Association of Early Beta Human Chorionic Gonadotropin With Ischemic Placental Disease in Singleton Pregnancies After In Vitro Fertilization.
beta human chorionic gonadotropin
in vitro fertilization
ischemic placental disease
placental abruption
preeclampsia
small for gestational age
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
accepted:
17
08
2022
entrez:
22
9
2022
pubmed:
23
9
2022
medline:
23
9
2022
Statut:
epublish
Résumé
To evaluate whether an initial or two-day percent increase in serum beta-human chorionic gonadotropin (βhCG) is associated with ischemic placental disease (IPD) in singleton pregnancies after autologous or donor IVF. This was a secondary analysis of a retrospective cohort study of deliveries linked to IVF cycles at a single academic tertiary hospital and infertility treatment center. We included all patients (≥18 years old) who had a singleton live birth or intrauterine fetal demise (IUFD) resulting from either autologous fresh (n=1,347), autologous frozen (n=454), or donor (n=253) IVF cycles. Main outcome reassures: The primary outcome was a composite outcome of IPD or IUFD due to placental insufficiency. IPDs included preeclampsia, placental abruption, and small for gestational age (SGA). Neither initial βhCG nor two-day percent increases in βhCG were associated with an increased risk of IPD for any type of IVF cycle. Initial and two-day percent increases in βhCG were significantly higher when comparing frozen with fresh IVF and donor with autologous IVF (all P≤0.01). Among singleton autologous and donor IVF cycles, the initial and two-day percent increase in serum βhCG were not associated with IPD or its components. However, significant βhCG differences existed by cycle type and oocyte source.
Identifiants
pubmed: 36134080
doi: 10.7759/cureus.28117
pmc: PMC9481264
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e28117Informations de copyright
Copyright © 2022, Shah et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Gynecol Obstet Invest. 2010;70(2):126-31
pubmed: 20357475
Eur J Obstet Gynecol Reprod Biol. 2011 Nov;159(1):77-82
pubmed: 21839575
J Assist Reprod Genet. 2019 Sep;36(9):1917-1926
pubmed: 31359234
Prenat Diagn. 2011 Feb;31(2):171-5
pubmed: 21268036
Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H1936-44
pubmed: 22427518
Placenta. 2006 Apr-May;27(4-5):483-90
pubmed: 15990167
Fertil Steril. 2011 Mar 1;95(3):959-63
pubmed: 20813359
Obstet Gynecol. 2017 Mar;129(3):465-472
pubmed: 28178056
Prenat Diagn. 2010 Apr;30(4):293-308
pubmed: 20166149
Fertil Steril. 2019 Apr;111(4):714-721
pubmed: 30826115
Gynecol Endocrinol. 2019 Mar;35(3):261-266
pubmed: 30296871
Hum Reprod. 2006 Mar;21(3):823-8
pubmed: 16311298
Placenta. 2015 Aug;36(8):921-5
pubmed: 26138364
Reprod Biomed Online. 2018 Aug;37(2):208-215
pubmed: 29773310
Hum Reprod. 2001 Apr;16(4):691-5
pubmed: 11278220
Obstet Gynecol. 2011 Oct;118(4):863-71
pubmed: 21934450
BMC Pediatr. 2003 Jul 8;3:6
pubmed: 12848901
Fertil Steril. 2014 Jul;102(1):10-8
pubmed: 24890274
Fertil Steril. 2017 Apr;107(4):901-903
pubmed: 28292618
Fertil Steril. 2020 Dec;114(6):1225-1231
pubmed: 33012553
Fertil Steril. 2009 May;91(5):1760-4
pubmed: 18455162
Fertil Steril. 2011 Aug;96(2):505-7
pubmed: 21719003
Semin Reprod Med. 2016 Jan;34(1):27-35
pubmed: 26696276
Fertil Steril. 2010 Feb;93(2):397-404
pubmed: 19249031
Reprod Sci. 2021 Jul;28(7):1827-1838
pubmed: 33034863
Obstet Gynecol. 2004 Jul;104(1):50-5
pubmed: 15229000
Fertil Steril. 2007 Jul;88(1):82-9
pubmed: 17307176
Reprod Biomed Online. 2017 Sep;35(3):272-278
pubmed: 28625759
Semin Perinatol. 2014 Apr;38(3):159-66
pubmed: 24836828
Obstet Gynecol. 2010 Dec;116(6):1387-1392
pubmed: 21099607
Hum Reprod. 2014 Jun;29(6):1153-60
pubmed: 24722241
Fertil Steril. 2016 May;105(5):1208-1214.e3
pubmed: 26812243