External validation of a prediction model for estimating fat mass in children and adolescents in 19 countries: individual participant data meta-analysis.

To evaluate the performance of a UK based prediction model for estimating fat-free mass (and indirectly fat mass) in children and adolescents in non-UK settings. Individual participant data meta-analysis. 19 countries. 5693 children and adolescents (49.7% boys) aged 4 to 15 years with complete data on the predictors included in the UK based model (weight, height, age, sex, and ethnicity) and on the independently assessed outcome measure (fat-free mass determined by deuterium dilution assessment). The outcome of the UK based prediction model was natural log transformed fat-free mass (lnFFM). Predictive performance statistics of R The model showed good predictive ability in non-UK populations of children and adolescents, providing R The UK based prediction model, which is based on readily available measures, provides predictions of childhood fat-free mass, and hence fat mass, in a range of non-UK settings that explain a large proportion of the variability in observed fat-free mass, and exhibit good calibration performance, especially after recalibration of the intercept for each population. The model demonstrates good generalisability in both low-middle income and high income populations of healthy children and adolescents aged 4-15 years.

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Competing interests: All authors have completed the ICMJE uniform disclosure form and declare: this research was supported by grants from the British Heart Foundation, the Wellcome Trust, and the National Institute for Health and Care Research Applied Research Collaboration South London; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work.