Inflammation: Roles in Skeletal Muscle Atrophy.
ALP
UPS
inflammation
skeletal muscle atrophy
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
29 Aug 2022
29 Aug 2022
Historique:
received:
22
07
2022
revised:
25
08
2022
accepted:
26
08
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
Various diseases can cause skeletal muscle atrophy, usually accompanied by inflammation, mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced proteolysis. The underlying mechanism of inflammation in skeletal muscle atrophy is extremely complex and has not been fully elucidated, thus hindering the development of effective therapeutic drugs and preventive measures for skeletal muscle atrophy. In this review, we elaborate on protein degradation pathways, including the ubiquitin-proteasome system (UPS), the autophagy-lysosome pathway (ALP), the calpain and caspase pathways, the insulin growth factor 1/Akt protein synthesis pathway, myostatin, and muscle satellite cells, in the process of muscle atrophy. Under an inflammatory environment, various pro-inflammatory cytokines directly act on nuclear factor-κB, p38MAPK, and JAK/STAT pathways through the corresponding receptors, and then are involved in muscle atrophy. Inflammation can also indirectly trigger skeletal muscle atrophy by changing the metabolic state of other tissues or cells. This paper explores the changes in the hypothalamic-pituitary-adrenal axis and fat metabolism under inflammatory conditions as well as their effects on skeletal muscle. Moreover, this paper also reviews various signaling pathways related to muscle atrophy under inflammatory conditions, such as cachexia, sepsis, type 2 diabetes mellitus, obesity, chronic obstructive pulmonary disease, chronic kidney disease, and nerve injury. Finally, this paper summarizes anti-amyotrophic drugs and their therapeutic targets for inflammation in recent years. Overall, inflammation is a key factor causing skeletal muscle atrophy, and anti-inflammation might be an effective strategy for the treatment of skeletal muscle atrophy. Various inflammatory factors and their downstream pathways are considered promising targets for the treatment and prevention of skeletal muscle atrophy.
Identifiants
pubmed: 36139760
pii: antiox11091686
doi: 10.3390/antiox11091686
pmc: PMC9495679
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : National Natural Science Foundation of China
ID : 82072160
Organisme : National Natural Science Foundation of China
ID : 81901933
Références
Biophys Rev. 2021 Mar 4;13(2):203-219
pubmed: 33927785
Am J Respir Cell Mol Biol. 2010 Apr;42(4):461-71
pubmed: 19520920
Adv Exp Med Biol. 2017;960:221-245
pubmed: 28585201
Cell Metab. 2013 Sep 3;18(3):368-79
pubmed: 24011072
Eur Heart J. 2021 Nov 7;42(42):4389-4400
pubmed: 34343257
Cell Metab. 2011 Feb 2;13(2):170-82
pubmed: 21284984
J Clin Invest. 1989 May;83(5):1614-22
pubmed: 2785120
Biomolecules. 2021 Sep 08;11(9):
pubmed: 34572540
J Cachexia Sarcopenia Muscle. 2021 Feb;12(1):70-90
pubmed: 33350058
Clin Respir J. 2018 Mar;12(3):939-947
pubmed: 28054460
J Physiol. 2005 May 15;565(Pt 1):309-23
pubmed: 15774533
Cell Metab. 2016 Nov 8;24(5):672-684
pubmed: 27829137
Cell Prolif. 2022 Mar;55(3):e13181
