Chemigenetic indicators based on synthetic chelators and green fluorescent protein.


Journal

Nature chemical biology
ISSN: 1552-4469
Titre abrégé: Nat Chem Biol
Pays: United States
ID NLM: 101231976

Informations de publication

Date de publication:
01 2023
Historique:
received: 16 12 2021
accepted: 04 08 2022
pubmed: 23 9 2022
medline: 31 12 2022
entrez: 22 9 2022
Statut: ppublish

Résumé

Molecular fluorescent indicators are versatile tools for dynamic imaging of biological systems. We now report a class of indicators that are based on the chemigenetic combination of a synthetic ion-recognition motif and a protein-based fluorophore. Specifically, we have developed a calcium ion (Ca

Identifiants

pubmed: 36138142
doi: 10.1038/s41589-022-01134-z
pii: 10.1038/s41589-022-01134-z
doi:

Substances chimiques

Chelating Agents 0
Green Fluorescent Proteins 147336-22-9
Ligands 0
Calcium SY7Q814VUP
Fluorescent Dyes 0
Sodium 9NEZ333N27

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

38-44

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Wenchao Zhu (W)

Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Shiori Takeuchi (S)

Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Shosei Imai (S)

Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Tohru Terada (T)

Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Takumi Ueda (T)

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Yusuke Nasu (Y)

Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Takuya Terai (T)

Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. terai@chem.s.u-tokyo.ac.jp.

Robert E Campbell (RE)

Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. campbell@chem.s.u-tokyo.ac.jp.
Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada. campbell@chem.s.u-tokyo.ac.jp.

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