Myosins and MyomiR Network in Patients with Obstructive Hypertrophic Cardiomyopathy.
MyomiR (myosin-encoded miRs)
Polypyrimidine Tract Binding Protein 3 (PTBP3)
SRY-Box Transcription Factor 6 (SOX6)
cardiomyocytes
hypertrophic cardiomyopathy (HCM)
miR-499
microRNA (miRs)
myosin heavy chain (isoform: MyHC, gene: MYH)
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
03 Sep 2022
03 Sep 2022
Historique:
received:
20
06
2022
revised:
30
08
2022
accepted:
01
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy. The molecular mechanisms determining HCM phenotypes are incompletely understood. Myocardial biopsies were obtained from a group of patients with obstructive HCM (n = 23) selected for surgical myectomy and from 9 unused donor hearts (controls). A subset of tissue-abundant myectomy samples from HCM (n = 10) and controls (n = 6) was submitted to laser-capture microdissection to isolate cardiomyocytes. We investigated the relationship among clinical phenotype, cardiac myosin proteins (MyHC6, MyHC7, and MyHC7b) measured by optimized label-free mass spectrometry, the relative genes (
Identifiants
pubmed: 36140281
pii: biomedicines10092180
doi: 10.3390/biomedicines10092180
pmc: PMC9496008
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministero della Salute
ID : NET-2011-02347173
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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