Lung Adenocarcinoma Cell Sensitivity to Chemotherapies: A Spotlight on Lipid Droplets and
SREBF1
chemotherapy
lipid droplets
lung adenocarcinoma
neutrophils
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
14 Sep 2022
14 Sep 2022
Historique:
received:
15
07
2022
revised:
02
09
2022
accepted:
09
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
To explore the relationship between cancer cell SREBF1 expression, lipid droplets (LDs) formation, and the sensitivity to chemotherapies, we cultured lung adenocarcinoma cells H1299 (with LD) and H1563 (without LD) in a serum-free basal medium (BM) or neutrophil degranulation products containing medium (NDM), and tested cell responses to cisplatin and etoposide. By using the DESeq2 Bioconductor package, we detected 674 differentially expressed genes (DEGs) associated with NDM/BM differences between two cell lines, many of these genes were associated with the regulation of sterol and cholesterol biosynthesis processes. Specifically,
Identifiants
pubmed: 36139614
pii: cancers14184454
doi: 10.3390/cancers14184454
pmc: PMC9497419
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : German Center for Lung Research
ID : 82DZL002B1
Organisme : German Center for Lung Research
ID : 82DZL00402
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