pubmed: 35088922
Mol Med Rep. 2021 Jul;24(1):
pubmed: 33955507
Antioxidants (Basel). 2021 Jun 24;10(7):
pubmed: 34202494
Adv Exp Med Biol. 2018;1088:267-279
pubmed: 30390256
Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E743-E752
pubmed: 29311302
Mol Cell Biol. 2009 Sep;29(17):4798-811
pubmed: 19546233
Molecules. 2021 Nov 25;26(23):
pubmed: 34885708
Biochem Biophys Res Commun. 2021 Sep 17;570:184-190
pubmed: 34293592
Nat Commun. 2015 Apr 01;6:6693
pubmed: 25827749
Mol Endocrinol. 2014 Mar;28(3):317-30
pubmed: 24438338
Wiley Interdiscip Rev Syst Biol Med. 2020 Jan;12(1):e1462
pubmed: 31407867
Physiol Rev. 2003 Jul;83(3):731-801
pubmed: 12843408
Front Pharmacol. 2019 Sep 10;10:997
pubmed: 31616291
Cell Res. 2014 Jan;24(1):42-57
pubmed: 24343578
Nat Rev Dis Primers. 2017 Oct 05;3:17071
pubmed: 28980624
Int Urol Nephrol. 2020 Aug;52(8):1551-1561
pubmed: 32488756
Oncogene. 2012 Jul 19;31(29):3467-81
pubmed: 22105366
J Thorac Dis. 2018 May;10(5):2752-2759
pubmed: 29997937
PLoS One. 2011;6(9):e23999
pubmed: 21931634
Naunyn Schmiedebergs Arch Pharmacol. 2017 Apr;390(4):423-433
pubmed: 28124088
Mol Med Rep. 2022 Feb;25(2):
pubmed: 34913071
Cell Signal. 2005 Mar;17(3):365-75
pubmed: 15567067
Oxid Med Cell Longev. 2022 Jan 20;2022:5694223
pubmed: 35096269
Compr Physiol. 2015 Jul 1;5(3):1027-59
pubmed: 26140708
Cell Signal. 2008 Apr;20(4):675-83
pubmed: 18222647
Nature. 2006 Dec 14;444(7121):875-80
pubmed: 17167476
Pharmacol Res. 2021 Oct;172:105807
pubmed: 34389456
J Cell Mol Med. 2021 Oct;25(20):9724-9739
pubmed: 34514712
Pharmacol Res. 2020 Aug;158:104871
pubmed: 32413482
J Physiol Sci. 2020 Sep 16;70(1):40
pubmed: 32938372
Science. 2009 Apr 17;324(5925):407-10
pubmed: 19372434
Front Endocrinol (Lausanne). 2022 Jun 30;13:917113
pubmed: 35846289
J Cachexia Sarcopenia Muscle. 2021 Jun;12(3):779-795
pubmed: 33951335
Nat Cell Biol. 2011 Feb;13(2):132-41
pubmed: 21258367
Crit Care Med. 2007 Sep;35(9 Suppl):S602-8
pubmed: 17713416
Ann Transl Med. 2020 Nov;8(22):1524
pubmed: 33313269
J Biol Chem. 2005 Feb 25;280(8):6447-54
pubmed: 15590628
Acta Biochim Biophys Sin (Shanghai). 2005 Nov;37(11):719-27
pubmed: 16270150
Annu Rev Cell Dev Biol. 2004;20:61-86
pubmed: 15473835
FEBS J. 2013 Sep;280(17):4294-314
pubmed: 23517348
Kidney Int. 2019 Mar;95(3):506-517
pubmed: 30598193
Antioxidants (Basel). 2021 Dec 28;11(1):
pubmed: 35052570
Sci Rep. 2018 Jun 13;8(1):9037
pubmed: 29899565
Plast Reconstr Surg. 2019 Mar;143(3):779-788
pubmed: 30817650
Clin Exp Pharmacol Physiol. 2008 Jul;35(7):846-51
pubmed: 18215180
Hum Mol Genet. 2018 Dec 1;27(23):4061-4076
pubmed: 30137324
Nat Cell Biol. 2018 Aug;20(8):917-927
pubmed: 30050118
Antioxid Redox Signal. 2018 Jul 1;29(1):15-36
pubmed: 28895473
J Ethnopharmacol. 2021 Mar 1;267:113470
pubmed: 33068652
Ann Transl Med. 2019 Nov;7(22):680
pubmed: 31930081
Mol Cell. 2016 Nov 3;64(3):467-479
pubmed: 27773676
Muscle Nerve. 2005 Aug;32(2):140-63
pubmed: 15825186
FASEB J. 2011 May;25(5):1653-63
pubmed: 21282204
J Appl Physiol (1985). 2009 Jul;107(1):224-34
pubmed: 19390003
Nutrition. 2006 Jul-Aug;22(7-8):830-44
pubmed: 16815497
Int J Chron Obstruct Pulmon Dis. 2021 Jun 04;16:1661-1675
pubmed: 34113097
Chin J Physiol. 2020 May-Jun;63(3):101-112
