management. From 14 days following treatment initiation, we observed a slower viral load decay for patients treated with the bitherapy Bamlanivimab/Etsevimab compared to the Casirivimab/Imdevimab association therapy (

Identifiants

DOI: 10.1128/spectrum.02152-22 PMID: 36125289 PMC: PMC9603708
pubmed: 36125289
doi: 10.1128/spectrum.02152-22
pmc: PMC9603708
doi:

Substances chimiques

imdevimab 2Z3DQD2JHM
casirivimab J0FI6WE1QN
bamlanivimab 45I6OFJ8QH
Spike Glycoprotein, Coronavirus 0
Antibodies, Monoclonal 0
Antibodies, Viral 0
Antiviral Agents 0
Antibodies, Neutralizing 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0215222

Références

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pubmed: 34260849

Auteurs

Valentine Marie Ferré (VM)

Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, Paris, France.
Virology Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France.
ORCID: 0000-0002-2196-6141

Nathan Peiffer-Smadja (N)

Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, Paris, France.
Infectious Disease Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France.

Laura Kramer (L)

Pharmacy Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France.

Romain Coppée (R)

Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, Paris, France.
ORCID: 0000-0002-3024-5928

Aïcha Kante (A)

Infectious Disease Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France.

Margaux Debarge (M)

Pharmacy Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France.

Christophe Choquet (C)

Emergency Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France.

Thibault Saint Joannis (T)

Virology Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France.

Donia Bouzid (D)

Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, Paris, France.
Emergency Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France.
ORCID: 0000-0002-7538-3320

Jonathan Messika (J)

Université Paris Cité and Université Sorbonne Paris Nord, INSERM U1152 PHERE, Paris, France.
Pneumology Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France.
Paris Transplant Group, Paris, France.

Jennifer Le Grand (J)

Pharmacy Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France.

Michael Thy (M)

Infectious Disease Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France.
Université Paris Cité and Université Sorbonne Paris Nord, EA 7323-Pharmacology and Therapeutic Evaluation in Children and Pregnant Women, Paris, France.

Solen Kernéis (S)

Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, Paris, France.
Equipe de Prévention du Risque Infectieux (EPRI), AP-HP, Hôpital Bichat, Paris, France.

Diane Descamps (D)

Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, Paris, France.
Virology Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France.

Benoit Visseaux (B)

Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, Paris, France.
Virology Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France.
ORCID: 0000-0002-9279-5538

Jade Ghosn (J)

Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, Paris, France.
Infectious Disease Department, AP-HP, Bichat-Claude Bernard Hospital, Paris, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dual Monoclonal Antibodies on Sars-Cov-2 Alpha...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Dual Monoclonal Antibodies on Sars-Cov-2 Alpha...
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