Comparison of the Gut Microbiome between Atopic and Healthy Dogs-Preliminary Data.
atopic dermatitis
bacterial composition
bacterial diversity
dog
gut microbiota
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
12 Sep 2022
12 Sep 2022
Historique:
received:
11
07
2022
revised:
31
08
2022
accepted:
09
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
Human studies show that in addition to skin barrier and immune cell dysfunction, both the cutaneous and the gut microbiota can influence the pathogenesis of atopic diseases. There is currently no data on the gut-skin axis in allergic canines. Therefore, the aim of this study was to assess the bacterial diversity and composition of the gut microbiome in dogs with atopic dermatitis (AD). Stool samples from adult beagle dogs (n = 3) with spontaneous AD and a healthy control group (n = 4) were collected at Days 0 and 30. After the first sampling, allergic dogs were orally dosed on a daily basis with oclacitinib for 30 days, and then re-sampled. Sequencing of the V3-V4 region of the 16S rRNA gene was performed on the Illumina MiSeq platform and the data were analyzed using QIIME2. The atopic dogs had a significantly lower gut microbiota alpha-diversity than healthy dogs (
Identifiants
pubmed: 36139237
pii: ani12182377
doi: 10.3390/ani12182377
pmc: PMC9495170
pii:
doi:
Types de publication
Journal Article
Langues
eng
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