pubmed: 32594063
Int J Mol Sci. 2019 May 13;20(9):
pubmed: 31085992
Cell. 2003 May 16;113(4):483-94
pubmed: 12757709
Int J Mol Sci. 2021 Apr 08;22(8):
pubmed: 33918092
Cell. 2011 Nov 11;147(4):728-41
pubmed: 22078875
Biosci Rep. 2019 Nov 29;39(11):
pubmed: 31702007
FASEB J. 2011 Jan;25(1):358-69
pubmed: 20889618
Front Physiol. 2020 Dec 03;11:580223
pubmed: 33343385
J Cachexia Sarcopenia Muscle. 2019 Dec;10(6):1210-1227
pubmed: 31507080
J Biol Chem. 2007 Jul 13;282(28):20059-63
pubmed: 17502367
Nutrients. 2019 Nov 10;11(11):
pubmed: 31717643
Nutr Cancer. 2011;63(5):749-62
pubmed: 21660860
Science. 2011 Jan 28;331(6016):456-61
pubmed: 21205641
Crit Care Med. 2017 Sep;45(9):e971-e979
pubmed: 28538438
Skelet Muscle. 2019 May 24;9(1):13
pubmed: 31126323
Arch Biochem Biophys. 2019 Mar 30;664:157-166
pubmed: 30771297
J Biol Chem. 2015 Apr 24;290(17):11177-87
pubmed: 25787076
Front Physiol. 2018 Mar 14;9:215
pubmed: 29593571
J Biol Chem. 2002 Dec 20;277(51):49831-40
pubmed: 12244043
Ann Transl Med. 2019 Sep;7(18):440
pubmed: 31700876
J Thorac Dis. 2018 May;10(Suppl 12):S1415-S1424
pubmed: 29928523
J Microbiol Biotechnol. 2020 Dec 28;30(12):1896-1904
pubmed: 32627754
J Cell Mol Med. 2021 Feb;25(3):1493-1506
pubmed: 33405354
Vitam Horm. 2009;80:613-33
pubmed: 19251052
Front Cell Neurosci. 2021 Jun 30;15:663384
pubmed: 34276308
Autophagy. 2009 Aug;5(6):795-804
pubmed: 19550147
Curr Opin Clin Nutr Metab Care. 2013 Jan;16(1):83-8
pubmed: 23196814
Exp Physiol. 2013 Jan;98(1):19-24
pubmed: 22848079
Front Endocrinol (Lausanne). 2016 Mar 29;7:24
pubmed: 27065945
J Cachexia Sarcopenia Muscle. 2022 Feb;13(1):713-727
pubmed: 34821076
Nutrients. 2018 Mar 30;10(4):
pubmed: 29601492
Physiol Rep. 2015 Aug;3(8):
pubmed: 26296771
Hum Mol Genet. 2008 Dec 15;17(24):3897-908
pubmed: 18782848
Phytomedicine. 2019 Feb;53:96-106
pubmed: 30668418
EMBO Rep. 2013 Dec;14(12):1062-72
pubmed: 24232182
Ann Am Thorac Soc. 2016 Mar;13(3):334-41
pubmed: 26700501
Cells. 2020 Jun 11;9(6):
pubmed: 32545383
Adv Exp Med Biol. 2018;1088:605-624
pubmed: 30390273
J Appl Physiol (1985). 2016 Mar 15;120(6):592-8
pubmed: 26769954
Am J Physiol Cell Physiol. 2007 May;292(5):C1660-71
pubmed: 17151142
Life Sci. 2017 Feb 1;170:56-63
pubmed: 27919820
Biomed Pharmacother. 2017 Jun;90:311-320
pubmed: 28364603
Ann N Y Acad Sci. 2012 Jul;1261:55-63
pubmed: 22823394
J Anim Sci. 2008 Apr;86(14 Suppl):E19-35
pubmed: 17709792
Br J Pharmacol. 2021 Aug;178(15):2998-3016
pubmed: 33788266
Acta Pharm Sin B. 2020 May;10(5):734-745
pubmed: 32528825
Am J Chin Med. 2020;48(3):631-650
pubmed: 32329640
Physiol Rev. 2010 Apr;90(2):495-511
pubmed: 20393192
Adv Exp Med Biol. 2018;1088:235-248
pubmed: 30390254
Immunity. 2012 Feb 24;36(2):239-50
pubmed: 22342841
Int J Mol Sci. 2020 Feb 25;21(5):
pubmed: 32106603
Biochem Pharmacol. 2022 Apr;198:114954
pubmed: 35167807
Biochim Biophys Acta Proteins Proteom. 2021 May;1869(5):140616
pubmed: 33545367
Nat Immunol. 2015 May;16(5):448-57
pubmed: 25898198
Am J Physiol Cell Physiol. 2011 Dec;301(6):C1316-24
pubmed: 21900687
Biochim Biophys Acta Gen Subj. 2018 Apr;1862(4):895-906
pubmed: 29288771
Springerplus. 2016 May 13;5:619
pubmed: 27330885
Cell. 2004 Apr 30;117(3):399-412
