Translating Animal Models of Ischemic Stroke to the Human Condition.
Animal model
Cerebrovascular
Neuroprotection
Preclinical testing
Stroke
Therapy
Journal
Translational stroke research
ISSN: 1868-601X
Titre abrégé: Transl Stroke Res
Pays: United States
ID NLM: 101517297
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
20
07
2022
accepted:
12
09
2022
revised:
30
08
2022
medline:
13
11
2023
pubmed:
21
9
2022
entrez:
20
9
2022
Statut:
ppublish
Résumé
Ischemic stroke is a leading cause of death and disability. However, very few neuroprotective agents have shown promise for treatment of ischemic stroke in clinical trials, despite showing efficacy in many successful preclinical studies. This may be attributed, at least in part, to the incongruency between experimental animal stroke models used in preclinical studies and the manifestation of ischemic stroke in humans. Most often the human population selected for clinical trials are more diverse than the experimental model used in a preclinical study. For successful translation, it is critical to develop clinical trial designs that match the experimental animal model used in the preclinical study. This review aims to provide a comprehensive summary of commonly used animal models with clear correlates between rodent models used to study ischemic stroke and the clinical stroke pathologies with which they most closely align. By improving the correlation between preclinical studies and clinical trials, new neuroprotective agents and stroke therapies may be more accurately and efficiently identified.
Identifiants
pubmed: 36125734
doi: 10.1007/s12975-022-01082-9
pii: 10.1007/s12975-022-01082-9
doi:
Substances chimiques
Neuroprotective Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
842-853Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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