Balancing the Virulence and Antimicrobial Resistance in VISA DAP-R CA-MRSA Superbug.
CA-MRSA
VISA
antimicrobial resistance
omics
virulence
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
27 Aug 2022
27 Aug 2022
Historique:
received:
29
07
2022
revised:
22
08
2022
accepted:
24
08
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
Methicillin-resistant Whole-genome sequencing, RNA-Seq and bioinformatics were carried out. Our CA-MRSA clustered in the USA400 lineage showing additional antimicrobial resistance (AMR) versus DAP and glycopeptides. Resistomics revealed adaptations related to glycopeptide, daptomycin and rifampin resistance ( Our data show that VISA DAP-R CA-MRSA shifts the potential hypervirulent behavior of CA-MRSA towards the acquisition and maintenance of extensive AMR, by a decrease in virulence and biological costs mediated by a "compensatory modulatory mutation" silencing the Agr quorum-sensing cascade.
Sections du résumé
BACKGROUND
BACKGROUND
Methicillin-resistant
METHODS
METHODS
Whole-genome sequencing, RNA-Seq and bioinformatics were carried out.
RESULTS
RESULTS
Our CA-MRSA clustered in the USA400 lineage showing additional antimicrobial resistance (AMR) versus DAP and glycopeptides. Resistomics revealed adaptations related to glycopeptide, daptomycin and rifampin resistance (
CONCLUSION
CONCLUSIONS
Our data show that VISA DAP-R CA-MRSA shifts the potential hypervirulent behavior of CA-MRSA towards the acquisition and maintenance of extensive AMR, by a decrease in virulence and biological costs mediated by a "compensatory modulatory mutation" silencing the Agr quorum-sensing cascade.
Identifiants
pubmed: 36139939
pii: antibiotics11091159
doi: 10.3390/antibiotics11091159
pmc: PMC9495084
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : University of Catania
ID : Starting Grant PIACERI n. 253556 del 16 marzo 2021
Organisme : Ministry of Education, Universities and Research
ID : PRIN2017SFBFER
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