pubmed: 15109499
Cells. 2020 Aug 26;9(9):
pubmed: 32858949
Nat Rev Cancer. 2009 Aug;9(8):537-49
pubmed: 19629069
Nihon Yakurigaku Zasshi. 2020;155(4):241-247
pubmed: 32612037
J Microbiol Biotechnol. 2018 Apr 28;28(4):520-526
pubmed: 29724080
Zhonghua Yi Xue Za Zhi. 2018 Mar 13;98(10):749-754
pubmed: 29562399
Cells. 2021 Apr 26;10(5):
pubmed: 33925786
J Cachexia Sarcopenia Muscle. 2020 Feb;11(1):103-119
pubmed: 31441598
Am J Physiol Renal Physiol. 2017 Oct 1;313(4):F938-F950
pubmed: 28701312
Arch Pharm Res. 2020 Nov;43(11):1144-1161
pubmed: 33165832
Science. 2001 Nov 23;294(5547):1704-8
pubmed: 11679633
Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11025-30
pubmed: 12177420
J Sport Health Sci. 2019 Mar;8(2):189-195
pubmed: 30997266
Am J Physiol Endocrinol Metab. 2020 May 1;318(5):E625-E635
pubmed: 32101031
J Clin Invest. 2004 Jan;113(1):115-23
pubmed: 14702115
Biochimie. 2016 Mar;122:169-87
pubmed: 26363099
Int J Mol Sci. 2014 Jun 20;15(6):11126-41
pubmed: 24955790
Mol Med Rep. 2018 Mar;17(3):3674-3680
pubmed: 29257347
J Biol Chem. 2008 Aug 22;283(34):23224-34
pubmed: 18552402
Ann Transl Med. 2020 Dec;8(24):1681
pubmed: 33490193
J Am Soc Nephrol. 2006 Nov;17(11):3233-9
pubmed: 17005936
Curr Opin Clin Nutr Metab Care. 2004 May;7(3):265-9
pubmed: 15075917
Mol Biol Rep. 2018 Dec;45(6):1611-1619
pubmed: 30178217
Endocrinology. 2007 Jan;148(1):452-60
pubmed: 17038559
Ann Transl Med. 2019 Sep;7(18):456
pubmed: 31700892
Biochim Biophys Acta Mol Cell Res. 2018 Jan;1865(1):95-104
pubmed: 28765049
Inflammation. 2021 Aug;44(4):1223-1228
pubmed: 33907915
Int J Mol Sci. 2021 Aug 31;22(17):
pubmed: 34502376
Antioxidants (Basel). 2022 Feb 01;11(2):
pubmed: 35204186
Nutr Metab (Lond). 2021 Nov 1;18(1):98
pubmed: 34724970
J Cell Biol. 2009 Dec 14;187(6):859-74
pubmed: 20008564
J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1413-1428
pubmed: 33053604
Elife. 2019 Dec 03;8:
pubmed: 31793435
Front Physiol. 2019 Oct 11;10:1298
pubmed: 31681010
Oxid Med Cell Longev. 2018 Nov 8;2018:8927104
pubmed: 30533176
Mar Drugs. 2018 Dec 08;16(12):
pubmed: 30544821
Phytomedicine. 2022 Jan;95:153858
pubmed: 34861585
Front Physiol. 2019 Jun 25;10:665
pubmed: 31293430
Front Physiol. 2020 Nov 19;11:597675
pubmed: 33329046
Nat Med. 2010 Nov;16(11):1313-20
pubmed: 21037586
Front Endocrinol (Lausanne). 2021 Sep 28;12:724911
pubmed: 34650518
J Exp Med. 2011 Nov 21;208(12):2449-63
pubmed: 22084407
FEBS J. 2013 Sep;280(17):4131-48
pubmed: 23663276
Front Endocrinol (Lausanne). 2016 Jun 29;7:81
pubmed: 27445984
Biochem Biophys Res Commun. 2017 May 20;487(1):83-89
pubmed: 28392400
Front Immunol. 2021 Sep 06;12:730070
pubmed: 34552592
Shock. 2022 Mar 1;57(3):397-407
pubmed: 34559744
Cells. 2020 Mar 13;9(3):
pubmed: 32183037
Int J Mol Sci. 2018 Nov 27;19(12):
pubmed: 30486451
J Ethnopharmacol. 2020 Oct 5;260:113066
pubmed: 32505837
Front Physiol. 2020 Aug 12;11:988
pubmed: 32903465
Nat Cell Biol. 2008 Oct;10(10):1199-207
pubmed: 18758450
Int J Sports Med. 2020 Dec;41(14):994-1008
pubmed: 32679598
Life Sci. 2001 Aug 10;69(12):1345-61
pubmed: 11531159
PLoS One. 2012;7(6):e39657
pubmed: 22761857
Diabetes. 2009 May;58(5):1086-95
pubmed: 19188427
BMC Nephrol. 2018 Feb 27;19(1):45
pubmed: 29486729