A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-β2 signaling.

Actins Animals Cell Line, Tumor Down-Regulation Mice Transforming Growth Factor beta2 Zebrafish
CP: Cancer TGFβ2 dormancy extravasation intravital imaging invadopodia lattice light-sheet microscopy metastasis quiescence srGAP1 zebrafish

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
20 09 2022
Historique:
received: 12 07 2021
revised: 06 05 2022
accepted: 24 08 2022
entrez: 21 9 2022
pubmed: 22 9 2022
medline: 24 9 2022
Statut: ppublish

Résumé

Many breast cancer (BC) patients suffer from complications of metastatic disease. To form metastases, cancer cells must become migratory and coordinate both invasive and proliferative programs at distant organs. Here, we identify srGAP1 as a regulator of a proliferative-to-invasive switch in BC cells. High-resolution light-sheet microscopy demonstrates that BC cells can form actin-rich protrusions during extravasation. srGAP1

Identifiants

DOI: 10.1016/j.celrep.2022.111358 PMID: 36130489 PMC: PMC9596226
pubmed: 36130489
pii: S2211-1247(22)01190-1
doi: 10.1016/j.celrep.2022.111358
pmc: PMC9596226
mid: NIHMS1837778
pii:
doi:

Substances chimiques

Actins 0
Transforming Growth Factor beta2 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111358

Subventions

Organisme : NCI NIH HHS
ID : R01 CA244780
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM108569
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA060553
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA196521
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA078207
Pays : United States
Organisme : NCI NIH HHS
ID : K22 CA196750
Pays : United States
Organisme : NIH HHS
ID : S10 OD025194
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR026639
Pays : United States

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests A.N. receives research support for work unrelated to this study from Boehringer-Ingelheim. D.Q.M. is a paid consultant for Arcadia Science.

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Auteurs

Chandrani Mondal (C)

Department of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Majo J Gacha-Garay (MJ)

Biochemistry and Cell Biology Department, Stony Brook University, Stony Brook, NY 11794, USA.

Kathryn A Larkin (KA)

Biochemistry and Cell Biology Department, Stony Brook University, Stony Brook, NY 11794, USA.

Rebecca C Adikes (RC)

Biochemistry and Cell Biology Department, Stony Brook University, Stony Brook, NY 11794, USA.

Julie S Di Martino (JS)

Department of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Chen-Chi Chien (CC)

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Madison Fraser (M)

Department of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Ireti Eni-Aganga (I)

Department of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Esperanza Agullo-Pascual (E)

Microscopy and Advanced Bioimaging Core, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Katarzyna Cialowicz (K)

Microscopy and Advanced Bioimaging Core, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Umut Ozbek (U)

Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Alexandra Naba (A)

Department of Physiology & Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA; University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA.

Angelo Gaitas (A)

Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Tian-Ming Fu (TM)

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.

Srigokul Upadhyayula (S)

Department of Molecular and Cellular Biology, UC Berkeley, CA 94720, USA.

Eric Betzig (E)

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA; Department of Molecular and Cellular Biology, UC Berkeley, CA 94720, USA.

David Q Matus (DQ)

Biochemistry and Cell Biology Department, Stony Brook University, Stony Brook, NY 11794, USA.

Benjamin L Martin (BL)

Biochemistry and Cell Biology Department, Stony Brook University, Stony Brook, NY 11794, USA.

Jose Javier Bravo-Cordero (JJ)

Department of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: josejavier.bravo-cordero@mssm.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Actines › A proliferative to invasive switch is mediated...
questionsmedicales.fr › Eucaryotes › Animaux › A proliferative to invasive switch is mediated...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › A proliferative to invasive switch is mediated...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation négative › A proliferative to invasive switch is mediated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A proliferative to invasive switch is mediated...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Facteur de croissance transformant bêta-2 › A proliferative to invasive switch is mediated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › A proliferative to invasive switch is mediated...