A cellular hierarchy in melanoma uncouples growth and metastasis.

Animals Cell Communication Cell Differentiation Cell Lineage Cell Proliferation Cell Tracking Cellular Reprogramming Endothelial Cells Melanoma / genetics Mesoderm / pathology Mice Neoplasm Metastasis / pathology Neural Crest / embryology Phenotype Single-Cell Analysis Transcriptome Tumor Microenvironment

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
10 2022
Historique:
received: 01 07 2020
accepted: 17 08 2022
pubmed: 22 9 2022
medline: 12 10 2022
entrez: 21 9 2022
Statut: ppublish

Résumé

Although melanoma is notorious for its high degree of heterogeneity and plasticity

Identifiants

DOI: 10.1038/s41586-022-05242-7 PMID: 36131018 PMC: PMC10439739
pubmed: 36131018
doi: 10.1038/s41586-022-05242-7
pii: 10.1038/s41586-022-05242-7
pmc: PMC10439739
mid: NIHMS1922523
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

190-198

Subventions

Organisme : Medical Research Council
ID : MC_PC_17230
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK056645
Pays : United States
Organisme : Wellcome Trust
ID : 219478/Z/19/Z
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom

Commentaires et corrections

Type : ErratumIn
Type : CommentIn

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Panagiotis Karras (P)

Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Department of Oncology, KU Leuven, Leuven, Belgium.

Ignacio Bordeu (I)

Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK.
The Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, UK.
Departamento de Física, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Santiago, Chile.

Joanna Pozniak (J)

Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Department of Oncology, KU Leuven, Leuven, Belgium.

Ada Nowosad (A)

Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Department of Oncology, KU Leuven, Leuven, Belgium.

Cecilia Pazzi (C)

Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Department of Oncology, KU Leuven, Leuven, Belgium.
ORCID: 0000-0001-5172-3215

Nina Van Raemdonck (N)

Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Department of Oncology, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-8913-6275

Ewout Landeloos (E)

Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Department of Oncology, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-9128-6432

Yannick Van Herck (Y)

Department of General Medical Oncology, UZ Leuven, Leuven, Belgium.

Dennis Pedri (D)

Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Department of Oncology, KU Leuven, Leuven, Belgium.
ORCID: 0000-0001-6619-0132

Greet Bervoets (G)

Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Department of Oncology, KU Leuven, Leuven, Belgium.

Samira Makhzami (S)

Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Department of Oncology, KU Leuven, Leuven, Belgium.

Jia Hui Khoo (JH)

BGI-Shenzhen, Shenzhen, China.
ORCID: 0000-0001-8385-5669

Benjamin Pavie (B)

VIB BioImaging Core, VIB Center for Brain and Disease Research, Leuven, Belgium.
VIB Bioimaging Core, VIB Center for Inflammation Research, Ghent, Belgium.
Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
ORCID: 0000-0002-0249-3844

Jochen Lamote (J)

FACS Expertise Center, Center for Cancer Biology, VIB, Leuven, Belgium.

Oskar Marin-Bejar (O)

Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Department of Oncology, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-6889-6566

Michael Dewaele (M)

Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium.
Department of Oncology, KU Leuven, Leuven, Belgium.

Han Liang (H)

BGI-Shenzhen, Shenzhen, China.

Xingju Zhang (X)

BGI-Shenzhen, Shenzhen, China.

Yichao Hua (Y)

Department of Oncology, KU Leuven, Leuven, Belgium.
Laboratory of Tumor Microenvironment and Therapeutic Resistance, Center for Cancer Biology, VIB, Leuven, Belgium.
ORCID: 0000-0002-1695-172X

Jasper Wouters (J)

Center for Brain & Disease Research, VIB-KU Leuven, Leuven, Belgium.
Department of Human Genetics, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-7129-2990

Robin Browaeys (R)

Data Mining and Modeling for Biomedicine Group, VIB Center for Inflammation Research, Ghent, Belgium.
Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium.

Gabriele Bergers (G)

Department of Oncology, KU Leuven, Leuven, Belgium.
Laboratory of Tumor Microenvironment and Therapeutic Resistance, Center for Cancer Biology, VIB, Leuven, Belgium.

Yvan Saeys (Y)

Data Mining and Modeling for Biomedicine Group, VIB Center for Inflammation Research, Ghent, Belgium.
Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium.
ORCID: 0000-0002-0415-1506

Francesca Bosisio (F)

Laboratory for Translational Cell and Tissue Research, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-8874-2003

Joost van den Oord (J)

Laboratory for Translational Cell and Tissue Research, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.

Diether Lambrechts (D)

Laboratory of Translational Genetics, Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Translational Genetics, Center for Human Genetics, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-3429-302X

Anil K Rustgi (AK)

Herbert Irving Comprehensive Center, Columbia University Irving Medical Center, New York, USA.

Oliver Bechter (O)

Department of General Medical Oncology, UZ Leuven, Leuven, Belgium.
ORCID: 0000-0003-0667-3284

Cedric Blanpain (C)

Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.
ORCID: 0000-0002-4028-4322

Benjamin D Simons (BD)

Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK.
The Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, UK.
Wellcome Trust-MRC Stem Cell Institute, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-3875-7071

Florian Rambow (F)

Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium. florian.rambow@kuleuven.vib.be.
Department of Oncology, KU Leuven, Leuven, Belgium. florian.rambow@kuleuven.vib.be.
Department of Applied Computational Cancer Research, Institute for AI in Medicine (IKIM), University Hospital Essen, Essen, Germany. florian.rambow@kuleuven.vib.be.
University Duisburg-Essen, Essen, Germany. florian.rambow@kuleuven.vib.be.
German Cancer Consortium (DKTK), partner site Essen, Essen, Germany. florian.rambow@kuleuven.vib.be.

Jean-Christophe Marine (JC)

Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium. jeanchristophe.marine@kuleuven.vib.be.
Department of Oncology, KU Leuven, Leuven, Belgium. jeanchristophe.marine@kuleuven.vib.be.
ORCID: 0000-0003-2433-9837

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Communication cellulaire › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Lignage cellulaire › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Suivi cellulaire › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › Phénomènes génétiques › Reprogrammation cellulaire › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › Structures de l'embryon › Feuillets embryonnaires › Mésoderme › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › Structures de l'embryon › Crête neurale › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › A cellular hierarchy in melanoma uncouples...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › A cellular hierarchy in melanoma uncouples...