Epigenetic Suppression of the IL-7 Pathway in Progressive Glioblastoma.
CpG methylation
epigenomics
glioblastoma
immune evasion
interleukin 7 pathway
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
02 Sep 2022
02 Sep 2022
Historique:
received:
13
08
2022
revised:
26
08
2022
accepted:
30
08
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
Immune evasion in glioblastoma (GBM) shields cancer cells from cytotoxic immune response. We investigated CpG methylation in promoters, genes, and pathways in 22 pairs of formalin-fixed paraffin-embedded sequential (FFPE) GBM using restricted resolution bisulfite sequencing (RRBS) and bioinformatic analyses. Gene ontology revealed hypermethylation in elements of the innate and adaptive immune system when recurrent GBM samples (GBM This study revealed the progressive suppression of the IL-7 receptor-mediated pathway as a means of immune evasion by GBM and thereby highlighted it as a new treatment target.
Sections du résumé
BACKGROUND
BACKGROUND
Immune evasion in glioblastoma (GBM) shields cancer cells from cytotoxic immune response.
METHODS
METHODS
We investigated CpG methylation in promoters, genes, and pathways in 22 pairs of formalin-fixed paraffin-embedded sequential (FFPE) GBM using restricted resolution bisulfite sequencing (RRBS) and bioinformatic analyses.
RESULTS
RESULTS
Gene ontology revealed hypermethylation in elements of the innate and adaptive immune system when recurrent GBM samples (GBM
CONCLUSIONS
CONCLUSIONS
This study revealed the progressive suppression of the IL-7 receptor-mediated pathway as a means of immune evasion by GBM and thereby highlighted it as a new treatment target.
Identifiants
pubmed: 36140275
pii: biomedicines10092174
doi: 10.3390/biomedicines10092174
pmc: PMC9496096
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Elixir Converge
ID : Nr. 871075
Organisme : Natikonal Research, Development and Innovation Fund, Hungary
ID : TKP2020-4.1.1
Organisme : Ginop
ID : GINOP-2.3.4-15-2020-00010
Organisme : Ginop
ID : GINOP-2.3.1-20-2020- 00001
Organisme : Erasmus+
ID : 2019-0-HU01-KA203-061251
Organisme : H2020-MSCA-COFUND Marie Skłodowska-Curie
ID : Nr. 754432
Références
Pathol Res Pract. 2021 Jun;222:153429
pubmed: 33857857
Cells. 2021 Aug 09;10(8):
pubmed: 34440802
Front Immunol. 2020 Oct 15;11:582106
pubmed: 33178210
Immunol Rev. 2006 Jun;211:81-92
pubmed: 16824119
J Immunother. 2006 May-Jun;29(3):313-9
pubmed: 16699374
Cell Rep. 2021 Jul 13;36(2):109349
pubmed: 34260907
BMC Cancer. 2022 Jun 27;22(1):707
pubmed: 35761256
Clin Cancer Res. 2014 Jan 1;20(1):131-9
pubmed: 24097874
Nature. 2012 Feb 15;483(7390):479-83
pubmed: 22343889
Int J Mol Sci. 2020 Apr 16;21(8):
pubmed: 32316096
Acta Neuropathol. 2016 Jun;131(6):803-20
pubmed: 27157931
J Immunol. 2020 Feb 15;204(4):844-857
pubmed: 31924648
J Cancer Res Clin Oncol. 2020 Nov;146(11):2885-2896
pubmed: 32779022
Cancer Med. 2022 Aug 3;:
pubmed: 35920297
Asia Pac J Clin Oncol. 2022 Aug;18(4):335-343
pubmed: 34811893
Cancers (Basel). 2022 Jul 13;14(14):
pubmed: 35884454
Front Immunol. 2020 Jun 04;11:1105
pubmed: 32582189
Cancer Cell. 2010 Jan 19;17(1):98-110
pubmed: 20129251
Cancer Cell. 2010 May 18;17(5):510-22
pubmed: 20399149
Nat Biotechnol. 2020 Apr;38(4):448-459
pubmed: 32015548
Adv Biol Regul. 2021 May;80:100788
pubmed: 33578108
Nat Med. 2018 Oct;24(10):1611-1624
pubmed: 30150718
Science. 2022 Jul 29;377(6605):502-511
pubmed: 35901163
Neuro Oncol. 2021 Aug 2;23(8):1231-1251
pubmed: 34185076
Nature. 2008 Oct 23;455(7216):1061-8
pubmed: 18772890
Cancer Discov. 2017 Nov;7(11):1238-1247
pubmed: 28830878
Cancer Immunol Immunother. 2021 Sep;70(9):2453-2465
pubmed: 33543339
Semin Cancer Biol. 2022 Aug;83:503-522
pubmed: 33309850
Cell. 2021 Apr 29;184(9):2454-2470.e26
pubmed: 33857425
Neurosci Lett. 1993 Oct 1;160(2):131-4
pubmed: 8247342
Cells. 2021 Mar 04;10(3):
pubmed: 33806345
Clin Cancer Res. 2011 Aug 15;17(16):5473-80
pubmed: 21737504
Nat Rev Immunol. 2007 Feb;7(2):144-54
pubmed: 17259970
Science. 1993 Dec 17;262(5141):1877-80
pubmed: 8266077