Epidemiology, Mechanisms of Resistance and Treatment Algorithm for Infections Due to Carbapenem-Resistant Gram-Negative Bacteria: An Expert Panel Opinion.
Acinetobacter baumannii
Enterobacterales
Pseudomonas aeruginosa
Stenotrophomonas maltophilia
antimicrobial resistance
carbapenem-resistant organisms
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
17 Sep 2022
17 Sep 2022
Historique:
received:
05
08
2022
revised:
05
09
2022
accepted:
13
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
Antimicrobial resistance represents a serious threat for global health, causing an unacceptable burden in terms of morbidity, mortality and healthcare costs. In particular, in 2017, carbapenem-resistant organisms were listed by the WHO among the group of pathogens for which novel treatment strategies are urgently needed. Fortunately, several drugs and combinations have been introduced in recent years to treat multi-drug-resistant (MDR) bacteria. However, a correct use of these molecules is needed to preserve their efficacy. In the present paper, we will provide an overview on the epidemiology and mechanisms of resistance of the most common MDR Gram-negative bacteria, proposing a treatment algorithm for the management of infections due to carbapenem-resistant bacteria based on the most recent clinical evidence.
Identifiants
pubmed: 36140042
pii: antibiotics11091263
doi: 10.3390/antibiotics11091263
pmc: PMC9495208
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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