SUBSTANTIAL EXTERNAL DOSE RATE VARIABILITY OBSERVED IN A COHORT OF LU-177 PATIENTS INDEPENDENT OF BMI AND SEX.
Journal
Radiation protection dosimetry
ISSN: 1742-3406
Titre abrégé: Radiat Prot Dosimetry
Pays: England
ID NLM: 8109958
Informations de publication
Date de publication:
16 Oct 2022
16 Oct 2022
Historique:
received:
01
11
2021
revised:
06
07
2022
accepted:
23
08
2022
pubmed:
23
9
2022
medline:
19
11
2022
entrez:
22
9
2022
Statut:
ppublish
Résumé
External dose rates were measured 1 m away from 230 Lu-177 patients to characterise the variability in normalised dose rates as a function of administered activity, body mass index (BMI) and sex. The largest dose rate observed was 0.07 mSv/h associated with an administered activity of 7.2 GBq. Substantial variability was found in the distribution of the normalised dose rate associated that had an average of 0.0037 mSv/h per GBq and a 95% confidence interval of 0.0024-0.0058 mSv/h per GBq. Based on this study, estimating the patient dose rate based on the Lu-177 gamma exposure factor overestimates the dose rate by a factor of 2. A statistically significant inverse relationship was found between the patient dose rate and patient BMI and an empirically derived equation relating these two quantities was reported. On average, male patient dose rates were 3.5% lower than female dose rates, which may be attributed to the larger average BMI of the male patient group.
Identifiants
pubmed: 36138119
pii: 6711422
doi: 10.1093/rpd/ncac187
pmc: PMC9667277
doi:
Substances chimiques
Lutetium-177
BRH40Y9V1Q
Lutetium
5H0DOZ21UJ
Radioisotopes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1476-1482Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIH HHS
Pays : United States
Organisme : NCI NIH HHS
ID : P30 Ca008748
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press.
Références
Radiat Prot Dosimetry. 2016 Sep;170(1-4):221-4
pubmed: 26396263
Ann ICRP. 2007;37(2-4):1-332
pubmed: 18082557
Ann Nucl Med. 2018 Apr;32(3):217-235
pubmed: 29333565
EJNMMI Res. 2018 Apr 12;8(1):32
pubmed: 29651569
Med Phys. 2015 Apr;42(4):1851-7
pubmed: 25832075
EJNMMI Phys. 2019 Apr 25;6(1):7
pubmed: 31025215
Health Phys. 2013 Aug;105(2):187-91
pubmed: 23799503
Health Phys. 2000 Jun;78(6):739-43
pubmed: 10832936
Appl Radiat Isot. 2003 Aug-Sep;59(2-3):109-18
pubmed: 12941498
Chem Rev. 1999 Sep 8;99(9):2269-92
pubmed: 11749482
N Engl J Med. 2017 Jan 12;376(2):125-135
pubmed: 28076709
Z Med Phys. 2011 Dec;21(4):266-73
pubmed: 21719263
Ann Nucl Med. 2014 Jul;28(6):531-9
pubmed: 24687907
Cancer Biother Radiopharm. 2012 Nov;27(9):561-9
pubmed: 23078020
Ann ICRP. 2008;38(3):7-96
pubmed: 19285593
Nat Methods. 2020 Mar;17(3):261-272
pubmed: 32015543