Electroacupuncture reduces chronic itch
Acupuncture
CB1 receptors
GABA
PAG
chronic itch
glutamate
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
04
2022
accepted:
05
07
2022
entrez:
22
9
2022
pubmed:
23
9
2022
medline:
23
9
2022
Statut:
epublish
Résumé
Chronic itch severely reduces the quality of life of patients. Electroacupuncture (EA) is widely used to treat chronic itch. However, the underlying mechanism of this therapeutic action of EA is largely unknown. Cannabinoid CB1 receptors in the ventrolateral periaqueductal gray (vlPAG) mediate the analgesic effect of EA. Using a dry skin-induced itch model in mice, we determined whether EA treatment reduces chronic itch via CB1 receptors in the vlPAG. We showed that the optimal inhibitory effect of EA on chronic itch was achieved at the high frequency and high intensity (100 Hz and 3 mA) at "Quchi" (LI11) and "Hegu" (LI14) acupoints, which are located in the same spinal dermatome as the cervical skin lesions. EA reversed the increased expression of CB1 receptors in the vlPAG and decreased the concentration of 5-hydroxytryptamine (5-HT) in the medulla oblongata and the expression of gastrin-releasing peptide receptors (GRPR) in the cervical spinal cord. Furthermore, knockout of CB1 receptors on GABAergic neurons in the vlPAG attenuated scratching behavior and the 5-HT concentration in the medulla oblongata. In contrast, knockout of CB1 receptors on glutamatergic neurons in the vlPAG blocked the antipruritic effects of EA and the inhibitory effect of EA on the 5-HT concentration in the medulla oblongata. Our findings suggest that EA treatment reduces chronic itch by activation of CB1 receptors on glutamatergic neurons and inhibition of CB1 receptors on GABAergic neurons in the vlPAG, thereby inhibiting the 5-HT release from the medulla oblongata to GRPR-expressing neurons in the spinal cord. Our findings suggest that EA attenuates chronic itch
Identifiants
pubmed: 36133809
doi: 10.3389/fphar.2022.931600
pii: 931600
pmc: PMC9483028
doi:
Types de publication
Journal Article
Langues
eng
Pagination
931600Informations de copyright
Copyright © 2022 Ge, Zhan-Mu, Chen, Zhang, Wang, Liu, Li, Lan, Li, Sun, Shi, Dou, Pan, Li, Jing and Li.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Pain. 2015 Jul;156(7):1240-1246
pubmed: 25830923
Neural Regen Res. 2018 Sep;13(9):1594-1601
pubmed: 30127120
Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10720-E10729
pubmed: 30348772
Evid Based Complement Alternat Med. 2019 Jul 29;2019:4706865
pubmed: 31467575
J Neural Transm (Vienna). 2000;107(8-9):931-45
pubmed: 11041273
Zhongguo Zhen Jiu. 2020 Jul 12;40(7):765-70
pubmed: 32648402
J Appl Physiol (1985). 2009 Jun;106(6):1800-9
pubmed: 19359606
Nat Commun. 2019 Sep 25;10(1):4356
pubmed: 31554789
Nephron. 1987;47(3):179-83
pubmed: 3500424
Res Vet Sci. 2008 Apr;84(2):159-65
pubmed: 17559895
J Appl Physiol (1985). 2009 Jun;106(6):1793-9
pubmed: 19325030
Front Neurosci. 2021 Feb 16;15:625471
pubmed: 33664646
Neuropharmacology. 2016 Jun;105:577-586
pubmed: 26907809
Psychopharmacology (Berl). 2011 Aug;216(3):323-31
pubmed: 21340468
Neuroscience. 2013 Oct 10;250:697-714
pubmed: 23891755
J Invest Dermatol. 2012 Jul;132(7):1886-91
pubmed: 22418875
Nature. 2007 Aug 9;448(7154):700-3
pubmed: 17653196
Nat Neurosci. 2018 Jun;21(6):894
pubmed: 29674654
Vet Dermatol. 2011 Apr;22(2):121-31
pubmed: 21251097
J Dermatol Sci. 2014 Apr;74(1):23-30
pubmed: 24418195
Neural Regen Res. 2018 Aug;13(8):1390-1395
pubmed: 30106051
Front Neurosci. 2019 May 17;13:484
pubmed: 31156369
Zhen Ci Yan Jiu. 2020 Apr 25;45(4):299-304
pubmed: 32333535
Lancet. 2003 Feb 22;361(9358):690-4
pubmed: 12606187
Nat Rev Neurosci. 2014 Jan;15(1):19-31
pubmed: 24356071
Physiol Rev. 2003 Jul;83(3):1017-66
pubmed: 12843414
J Pain Symptom Manage. 2010 Jul;40(1):117-25
pubmed: 21796811
J Pharmacol Exp Ther. 2006 Mar;316(3):969-82
pubmed: 16284279
Neuropharmacology. 2012 Sep;63(4):743-9
pubmed: 22683515
J Neural Transm (Vienna). 2015 Mar;122(3):363-7
pubmed: 24915981
Neuron. 2014 Nov 19;84(4):821-34
pubmed: 25453842
Clin Exp Dermatol. 2018 Jul;43(5):553-558
pubmed: 29424035
Neurosci Lett. 2003 Aug 14;347(1):62-4
pubmed: 12865142
Naunyn Schmiedebergs Arch Pharmacol. 1998 Oct;358(4):411-7
pubmed: 9826062
J Pharmacol Exp Ther. 2009 Apr;329(1):314-23
pubmed: 19168707
J Zhejiang Univ Sci B. 2006 Mar;7(3):209-14
pubmed: 16502508
Front Mol Neurosci. 2018 Apr 06;11:112
pubmed: 29681797
Bioorg Med Chem Lett. 2012 Apr 15;22(8):2803-6
pubmed: 22444677
Proc Natl Acad Sci U S A. 2019 Dec 5;:
pubmed: 31806757
Science. 2015 Oct 30;350(6260):550-4
pubmed: 26516282
J Clin Invest. 2020 Dec 1;130(12):6555-6570
pubmed: 32841213
Evid Based Complement Alternat Med. 2010 Jun;7(2):167-8
pubmed: 19204011