Uptake, distribution and radio-enhancement effects of gold nanoparticles in tumor microtissues.
Journal
Nanoscale advances
ISSN: 2516-0230
Titre abrégé: Nanoscale Adv
Pays: England
ID NLM: 101738708
Informations de publication
Date de publication:
14 Jul 2020
14 Jul 2020
Historique:
received:
01
04
2020
accepted:
28
05
2020
entrez:
22
9
2022
pubmed:
2
6
2020
medline:
2
6
2020
Statut:
epublish
Résumé
Radiotherapy is an integral and highly effective part of cancer therapy, applicable in over 50% of patients affected by cancer. Due to the low specificity of the X-ray irradiation, the maximal radiation dose is greatly limited in order to avoid damage to surrounding healthy tissue. The limitations in applicable dose oftentimes result in the survival of a subpopulation of radio-resistant cells that then cause cancer reoccurence. Approaches based on tumor-targeted high atomic number inorganic nanoparticles have been proposed to locally increase the photoelectric absorption cross-section of tumors relative to healthy tissue. However, the complex interplay between the nanoparticle radio-enhancers and the tumor tissue has led to poor translation of
Identifiants
pubmed: 36132396
doi: 10.1039/d0na00256a
pii: d0na00256a
pmc: PMC9417636
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2992-3001Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There are no conflicts to declare.
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