Effect of vitamins C and E on cancer survival; a systematic review.
Cancer
Survival
Systematic review
Vitamin C
Vitamin E
Journal
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
ISSN: 2008-2231
Titre abrégé: Daru
Pays: Switzerland
ID NLM: 101125969
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
03
03
2022
accepted:
16
09
2022
pubmed:
23
9
2022
medline:
6
12
2022
entrez:
22
9
2022
Statut:
ppublish
Résumé
Association between vitamins C (VC)/ E (VE) and cancer survival is inconsistent. This systematic review is aimed to summarize trials for effects of VC/VE on cancer survival. Relevant English trials were retrieved from PubMed, Cochrane Library, Embase, Web of Science, Scopus databases, and Clinicaltrials.gov through 21/June/2022. Inclusion criteria were all trials which assessed sole/combinations intake of VC/VE on survival rate, mortality, or remission of any cancer. Exclusion criteria were observational and animal studies. We reached 30 trials conducted on 38,936 patients with various cancers. Due to severe methodological heterogeneity, meta-analysis was impossible. High dose VC + chemotherapy or radiation was safe with an overall survival (OS) 182 days - 21.5 months. Sole oral or intravenous high dose VC was safe with non-significant change in OS (2.9-8.2 months). VE plus chemotherapy was safe, resulted in stabling diseases for 5 years in 70- 86.7% of patients and OS 109 months. It was found 60% and 16% non-significant reductions in adjusted hazard ratio (HR) deaths or recurrence by 200 mg/d tocotrienol + tamoxifen in breast cancer, respectively. Sole intake of 200-3200 mg/d tocotrienol before resectable pancreatic cancer was safe and significantly increased cancer cells' apoptosis. Combination VC and VE was non-significantly reduced 7% in rate of neoplastic gastric polyp. Although our study is supported improvement of survival and progression rates of cancers by VC/VE, more high quality trials with large sample sizes are required to confirm. CRD42020152795.
Identifiants
pubmed: 36136247
doi: 10.1007/s40199-022-00451-x
pii: 10.1007/s40199-022-00451-x
pmc: PMC9715902
doi:
Substances chimiques
Antineoplastic Agents
0
Ascorbic Acid
PQ6CK8PD0R
Tamoxifen
094ZI81Y45
Tocotrienols
0
Vitamins
0
Types de publication
Journal Article
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
427-441Subventions
Organisme : Tehran University of Medical Sciences & health services
ID : 40713-192-03-97
Informations de copyright
© 2022. The Author(s), under exclusive licence to Tehran University of Medical Sciences.
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